Cited by 442Pain Management and Placebo EffectPain Mechanisms and TreatmentsPain Management and Opioid Use

The DOI matches its Crossref record; 24 of the 25 references it cites were found in a registry or an index.

Response expectancies in placebo analgesia and their clinical relevance

Pollo, Antonella, Amanzio, Martina, Arslanian, Anna, Casadio, Caterina, Maggi, Giuliano, Benedetti, Fabrizio·2001·Pain

Open this paper in CoChat — free account

Abstract

Response expectancies have been proposed as the major determinant of placebo effects. Here we report that different expectations produce different analgesic effects which in turn can be harnessed in clinical practice. Thoracotomized patients were treated with buprenorphine on request for 3 consecutive days, together with a basal intravenous infusion of saline solution. However, the symbolic meaning of this basal infusion was changed in three different groups of patients. The first group was told nothing about any analgesic effect (natural history). The second group was told that the basal infusion was either a powerful painkiller or a placebo (classic double-blind administration). The third group was told that the basal infusion was a potent painkiller (deceptive administration). Therefore, whereas the analgesic treatment was exactly the same in the three groups, the verbal instructions about the basal infusion differed. The placebo effect of the saline basal infusion was measured by recording the doses of buprenorphine requested over the three-days treatment. We found that the double-blind group showed a reduction of buprenorphine requests compared to the natural history group. However, this reduction was even larger in the deceptive administration group. Overall, after 3 days of placebo infusion, the first group received 11.55 mg of buprenorphine, the second group 9.15 mg, and the third group 7.65 mg. Despite these dose differences, analgesia was the same in the three groups. These results indicate that different verbal instructions about certain and uncertain expectations of analgesia produce different placebo analgesic effects, which in turn trigger a dramatic change of behaviour leading to a significant reduction of opioid intake.

Integrity signals

Registry

Crossref · 10.1016/s0304-3959(01)00296-2

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Pavlovian conditioning: it's not what you think it is
Rescorla, R. A. (1988) · American Psychologist · doi:10.1037/0003-066x.43.3.151 · Cited by 1,542
Response expectancy as a determinant of experience and behavior.
Kirsch, I. (1985) · American Psychologist · doi:10.1037/0003-066x.40.11.1189 · Cited by 1,014
Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems
Amanzio, M., & Benedetti, F. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00484.1999 · Cited by 899
Self-citation
An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm
Price, D. D., Milling, L. S., Kirsch, I., Duff, A., Montgomery, G. H., & Nicholls, S. S. (1999) · Pain · doi:10.1016/s0304-3959(99)00081-0 · Cited by 569
Classical conditioning and the placebo effect
Montgomery, G. H., & Kirsch, I. (1997) · Pain · doi:10.1016/s0304-3959(97)00016-x · Cited by 468
The role of conditioning and verbal expectancy in the placebo response
Voudouris, N. J., Peck, C. L., & Coleman, G. (1990) · Pain · doi:10.1016/0304-3959(90)90057-k · Cited by 369
Somatotopic Activation of Opioid Systems by Target-Directed Expectations of Analgesia
Benedetti, F., Arduino, C., & Amanzio, M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-09-03639.1999 · Cited by 350
Self-citation
Changing expectations: a key to effective psychotherapy
(1990) · Choice Reviews Online · doi:10.5860/choice.28-2424 · Cited by 342
CLINICIANS' EXPECTATIONS INFLUENCE PLACEBO ANALGESIA
Gracely, R. H., Dubner, R. A., Deeter, W. R., & Wolskee, P. J. (1985) · The Lancet · doi:10.1016/s0140-6736(85)90984-5 · Cited by 311
The Placebo Effect: An Interdisciplinary Exploration
Harrington, A. (1999) · DigitalGeorgetown (Georgetown University Library) · Cited by 303

