MDM2 — master regulator of the p53 tumor suppressor protein

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Mdm2 promotes the rapid degradation of p53

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Regulation of hdm2 by Stress-Induced hdm2alt1 in Tumor and Nontumorigenic Cell Lines Correlating with p53 Stability

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Modification of serine 392 is a critical event in the regulation of p53 nuclear export and stability

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High levels of Hdmx promote cell growth in a subset of uveal melanomas.

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Apoptosis gene profiling reveals spatio-temporal regulated expression of the p53/Mdm2 pathway during lens development

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p53

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Overexpression of mouse Mdm2 induces developmental phenotypes in Drosophila

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Advances in the targeted therapy of liposarcoma

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The role of TP53 and MDM2 polymorphisms in TP53 mutagenesis and risk of non-melanoma skin cancer

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Nanotized PPARα Overexpression Targeted to Hypertrophied Myocardium Improves Cardiac Function by Attenuating the p53-GSK3β-Mediated Mitochondrial Death Pathway

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Downregulation of free ubiquitin: a novel mechanism of p53 stabilization and neuronal cell death

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Discovery of ganoderic acid A (GAA) PROTACs as MDM2 protein degraders for the treatment of breast cancer

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Evaluation of the expression of p53, MDM 2, and SUMO ‐1 in oral lichen planus

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Relation between expression pattern of p53 and survivin in cutaneous basal cell carcinomas

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Effective co-delivery of nutlin-3a and p53 genes via core–shell microparticles for disruption of MDM2–p53 interaction and reactivation of p53 in hepatocellular carcinoma

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p53 and mdm-2 Expression in Rhabdomyosarcoma of Childhood and Adolescence: Clinicopathologic Study by the Kiel Pediatric Tumor Registry and the German Cooperative Soft Tissue Sarcoma Study

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Detection of the p53 regulator murine double-minute protein 2 in rheumatoid arthritis.

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Role of C-Terminal Residues in Oligomerization and Stability of λ CII: Implications for Lysis-Lysogeny Decision of the Phage

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Molecular and cellular mechanisms of melatonin in breast cancer

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The Role of F-Box Proteins during Viral Infection

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Boolean Network Approach to Negative Feedback Loops of the p53 Pathways: Synchronized Dynamics and Stochastic Limit Cycles

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p53: An Attractive Therapeutic Target for Cancer

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Mdm2 inhibition of p53 induces E2F1 transactivation via p21

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FOXO1 promotes cancer cell growth through MDM2-mediated p53 degradation

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N-Acylpolyamine inhibitors of HDM2 and HDMX binding to p53

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Conserved sequences in the final intron of MDM2 are essential for the regulation of alternative splicing of MDM2 in response to stress

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The Blocking of c-Met Signaling Induces Apoptosis through the Increase of p53 Protein in Lung Cancer

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Aromatic–aromatic interactions in the formation of the MDM2–p53 complex

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Macrophage migration inhibitory factor induces phosphorylation of Mdm2 mediated by phosphatidylinositol 3-kinase/Akt kinase: Role of this pathway in decidual cell survival

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Downregulation of RNF128 Predicts Progression and Poor Prognosis in Patients with Urothelial Carcinoma of the Upper Tract and Urinary Bladder

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Mdm2–SUMO1: is bigger better?

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Overexpression of Mdm2 and MdmX Fusion Proteins Alters p53 Mediated Transactivation, Ubiquitination, and Degradation

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Synthesis, Biological and In Silico Evaluation of Pure Nucleobase-Containing Spiro (Indane-Isoxazolidine) Derivatives as Potential Inhibitors of MDM2–p53 Interaction

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Kinetic Selection and Relaxation of the Intrinsically Disordered Region of a Protein upon Binding

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AaTs-1: A Tetrapeptide from Androctonus australis Scorpion Venom, Inhibiting U87 Glioblastoma Cells Proliferation by p53 and FPRL-1 Up-Regulations

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Hodgkin's lymphoma cells express alternatively spliced forms of HDM2 with multiple effects on cell cycle control

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Disorder–order transition of λ CII promoted by low concentrations of guanidine hydrochloride suggests a stable core and a flexible C‐terminus

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Pivotal Role of an Aliphatic Side Chain in the Development of an HDM2 Inhibitor

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Regulation of the Abundance of Kaposi’s Sarcoma-Associated Herpesvirus ORF50 Protein by Oncoprotein MDM2

