The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Sex- and tissue-specific expression of aspartic proteinases in Danio rerio (zebrafish)
Abstract
Full-length zebrafish cDNAs encoding two aspartic proteinases were cloned and sequenced. One of the two cDNAs was a 1708 bp product with an open reading frame of 398 amino acid residues corresponding to a cathepsin D. The other was a 1383 bp product encoding a polypeptide chain of 416 amino acids homologous to nothepsin, an aspartic proteinase first identified by us in the liver of Antarctic Notothenioidei. Gene expression assessed by RT-PCR and northern blot hybridization of RNA from different tissues showed that the expression was tissue- and sex-specific. Whereas the cathepsin D gene was expressed in all the tissues examined independently of the sex, the nothepsin gene was expressed exclusively in female livers.
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“In zebrafish, this gene is specifically expressed in the liver of females under the action of oestrogens, and accumulates in the ovary 39 .”
From Genome analysis of the platypus reveals unique signatures of evolution (2008) · cites this paper as [39]
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Cited by
Genome analysis of the platypus reveals unique signatures of evolution
paper, A. L. O. A. A. T. A. A. A. T. E. O. T. (2008) · Nature · doi:10.1038/nature06936 · Cited by 719
Cathepsin D produces antimicrobial peptide parasin I from histone H2A in the skin mucosa of fish
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Use of model organisms for the study of neuronal ceroid lipofuscinosis
Bond, M., Holthaus, S.-M. K., Tammen, I., Tear, G., & Russell, C. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.01.009 · Cited by 92
Metadata
- Authors
- Riggio, M., Scudiero, R., Filosa, S., & Parisi, E.
- Affiliations
- University of Naples Federico II (IT)
- Institute of Protein Biochemistry (IT)
- Corresponding author
- Parisi, Elio
- ORCID
- Scudiero, Rosaria
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 260
- Issue
- 1-2
- Pages
- 67-75
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W1989531790
- Cited by
- 38
- References
- 30
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 2 · 2019: 1 · 2018: 3 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Keywords
- aspartic protease, cathepsin D, zebrafish, sex-specific gene expression, tissue-specific gene expression, liver, cDNA cloning, gene expression
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Cathepsin D, Female, Male, Molecular Sequence Data, Phylogeny, RNA, Sex Factors, Tissue Distribution, Zebrafish, Blotting, Northern, Gene Expression Regulation, Enzymologic, Aspartic Acid Endopeptidases, Sequence Analysis, DNA, DNA, Complementary
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- CoChat. (2026). Citation check: Sex- and tissue-specific expression of aspartic proteinases in Danio rerio (zebrafish). https://app.cochat.ai/papers/10.1016/s0378-1119(00)00469-8
- The paper
- Riggio, M., Scudiero, R., Filosa, S., & Parisi, E. (2000). Sex- and tissue-specific expression of aspartic proteinases in Danio rerio (zebrafish). Gene. https://doi.org/10.1016/s0378-1119(00)00469-8