Show all 25 references

Sorted by citations

Items 101–200 of 441

Placebo-Induced Improvements: How Therapeutic Rituals Affect the Patient's Brain
Benedetti, F. (2012) · Journal of Acupuncture and Meridian Studies · doi:10.1016/j.jams.2012.03.001 · Cited by 61
Self-citation
Placebo effects in osteoarthritis: implications for treatment and drug development
Neogi, T., & Colloca, L. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-01021-4 · Cited by 61
Patients' direct experiences as central elements of placebo analgesia
Vase, L., Nørskov, K. N., Petersen, G. L., & Price, D. D. (2011) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0402 · Cited by 59
Nocebo vs. Placebo: The Challenges of Trial Design in Analgesia Research
Vase, L., Amanzio, M., & Price, D. D. (2015) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.31 · Cited by 54
Self-citation
Hypnotic susceptibility modulates brain activity related to experimental placebo analgesia
Huber, A., Lui, F., & Porro, C. A. (2013) · Pain · doi:10.1016/j.pain.2013.03.031 · Cited by 53
Functional neurological disorder and placebo and nocebo effects: shared mechanisms
Fiorio, M., Braga, M., Marotta, A., Villa‐Sánchez, B., Edwards, M. J., Tinazzi, M., & Barbiani, D. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00711-z · Cited by 56
Seeing What We Want to See: Confirmation Bias in Animal Behavior Research
Marsh, D. M., & Hanlon, T. J. (2007) · Ethology · doi:10.1111/j.1439-0310.2007.01406.x · Cited by 53
Mechanisms and Clinical Implications of the Placebo Effect: Is There a Potential for the Elderly? A Mini-Review
Bingel, U., Colloca, L., & Vase, L. (2010) · Gerontology · doi:10.1159/000322090 · Cited by 53
Power of Words: Influence of Preexercise Information on Hypoalgesia after Exercise—Randomized Controlled Trial
Vægter, H. B., Thinggaard, P., MADSEN, C. H., Hasenbring, M. I., & Thorlund, J. B. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002396 · Cited by 53
The placebo response: neurobiological and clinical issues of neurological relevance
Pollo, A., & Benedetti, F. (2009) · Progress in brain research · doi:10.1016/s0079-6123(09)17520-9 · Cited by 52
Self-citation
Placebo and other psychological interactions in headache treatment
Autret, A., Valade, D., & Debiais, S. (2012) · The Journal of Headache and Pain · doi:10.1007/s10194-012-0422-0 · Cited by 53
Perceived treatment, feedback, and placebo effects in double-blind RCTs: an experimental analysis
Colagiuri, B., & Boakes, R. A. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1743-9 · Cited by 50
The Measurement of Pain: Objectifying the Subjective
Correll, D. (2007) · Elsevier eBooks · doi:10.1016/b978-0-7216-0334-6.50022-4 · Cited by 52
Acupuncture in the treatment of fatigue in Parkinson’s disease: a pilot, randomized, controlled, study
Kong, K. H., Ng, H. L., Li, W., Ng, D. W., Tan, S. I., Tay, K. Y., Au, W. L., & Tan, L. C. S. (2018) · Brain and Behavior · doi:10.1002/brb3.897 · Cited by 48
Expectations Modulate Heterotopic Noxious Counter-Stimulation Analgesia
Cormier, S., Piché, M., & Rainville, P. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.10.006 · Cited by 47
Placebo and Nocebo Effects in Randomized Controlled Trials: The Implications for Research and Practice
Sanderson, C. R., Hardy, J. R., Spruyt, O., & Currow, D. C. (2013) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2012.12.005 · Cited by 50
Preventing motor training through nocebo suggestions
Pollo, A., Carlino, E., Vase, L., & Benedetti, F. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2333-9 · Cited by 49
Self-citation
The use of pure and impure placebo interventions in primary care - a qualitative approach
Fent, R., Rosemann, T. J., Fässler, M., Senn, O., & Huber, C. A. (2011) · BMC Family Practice · doi:10.1186/1471-2296-12-11 · Cited by 48
Pain reduction by infrared light-emitting diode irradiation: a pilot study on experimentally induced delayed-onset muscle soreness in humans
Vinck, E. M., Cagnie, B. J., Coorevits, P. L., Vanderstraeten, G., & Cambier, D. C. (2006) · Lasers in Medical Science · doi:10.1007/s10103-005-0366-6 · Cited by 46
Cognitive changes as a result of a single exposure to placebo
Morton, D. L., Brown, C. A., Watson, A., El‐Deredy, W., & Jones, A. K. P. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.03.016 · Cited by 46
An Examination of the Observed Placebo Effect Associated with the Treatment of Low Back Pain – A Systematic Review