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Independence of the prognostic value of tumor suppressor protein expression in ovarian adenocarcinomas: A multivariate analysis of expression of p53, retinoblastoma, and related proteins

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Uteroplacental insufficiency increases p53 phosphorylation without triggering the p53-MDM2 functional circuit response in the IUGR rat kidney

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The p53 Tumor Suppressor Pathway and Cancer

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Nucleolar p14ARF Overexpression in Reed-Sternberg Cells in Hodgkin's Lymphoma

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Impact of the K24N mutation on the transactivation domain of p53 and its binding to murine double-minute clone 2

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E2F1 inhibits MDM2 expression in a p53-dependent manner

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CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) and P53 mutation pattern in sporadic colorectal cancer

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Expression of Cell Cycle Regulatory Proteins and Analysis of Apoptosis in Normal Nasal Mucosa and in Nasal Polyps

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Protein−DNA Binding Correlates with Structural Thermostability for the Full-Length Human p53 Protein

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Patented small molecule inhibitors of p53–MDM2 interaction

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Recent Advancements in the Discovery of MDM2/MDM2-p53 Interaction Inhibitors for the Treatment of Cancer

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Detecting Cancer Outlier Genes with Potential Rearrangement Using Gene Expression Data and Biological Networks

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Alterations in MDM2 expression in esophageal squamous cell carcinoma: Relationship with p53 status

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β-Arrestin and Mdm2, Unsuspected Partners in Signaling from the Cell Surface

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Resistance to fludarabine-induced apoptosis in Epstein-Barr virus infected B cells

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Regulation of cell cycle by MDM2 in prostate cancer cells through Aurora Kinase-B and p21WAF1/CIP1 mediated pathways

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Understanding the Impact of Obesity on Ageing in the Radiance of DNA Metabolism

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Blockade of MDM2 with inactive Cas9 prevents epithelial to mesenchymal transition in retinal pigment epithelial cells

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Substituted piperidines as HDM2 inhibitors

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Low‐dose mithramycin exerts its anticancer effect via the p53 signaling pathway and synergizes with nutlin‐3 in gynecologic cancers

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Effect of berberine on p53 expression by TPA in breast cancer cells

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Recognition Dynamics of p53 and MDM2: Implications for Peptide Design

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TP53in adult acute lymphoblastic leukemia

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The contribution of the Trp/Met/Phe residues to physical interactions of p53 with cellular proteins

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ATM: Sounding the Double-strand Break AlarmPreprint

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Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts

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Lack of p53 Affects the Expression of Several Brain Mitochondrial Proteins: Insights from Proteomics into Important Pathways Regulated by p53

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MicroRNA-610 is downregulated in glioma cells, and inhibits proliferation and motility by directly targeting MDM2

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The Dual Roles of MAGE-C2 in p53 Ubiquitination and Cell Proliferation Through E3 Ligases MDM2 and TRIM28

Liu, Y., Cao, B., Hu, L., Ye, J., Tian, W., & He, X. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.922675 · Cited by 16

Discovery of MD-265: A Potent MDM2 Degrader That Achieves Complete Tumor Regression and Improves Long-Term Survival of Mice with Leukemia

Aguilar, A., Yang, J., Li, Y., McEachern, D., Huang, L., Razzouk, S., & Wang, S. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01818 · Cited by 16

Brain Distributional Kinetics of a Novel MDM2 Inhibitor SAR405838: Implications for Use in Brain Tumor Therapy

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PLPP/CIN-mediated Mdm2 dephosphorylation increases seizure susceptibility via abrogating PSD95 ubiquitination

Kim, J., Lee, D.-S., Kim, T. H., Park, H., Kim, M.-J., & Kang, T. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113383 · Cited by 16

Dlx3 Ubiquitination by Nuclear Mdm2 Is Essential for Dentinogenesis in Mice

Zheng, H., Fu, J., Chen, Z., Yang, G., & Yuan, G. (2022) · Journal of Dental Research · doi:10.1177/00220345221077202 · Cited by 16

Controlled Access of p53 to the Nucleus Regulates Its Proteasomal Degradation by MDM2

Davis, J. R., Mossalam, M., & Lim, C. S. (2013) · Molecular Pharmaceutics · doi:10.1021/mp300543t · Cited by 16

Lysine-Independent Turnover of Cyclin G1 Can Be Stabilized by B′α Subunits of Protein Phosphatase 2A

