Wheel running behavior is impaired by both surgical section and genetic absence of the mouse corpus callosum
Abstract
Mice lacking a corpus callosum (CC) often show little or no deficit on tests of behavior. This paper reports that on highly complex bimanual motor tasks, deficits can be found. The speed of running on a wheel with irregularly spaced rungs is reduced by both hereditary absence of the CC in 129 x BALB/c recombinant mice and surgical section of the CC in genetically normal B6D2F(2) mice. The effect of CC absence appears on measures most closely related to speed, no influence exists on the amount of running over a period of 5 days. Motor behavior on a notched balance beam, on the other hand, shows clear superiority of the hybrid mice but no relation with reduced size of the CC, whether it was produced by genotype or surgery. The effect of absent CC is task dependent, but it is not obscured by developmental compensation in the recombinant mice.
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Mice with genetic defects or lesions in the corpus callosum do not show an overt motor impairment.
“mice with genetic defects or lesions in the corpus callosum do not show an overt motor impairment (Schalomon and Wahlsten 2002).”
From Cuprizone-Dependent De/Remyelination Responses and Functional Correlates in Mouse Strains Adopted to Model Relapsing, Chronic and Progressive Experimental Autoimmune Encephalomyelitis (2021) · cites this paper as Schalomon and Wahlsten 2002
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References 45 · Cited by 42
- Authors
- Schalomon, P. M., & Wahlsten, D.
- Affiliations
- University of Alberta (CA)
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 2002-01
- Volume
- 57
- Issue
- 1
- Pages
- 27-33
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W2085164712
- Cited by
- 42
- References
- 45
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 4 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 2
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- corpus callosum, wheel running, agenesis of the corpus callosum, corpus callosum transection, motor behavior, developmental compensation, interhemispheric connectivity
- MeSH terms
- Animals, Corpus Callosum, Postural Balance, Female, Male, Mice, Neurologic Mutants, Motor Activity, Motor Skills, Nervous System Malformations, Mice, Agenesis of Corpus Callosum
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