Puhl, A. A., Reinhart, C. J., Rok, E. R., & Injeyan, H. S. (2011) · Pain Research and Management · doi:10.1155/2011/625315 · Cited by 44
Treatment history and placebo responses to experimental and clinical pain in chronic pain patients
Müller, M., Kamping, S., Benrath, J., Skowronek, H., Schmitz, J., Klinger, R., & Flor, H. (2016) · European Journal of Pain · doi:10.1002/ejp.877 · Cited by 42
Relieving phantom limb pain with multimodal sensory-motor training
Nunzio, A. M. D., Schweisfurth, M. A., Ge, N., Falla, D., Hahne, J. M., Gödecke, K., Petzke, F. W., Siebertz, M. W., Dechent, P., Weiß, T., et al. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aae271 · Cited by 47
APS position statement on the use of placebos in pain management
Sullivan, M. D., Terman, G. W., Peck, B., Correll, D., Rich, B. A., Clark, W. C., Latta, K. S., Lebovits, A., & Gebhart, G. F. (2005) · Journal of Pain · doi:10.1016/j.jpain.2005.01.347 · Cited by 42
Placebo Effects and Informed Consent
Alfano, M. (2015) · The American Journal of Bioethics · doi:10.1080/15265161.2015.1074302 · Cited by 42
Investigating dose-dependent effects of placebo analgesia: A psychophysiological approach
Nakamura, Y., Donaldson, G. W., Kuhn, R., Bradshaw, D. H., Jacobson, R. C., & Chapman, R. C. (2011) · Pain · doi:10.1016/j.pain.2011.10.024 · Cited by 42
Acupuncture: What Underlies Needle Administration?
Liu, T. (2007) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nen002 · Cited by 41
Identifying Placebo Effects with Data from Clinical Trials
Malani, A. (2006) · Journal of Political Economy · doi:10.1086/500279 · Cited by 40
A preliminary investigation into the effects of active interferential current therapy and placebo on pressure pain sensitivity: a random crossover placebo controlled study
Fuentes C, J., Armijo-Olivo, S., Magee, D. J., & Gross, D. P. (2011) · Physiotherapy · doi:10.1016/j.physio.2011.01.001 · Cited by 37
The Influence of Expectancy Level and Personal Characteristics on Placebo Effects: Psychological Underpinnings
Zhou, L., Wei, H., Zhang, H., Li, X., Bo, C., Wan, L., Lu, X., & Hu, L. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00020 · Cited by 40
Understanding placebo and nocebo effects in the context of sport: A psychological perspective
Raglin, J. S., Szabó, A., Lindheimer, J. B., & Beedie, C. (2020) · European Journal of Sport Science · doi:10.1080/17461391.2020.1727021 · Cited by 39
A Comparison of Deceptive and Non-Deceptive Placebo Analgesia: Efficacy and Ethical Consequences
Mundt, J. M., Roditi, D., & Robinson, M. E. (2016) · Annals of Behavioral Medicine · doi:10.1007/s12160-016-9854-0 · Cited by 34
Systematic review with meta‐analysis: endoscopic and histologic placebo rates in induction and maintenance trials of ulcerative colitis
Ma, C., Guizzetti, L., Panaccione, R., Fedorak, R. N., Pai, R. K., Parker, C. E., Nguyen, T. M., Khanna, R., Casteele, N. V., D’Haens, G., et al. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14672 · Cited by 36
Placebo Adverse Events in Headache Trials: Headache as an Adverse Event of Placebo
Reuter, U., del Río, M. S., Carpay, J. A. H., Boes, C. J., Silberstein, S., & Program, F. T. G. H. M. (2003) · Cephalalgia · doi:10.1046/j.1468-2982.2003.00530.x · Cited by 35
What do you expect from this treatment? Changing our mind about clinical trials
Benedetti, F. (2007) · Pain · doi:10.1016/j.pain.2007.01.005 · Cited by 36
Self-citation
Medicine's inconvenient truth: the placebo and nocebo effect
Arnold, M. H., Finniss, D. G., & Kerridge, I. (2014) · Internal Medicine Journal · doi:10.1111/imj.12380 · Cited by 36
Brain structural properties predict psychologically mediated hypoalgesia in an 8-week sham acupuncture treatment for migraine
Liu, J., Mu, J., Liu, Q., Dun, W., Zhang, M., & Tian, J. (2017) · Human Brain Mapping · doi:10.1002/hbm.23667 · Cited by 36
Placebo Effects: Historical and Modern Evaluation
Finniss, D. G. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.010 · Cited by 37
Cognitive Factors Mediate Placebo Responses in Patients with House Dust Mite Allergy
Vits, S., Cesko, E., Benson, S., Rueckert, A., Hillen, U., Schadendorf, D., & Schedlowski, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079576 · Cited by 37
Pain management in the opioid-dependent patient
Streltzer, J. (2001) · Current Psychiatry Reports · doi:10.1007/s11920-001-0043-9 · Cited by 35
Integration of white matter network is associated with interindividual differences in psychologically mediated placebo response in migraine patients
