The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Oxygen free radical generating mechanisms in the colon: do the semiquinones of vitamin K play a role in the aetiology of colon cancer?
Abstract
It is proposed that bile acids (deoxycholic acid), the K vitamins, iron(II) complexes and oxygen interact to induce an oncogenic effect in the colon by the generation of free radicals. In the relatively low oxidising/reducing conditions of the colonic lumen the K vitamins exist in the reduced form; however, if absorbed into the mucosa they have the capacity to be chemically oxidised and to enter into a redox cycle yielding oxygen radicals. The semiquinone radical of K(1) (phylloquinone) has been stabilised in bile acid mixed micelles and investigated by electron paramagnetic resonance spectroscopy and quantum chemical calculations. The estimated half-life of the radical was about 30 min which confirms a remarkably high stability in aqueous micellar solution. A model is presented in which the reduced K vitamins may initiate superoxide radical, O2(-*) generation leading to Fe(II) mediated Fenton reactions in the stem colon cells.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Red meat contains high content of iron which may catalyze ROS formation in the colon in the process of digestion (Valko et al. 2001).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Valko et al. 2001
In the citing paper
“A positive correlation between the high consumption of red meat and the incidence of colon cancer has been proposed (Valko et al. 2001).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Valko et al. 2001
Citations
Cites
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Dewar, M. J., Zoebisch, E., Healy, E. F., & Stewart, J. (1985) · Journal of the American Chemical Society · doi:10.1021/ja00299a024 · Cited by 11,560
Thor, H., Smith, M. T., Hartzell, P., Bellomo, G., Jewell, S. A., & Orrenius, S. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33730-x · Cited by 902
Narisawa, T., Magadia, N. E., Weisburger, J. H., & Wynder, E. L. (1974) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/53.4.1093 · Cited by 704
The gastrointestinal tract: A major site of antioxidant action?
Halliwell, B. B., Zhao, K., & Whiteman, M. (2000) · Free Radical Research · doi:10.1080/10715760000301341 · Cited by 518
Childhood cancer, intramuscular vitamin K, and pethidine given during labour.
Golding, J., Greenwood, R., Birmingham, K. E., & Mott, M. G. (1992) · BMJ · doi:10.1136/bmj.305.6849.341 · Cited by 329
Free radicals and the etiology of colon cancer
Babbs, C. F. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90091-v · Cited by 328
Significance of xanthine oxidase in capillary endothelial cells.
Ed, J., Bruder, G., & Heid, H. (1986) · PubMed · Cited by 325
The Physical Chemistry of Cholanic Acids
SMALL, D. M. (1971) · Springer eBooks · doi:10.1007/978-1-4757-0647-5_8 · Cited by 281
Dietary iron and colorectal cancer risk
Nelson, R. L. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90010-e · Cited by 195
Research works printed but not linked: 5
- Owen, 1977, Biochem. Soc. Trans., 5, 1171
- K. Rozman, O. Hanninen (Eds.), Gastrointestinal Toxicology, Elsevier, Amsterdam, 1986, Ch. 5.
- Jarash, 1986, Acta Physiol. Scand., 548, 39
- Reguli, 1992, Chem. Listy, 86, 807
- Reguli, 1992, Bratisl. Lek. Listy, 93, 557
Cited by
Sorted by citations
Items 101–132 of 132
Sulaimon, L. A., Ola-Mudathir, F. K., Abdullahi, B. A., Mukhtar, A. I., & Obuotor, E. M. (2021) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v11i6-s.5220 · Cited by 5
Kim, Y., Choi, Y. M., Ham, H., Jeong, H., & Lee, J. (2013) · Food Science and Biotechnology · doi:10.1007/s10068-013-0105-x · Cited by 5
Antioxidant Potential of Asparagus adscendens
Singh, M., Shrivastava, D., & Kale, R. K. (2012) · InTech eBooks · doi:10.5772/52983 · Cited by 4
Redox cycling mechanisms in the colon
Jomová, K., & Valko, M. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.05.012 · Cited by 4
Self-citationZhang, T., Sun, W., Yang, Y., Wei, Z., Bao, K., Zhang, T., Guo, X., & Li, G. (2019) · Canadian Journal of Animal Science · doi:10.1139/cjas-2018-0099 · Cited by 3
Huang, T., Li, W., Dong, X., Li, W., Jiang, M., Wang, J., & Wen, J. (2026) · Animals · doi:10.3390/ani16081171 · Cited by 2
Caracterización química y propiedades bioactivas de hongos silvestres portugeses comestibles
de Barros, L. B. (2011) · doi:10.14201/gredos.22597 · Cited by 1
A historic study that opened a new chapter in nutritional science