Li, H., Okamoto, K., Peart, M. J., & Prives, C. L. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00907-08 · Cited by 16

In vitro assays to study protein ubiquitination in transcription

Belz, T. F. (2002) · Methods · doi:10.1016/s1046-2023(02)00027-0 · Cited by 16

Elucidating the digital control mechanism for DNA damage repair with the p53–Mdm2 system: single cell data analysis and ensemble modelling

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Dynamics of p53 and Wnt cross talk

Malik, M. Z., Ali, S., Alam, M. J., Ishrat, R., & Singh, R. K. B. (2015) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2015.07.014 · Cited by 14

The cis conformation of proline leads to weaker binding of a p53 peptide to MDM2 compared to trans

Zhan, Y. A., & Ytreberg, F. M. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.03.021 · Cited by 15

Mechanism of Stapled Peptide Binding to MDM2: Possible Consequences for Peptide Design

Sim, A. Y. L., Joseph, T. L., Lane, D. P., & Verma, C. S. (2014) · Journal of Chemical Theory and Computation · doi:10.1021/ct4009238 · Cited by 15

Survivin is critically involved in VEGFR2 signaling-mediated esophageal cancer cell survival

Meng, L., Fu-hao, Z., Xiaoming, Z., Yuxiu, Z., Zhaojun, D., Bingcheng, L., Meiling, X., & Shuyan, S. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.134 · Cited by 15

Activation of p53-dependent/-independent pathways of apoptotic cell death by chelerythrine in a murine T cell lymphoma

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Blastocyst-Derived Stem Cell Populations under Stress: Impact of Nutrition and Metabolism on Stem Cell Potency Loss and Miscarriage

Yang, Y., Bolnick, A. D., Shamir, A. M., Abdulhasan, M. A., Li, Q., Parker, G. C., Puscheck, E. E., & Rappolee, D. A. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-017-9734-4 · Cited by 15

Cytohistological correlation, immunohistochemistry and Murine Double Minute Clone 2 amplification of pulmonary artery intimal sarcoma: A case report with review of literature

Harbhajanka, A., Dahoud, W., Michael, C. W., & Elliot, R. (2018) · Diagnostic Cytopathology · doi:10.1002/dc.24131 · Cited by 15

The role of NPM, p14arf and MDM2 in precursors of bronchial squamous cell carcinoma

Mascaux, C., Bex, F., Martin, B., Burny, A., Haller, A., Paesmans, M., Willard-Gallo, K. E., Ninane, V., & Sculier, J.-P. (2008) · European Respiratory Journal · doi:10.1183/09031936.00008408 · Cited by 15

Alteration of gene expression during radiation-induced resistance and tumorigenesis in NIH3T3 cells revealed by cDNA microarrays: involvement of MDM2 and CDC25B

Kang, C. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg187 · Cited by 15

B-MYB—p53-related relevant regulator for the progression of clear cell renal cell carcinoma

Nientiedt, M., Müller, K., Nitschke, K., Erben, P., Steidler, A., Porubský, Š., Popović, Z. V., Waldbillig, F., Mühlbauer, J., & KRIEGMAIR, M. C. (2020) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-020-03392-7 · Cited by 14

254 INVITED Small molecule inhibitors of the human MDM2-p53 interaction as anticancer agents

Wang, S., Shangary, S. K., Qin, Q., McEachern, D., Ding, K., Nikolovska‐Coleska, Z., Lu, Y., Malek, S. N., Guo, M., & Yang, D. (2008) · European Journal of Cancer Supplements · doi:10.1016/s1359-6349(08)72188-8

MDM2 and MDMX Regulators of p53 Activity

Momand, J. A., Aspuria, P. J., & Furuta, S. (2007) · Springer eBooks · doi:10.1007/0-387-30127-5_7 · Cited by 1

The regulation of MDM2 oncogene and its impact on human cancers

YuHan, Zhao, Haiyang, Yu, Wenwei, & Hu (2014) · 生物化学与生物物理学报：英文版 · Cited by 1

mdm-2 Inhibits the G1 Arrest and Apoptosis Functions of the p53 Tumor Suppressor Protein

Chen, J., Wu, X., Lin, J., & Levine, A. J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2445 · Cited by 348

p76MDM2 Inhibits the Ability of p90MDM2to Destabilize p53

Perry, M. E., Mendrysa, S. M., Saucedo, L. J., Tannous, P., & Holubar, M. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.5733 · Cited by 71