Liu, J., Ma, S., Mu, J., Chen, T., Xu, Q., Dun, W., Tian, J., & Zhang, M. (2017) · Human Brain Mapping · doi:10.1002/hbm.23729 · Cited by 35
Psychobiology of the placebo response
Klosterhalfen, S., & Enck, P. (2006) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.01.015 · Cited by 33
Perceived treatment group affects behavioral and neural responses to visceral pain in a deceptive placebo study
Kotsis, V., Benson, S., Bingel, U., Forsting, M., Schedlowski, M., Gizewski, E. R., & Elsenbruch, S. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01968.x · Cited by 33
Do cultures influence placebo response?
Bhugra, D., & Ventriglio, A. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12422 · Cited by 33
Understanding and managing the interaction between sleep and pain: an update for the dentist.
Brousseau, M., Manzini, C., Thie, N. M. R., & Lavigne, G. J. (2003) · PubMed · Cited by 33
Placebo analgesia: cognitive influences on therapeutic outcome
Watson, A., Power, A., Brown, C. A., El‐Deredy, W., & Jones, A. K. P. (2012) · Arthritis Research & Therapy · doi:10.1186/ar3783 · Cited by 36
The sustained influence of prior experience induced by social observation on placebo and nocebo responses
Zhang, H., Zhou, L., Wei, H., Lu, X., & Hu, L. (2017) · Journal of Pain Research · doi:10.2147/jpr.s147970 · Cited by 30
Alleviation of migraine symptoms by application of repetitive peripheral magnetic stimulation to myofascial trigger points of neck and shoulder muscles – A randomized trial
Renner, T., Sollmann, N., Heinen, F., Albers, L. E., Trepte-Freisleder, F., Klose, B., König, H., Krieg, S. M., Bonfert, M. V., & Landgraf, M. N. (2020) · Scientific Reports · doi:10.1038/s41598-020-62701-9 · Cited by 32
Historical Controls in Randomized Clinical Trials: Opportunities and Challenges
Hall, K. T., Vase, L., Tobias, D. K., Dashti, H., Vollert, J., Kaptchuk, T. J., & Cook, N. R. (2020) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1970 · Cited by 32
Subjective and objective effects of coffee consumption — caffeine or expectations?
Dömötör, Z., Szemerszky, R., & Köteles, F. G. (2014) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.101.2014.012 · Cited by 31
Placebo expectations and the detection of somatic information
Geers, A. L., Wellman, J. A., Fowler, S. L., Rasinski, H. M., & Helfer, S. G. (2010) · Journal of Behavioral Medicine · doi:10.1007/s10865-010-9301-9 · Cited by 32
Can a brief psychological expectancy intervention improve postoperative pain? A randomized, controlled trial in patients with breast cancer
Benson, S., Hagen, S., Hoffmann, O., Pasler, A., Bingel, U., Schedlowski, M., Peters, J., Elsenbruch, S., & Frey, U. H. (2019) · Pain · doi:10.1097/j.pain.0000000000001546 · Cited by 32
New insights into placebo analgesia
Benedetti, F., Rainero, I., & Pollo, A. (2003) · Current Opinion in Anaesthesiology · doi:10.1097/00001503-200310000-00012 · Cited by 30
Self-citation
The influence of clinical equipoise and patient preferences on outcomes of conservative manual interventions for spinal pain: an experimental study
Bishop, M. D., Bialosky, J. E., Penza, C. W., Beneciuk, J. M., & Alappattu, M. J. (2017) · Journal of Pain Research · doi:10.2147/jpr.s130931 · Cited by 31
The Placebo Phenomenon: A Narrow Focus on Psychological Models
Peiris, N., Blasini, M., Wright, T. B., & Colloca, L. (2018) · Perspectives in biology and medicine · doi:10.1353/pbm.2018.0051 · Cited by 29
Placebo can enhance creativity
Rozenkrantz, L., Mayo, A., Ilan, T., Hart, Y., Noy, L., & Alon, U. S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182466 · Cited by 31
Placebo use in pain management: The role of medical context, treatment efficacy, and deception in determining placebo acceptability
Kisaalita, N. R., Staud, R. M., Hurley, R. W., & Robinson, M. (2014) · Pain · doi:10.1016/j.pain.2014.09.029 · Cited by 31
Effects of an Injected Placebo on Endurance Running Performance
Ross, R., Gray, C. M., & Gill, J. M. R. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000584 · Cited by 32
The placebo and nocebo effects on peak minute power during incremental arm crank ergometry
Bottoms, L. M., Buscombe, R. M., & Nicholettos, A. (2013) · European Journal of Sport Science · doi:10.1080/17461391.2013.822564 · Cited by 29
The Effect of Temporal Information on Placebo Analgesia and Nocebo Hyperalgesia