Lei, S., Yang, D., & Wang, M. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.131 · Cited by 1
Turan, A. (2009) · Gastroenterology Research · doi:10.4021/gr2009.03.1280 · Cited by 1
Din, M. U. (2015) · HEC National Digital Library · Cited by 1
Arteche, R. D. S. (2010) · Repositorio Institucional de la Universidad de Burgos (University of Burgos) · doi:10.36443/10259/142
The Role of Redox Signaling in the Molecular Mechanism of Tamoxifen Resistance in Breast Cancer
Garba, N. A. (2012) · FIU - Digital Commons (Florida International University) · doi:10.25148/etd.fi12041102
Cell-Sheet Technology: A Novel Method To Enhance Bone-Implant Integration
Kanuru, R. K. (2012) · eScholarship (California Digital Library)
Preto, O., Biológicas, C., & Pós-Graduação, P. D. (2014)
Modulation of human erythrocytes properties post exposed to static magnetic field
Ibrahim, I. H., Moselhy, S. S., & Khan, J. A. (2013)
Miguel, P. M. (2015) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
Khitab, U. (2020) · Pure and Applied Biology · doi:10.19045/bspab.2020.90122
Biochemical Parameters and Protein Oxidation Relationship for Hepatitis C Patients and Healthy Ones
Khitab, U., Ullah, I., Zaman, A., Ullah, S., Malik, M. I., Khan, M. S., Ullah, N., Muhammad, K., Malik, S. N., & Jilani, G. (2022) · Biological Sciences - PJSIR · doi:10.52763/pjsir.biol.sci.65.1.2022.50.54
Özel Gereksinimi Olan Çocuklarda İşitme Taramaları ve Odyolojik Değerlendirme Teknolojileri
Erdem, M. K., Karabudak, B., & Erdal, S. (2025) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub1126.c4586
Pestisitler ve Oksidatif Stres
Çelik, N. (2025) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub1126.c4588
Development of Balance Functions in Childhood and the Importance of Balance Impairments
Çolak, S. C., Buğra, E., & Cengiz, D. U. (2025) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub1126.c4590
Prevention and Intervention Approaches for Balance Impairment During the Aging Process
Çolak, S. C., Buğra, E., & Cengiz, D. U. (2025) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub1126.c4591
Sağlık Alanında Güncel Yaklaşımlar
Karakurt, P., FIRAT, M., Arıkan, A. N., Köycekaş, A., ATEŞPOLAT, Y., Bıçakçı, M. Y., Erdoğan, A. C., Karaçor, B., Elmalı, M., Çırçırlı, B., et al. (2025) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub1126
Melekoğlu, R., & Erenler, A. Ş. (2025) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub1126.c4589
Yaşlı Bireylerde Öz-Bakım Gücü, Öz-Şefkat ve Hemşirelik Yaklaşımları
Memiş, Ş. Y., & Özdemir, S. (2025) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub1126.c4594
Şiddet Eğitimi ve Merhamet Duygusu
FIRAT, M., Gökmen, B. D., & Cengiz, M. (2025) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub1126.c4587
Shu, H., Liu, X., Huang, F., Gu, Y., Liang, J., Wu, Y., Chen, L., Ji, Y. F., & zhang, Y. (2026) · International journal of medicinal mushrooms · doi:10.1615/intjmedmushrooms.2026063846
Shaheen, S., Javad, S., & Qureshi, R. (2026) · Springer eBooks · doi:10.1007/978-981-92-1471-6_5
Zhao, S., Zhang, J., Li, X., Cui, Y., Cheng, P., Zhang, Y., Hou, X., Du, B., Du, B., Song, Q., et al. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6c07000
Metadata
- Authors
- Valko, M., Morris, H., Mazúr, M., Rapta, P., & Bilton, R. F.
- Affiliations
- Slovak University of Technology in Bratislava (SK)
- Liverpool John Moores University (GB)
- Corresponding author
- Valko, Marián
- Venue
- Biochimica et Biophysica Acta (BBA) - General Subjects
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 1527
- Issue
- 3
- Pages
- 161-166
- ISSN
- 0304-4165 (ISSN-L)
- OpenAlex
- W2006276599
- Cited by
- 124
- References
- 30
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 12 · 2014: 11 · 2013: 12 · 2012: 11
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education and Science (1/733/93)
- North West Cancer Research
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
- Keywords
- oxygen free radicals, colon cancer, vitamin K, vitamin K1, semiquinone, bile acids, deoxycholic acid, iron(II) complexes, Fenton reaction, superoxide, redox cycling, colonic mucosa, radical stability, mixed micelles
- MeSH terms
- Bile Acids and Salts, Colon, Colonic Neoplasms, Diet, Electron Spin Resonance Spectroscopy, Half-Life, Humans, Intestinal Mucosa, Micelles, Models, Chemical, Oxidation-Reduction, Vitamin K 1, Quinones, Superoxides, Vitamin K, Molecular Structure
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
