Disruption of astroglial interlaminar processes in Alzheimer’s disease.
Abstract
A palisade of long, interlaminar astroglial processes in supragranular layers of the cerebral cortex is characteristic of adult individuals of anthropoid species. In the present study, this distinctive cytoarchitectonic feature was analyzed in tissue deriving from the neocortex of cases affected by Alzheimer's disease (n=14) and age-matched control cases (n=10). Samples of different cortical areas, and in particular prefrontal, temporal and striate fields, were analyzed. Astroglia was labeled by glial fibrillary acidic protein immunoreactivity, that allowed a clear distinction between the classical, stellate intralaminar astroglia and the interlaminar glial processes. The occurrence and relative density of neuritic plaques were ascertained in the same specimens with Bielchowsky staining. In most cortical regions of cases diagnosed as severe Alzheimer's disease by the donor institutions, interlaminar astroglia was found to be markedly altered or absent, and replaced by hypertrophic intralaminar astrocytes. Cases diagnosed as milder or uncertain Alzheimer's disease showed a less consistent involvement of the interlaminar glial palisade. Alterations of the interlaminar palisade in the cortex affected by Alzheimer's disease did not strictly correlate with the density of neuritic plaques in the examined specimens. The findings indicate that loss/severe disruption of the interlaminar palisade of astroglial processes is part of the array of neuropathological changes occurring in the…
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ILAs are not a consequence of an inflammatory state of the brain but rather an integral component of it.
“This indicates that ILAs are not a consequence of an inflammatory state of the brain but rather an integral component of it”
From Interlaminar and varicose-projection astrocytes: toward a new understanding of the primate brain (2024) · cites this paper as Colombo et al., 2002
While intralaminar astrocytes react to insults with varying levels of astrogliosis, ILAs are susceptible but not directly involved in the reaction against the disorder's development.
“While intralaminar astrocytes react to insults, with varying levels of astrogliosis (i.e., upregulation of GFAP as mRNA and protein, soma hypertrophy, increased number of processes, and loss of the organization in domains) (Escartin et al., 2021), ILAs are susceptible (Edler et al., 2023; Oberheim et al., 2006), but not directly involved in the reaction against the disorder’s development (Colombo,”
From Interlaminar and varicose-projection astrocytes: toward a new understanding of the primate brain (2024) · cites this paper as Colombo et al., 2002
In Alzheimer's disease, ILAs lose their palisade structure, although they do not directly co-localize typical neuritic plaques.
“ILAs lose their palisade structure, although they do not directly co-localize typical neuritic plaques (Colombo et al., 2002; Edler et al., 2023).”
From Interlaminar and varicose-projection astrocytes: toward a new understanding of the primate brain (2024) · cites this paper as Colombo et al., 2002
GFAP intensity in both filaments and terminal portions increases with age in all non-human primates.
“The intensity of GFAP (both in the filaments and in the terminal portions) increases with age in all non-human primates”
From Interlaminar and varicose-projection astrocytes: toward a new understanding of the primate brain (2024) · cites this paper as Colombo et al., 2002
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Interlaminar and varicose-projection astrocytes: toward a new understanding of the primate brain
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- Authors
- Colombo, J. A., Quinn, B., & Puissant, V
- Affiliations
- Northwestern University (US)
- Corresponding author
- Colombo, J.A
- ORCID
- Colombo, J.A
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 58
- Issue
- 2
- Pages
- 235-242
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W1964319708
- Cited by
- 71
- References
- 3
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 4 · 2023: 7 · 2022: 4 · 2021: 8 · 2020: 4 · 2019: 2 · 2018: 8 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Alzheimer's disease, astrocytes, glial fibrillary acidic protein, neuritic plaques, cerebral cortex, astrocyte hypertrophy, prefrontal cortex, temporal cortex, primary visual cortex
- MeSH terms
- Aged, Alzheimer Disease, Astrocytes, Female, Glial Fibrillary Acidic Protein, Humans, Immunohistochemistry, Male, Vimentin, Silver Staining, Neocortex, Cell Size, Plaque, Amyloid
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