Camerone, E. M., Piedimonte, A., Testa, M., Wiech, K., Vase, L., Zamfira, D. A., Benedetti, F., & Carlino, E. (2020) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000882 · Cited by 29
Self-citation
Opioid analgesia alters corticospinal coupling along the descending pain system in healthy participants
Tinnermann, A., Sprenger, C., & Büchel, C. (2022) · eLife · doi:10.7554/elife.74293 · Cited by 31
Treatment Choice and Placebo Expectation Effects
Geers, A. L., & Rose, J. P. (2011) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2011.00385.x · Cited by 28
"Anxiebo", placebo, and postoperative pain
Svedman, P., Ingvar, M., & Gordh, T. (2005) · BMC Anesthesiology · doi:10.1186/1471-2253-5-9 · Cited by 27
The Effects of Manipulating Verbal Suggestions on Physical Performance
Carlino, E., Benedetti, F., & Pollo, A. (2014) · Zeitschrift für Psychologie · doi:10.1027/2151-2604/a000178 · Cited by 28
Self-citation
Effects of Electroacupuncture on Stress-Related Symptoms in Medical Students: A Randomised Placebo-Controlled Study
Dias, M., Vellarde, G., Olej, B., Salgado, A. E. T., & Rezende, I. D. B. (2014) · Acupuncture in Medicine · doi:10.1136/acupmed-2013-010408 · Cited by 26
Effect of Expectations on Treatment Outcome for Lumbar Intervertebral Disc Herniation
Lurie, J. D., Henderson, E. R., McDonough, C. M., Berven, S., Scherer, E. A., Tosteson, T. D., Tosteson, A. N. A., Hu, S. S., & Weinstein, J. N. (2015) · Spine · doi:10.1097/brs.0000000000001333 · Cited by 28
Open-label placebo response – Does optimism matter? A secondary-analysis of a randomized controlled trial
Locher, C., Nascimento, A. F., Kossowsky, J., Meyer, A. H., & Gaab, J. (2018) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.11.009 · Cited by 30
Nocebo context modulates long-term habituation to heat pain and influences functional connectivity of the operculum
Ellerbrock, I., Wiehler, A., Arndt, M., & May, A. (2015) · Pain · doi:10.1097/j.pain.0000000000000297 · Cited by 30
All in the mind? Pain, placebo effect, and ergogenic effect of caffeine in sports performance
Beedie, C. (2010) · Open Access Journal of Sports Medicine · doi:10.2147/oajsm.s6932 · Cited by 27
Implicit versus explicit associative learning and experimentally induced placebo hypoalgesia
Martin-Pichora, Mankovsky-Arnold, T., & Katz, J. D. (2011) · Journal of Pain Research · doi:10.2147/jpr.s15966 · Cited by 24
Placebo and Active Treatment Additivity in Placebo Analgesia: Research to Date and Future Directions
Coleshill, M. J., Sharpe, L., Colloca, L., Zachariae, R. H., & Colagiuri, B. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.021 · Cited by 27
Current experience with 5-HT3 receptor antagonists in fibromyalgia
Späth, M. (2002) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(01)00014-x · Cited by 25
Expectancy Reduces Symptoms but not Functional Impairment Following Exercise-induced Musculoskeletal Injury
Hedderson, W. C., Dover, G. C., George, S. Z., Crow, J. A., & Borsa, P. A. (2017) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000484 · Cited by 25
What It Takes to Defend Deceptive Placebo Use
Barnhill, A. (2011) · Kennedy Institute of Ethics journal · doi:10.1353/ken.2011.0015 · Cited by 24
Choose Your Words Wisely: The Impact of Message Framing on Patients' Responses to Treatment Advice
Glare, P. A., Fridman, I., & Ashton-James, C. E. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.020 · Cited by 24
Selecting new drugs for pain control
Jeske, A. H. (2002) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2002.0328 · Cited by 24
Placebo Responses to Original vs Generic ASA Brands During Exposure to Noxious Heat: A Pilot fMRI Study of Neurofunctional Correlates
Fehse, K., Maikowski, L. F., Simmank, F., Gutyrchik, E., & Meißner, K. (2015) · Pain Medicine · doi:10.1111/pme.12783 · Cited by 25
Catastrophizing and treatment outcome: differential impact on response to placebo and active treatment outcome
Sullivan, M. J. L., Lynch, M. E., Clark, A. J., Mankovsky-Arnold, T., & Sawynok, J. (2008) · Contemporary Hypnosis · doi:10.1002/ch.365 · Cited by 24
Route of placebo administration: Robust placebo effects in laboratory and clinical settings
Liu, T. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.018 · Cited by 25
Aerosol furosemide for dyspnea: Controlled delivery does not improve effectiveness
Morélot‐Panzini, C., O’Donnell, C. R., Lansing, R., Schwartzstein, R. M., & Banzett, R. B. (2017) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2017.10.002 · Cited by 24
Conditioning, expectation, and desire for relief in placebo analgesia
Price, D. D., Chung, S., & Robinson, M. E. (2005) · Seminars in Pain Medicine · doi:10.1016/j.spmd.2005.02.007 · Cited by 23
Pragmatic trials: how to adjust for the ‘Hawthorne effect’?
Konstantinou, G. Ν. (2011) · Thorax · doi:10.1136/thoraxjnl-2011-200657 · Cited by 23
Deceptive but not open label placebos attenuate motion-induced nausea
Barnes, K., Yu, A., Josupeit, J., & Colagiuri, B. (2019) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2019.109808 · Cited by 22
Somatic Symptom Perception From a Predictive Processing Perspective: An Empirical Test Using the Thermal Grill Illusion
Bräscher, A., Sütterlin, S., Scheuren, R., den Bergh, O. V., & Witthöft, M. (2020) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000824 · Cited by 26
Mechanismen der endogenen Schmerzmodulation am Beispiel der Placeboanalgesie
Bingel, U. (2010) · Der Schmerz · doi:10.1007/s00482-010-0901-7 · Cited by 23
The impact of psychological factors on placebo responses in a randomized controlled trial comparing sham device to dummy pill
Bertisch, S. M., Legedza, A., Phillips, R. S., Davis, R. B., Stason, W. B., Goldman, R. H., & Kaptchuk, T. J. (2009) · Journal of Evaluation in Clinical Practice · doi:10.1111/j.1365-2753.2008.00942.x · Cited by 22
Hypnotizability and Placebo Analgesia in Waking and Hypnosis as Modulators of Auditory Startle Responses in Healthy Women: An ERP Study
Pascalis, V. D., & Scacchia, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159135 · Cited by 22
Dissection of the Factors Driving the Placebo Effect in Hypnotic Treatment of Depressed Insomniacs
Mccall, W., D'Agostino, R., Rosenquist, P., Kimball, J., Boggs, N., Lasater, B., & Blocker, J. N. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2011.03.008 · Cited by 25
Efficacité thérapeutique de “l’effet médecin” en soins primaires
Moreau, A., Boussageon, R., Girier, P., & Figon, S. (2006) · La Presse Médicale · doi:10.1016/s0755-4982(06)74729-7 · Cited by 25
Focused analgesia and generalized relaxation produce differential hypnotic analgesia in response to ascending stimulus intensity
Sharav, Y., & Tal, M. (2004) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2003.10.001 · Cited by 22
The Role of Patients’ Response Expectancies in Side Effect Development and Control
Roscoe, J. A., Jean‐Pierre, P., Shelke, A. R., Kaufman, M. E., Bole, C. W., & Morrow, G. R. (2006) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2005.12.001 · Cited by 23
Treatment expectations and clinical outcomes following repetitive transcranial magnetic stimulation for treatment-resistant depression
Mollica, A., Ng, E., Burke, M. J., Nestor, S. M., Lee, H. H., Rabin, J. S., Hamani, C., Lipsman, N., & Giacobbe, P. (2024) · Brain stimulation · doi:10.1016/j.brs.2024.06.006 · Cited by 24
Choice and the Placebo Effect: A Meta-analysis
Tang, B., Barnes, K., Geers, A. L., Livesey, E. J., & Colagiuri, B. (2022) · Annals of Behavioral Medicine · doi:10.1093/abm/kaab111 · Cited by 21
Botulinum Toxin for the Treatment of Chronic Migraine: The Placebo Effect
Solomon, S. (2011) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2011.01915.x · Cited by 22
Focused hypnotic analgesia: Local and remote effects
Sharav, Y., & Tal, M. (2006) · Pain · doi:10.1016/j.pain.2006.04.016 · Cited by 21
Mindfulness-Based Analgesia or Placebo Effect? The Development and Evaluation of a Sham Mindfulness Intervention for Acute Experimental Pain
Davies, J. N., Sharpe, L., Day, M. A., & Colagiuri, B. (2020) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000886 · Cited by 20
Impact of lifestyle intervention on body weight and the metabolic syndrome in home-care providers
Gerstel, E., Pataky, Z., Busnel, C., Rutschmann, O., Guessous, I., Zumwald, C., & Golay, A. (2012) · Diabetes & Metabolism · doi:10.1016/j.diabet.2012.07.003 · Cited by 20
The effects of a gamified approach avoidance training and verbal suggestions on food outcomes
Schakel, L., Veldhuijzen, D. S., van Middendorp, H., Dessel, P. V., Houwer, J. D., Rafael Bidarra, E., & Evers, A. W. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201309 · Cited by 20
Mechanisms associated with unusual orofacial pain.
Lavigne, G. J., Woda, A., Truelove, E. L., Ship, J. A., Dao, T. T. T., & Goulet, J. (2005) · PubMed · Cited by 20
Effects of coping statements on experimental pain in chronic pain patients
Roditi, D. (2009) · Journal of Pain Research · doi:10.2147/jpr.s6357 · Cited by 19

Authors: Pollo, A., Amanzio, M., Arslanian, A., Casadio, C., Maggi, G., & Benedetti, F.
Affiliations: University of Turin (IT)
Corresponding author: Benedetti, Fabrizio
ORCID: Pollo, Antonella
Amanzio, Martina
Benedetti, Fabrizio
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2001-07
Volume: 93
Issue: 1
Pages: 77-84
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/s0304-3959(01)00296-2
OpenAlex: W1987206591
Cited by: 442
References: 25
Citations by year: 2026: 4 · 2025: 11 · 2024: 12 · 2023: 16 · 2022: 11 · 2021: 8 · 2020: 29 · 2019: 16 · 2018: 24 · 2017: 27 · 2016: 17 · 2015: 23 · 2014: 25 · 2013: 20 · 2012: 20
FWCI: 6.64
Type: journal article
Language: en
Open access: closed
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Funders: Centre National de la Recherche Scientifique
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords: placebo analgesia, response expectancy, placebo effect, buprenorphine, thoracotomy, verbal instructions, deception
MeSH terms: Aged, Analgesics, Analgesics, Opioid, Buprenorphine, Double-Blind Method, Female, Humans, Male, Middle Aged, Postoperative Pain, Placebo Effect

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Response expectancies in placebo analgesia and their clinical relevance

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks