Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

WAF1, a potential mediator of p53 tumor suppression

El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321 · see citing works

p53 Mutations in Human Cancers

Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018 · see citing works

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., & Pease, L. R. (1989) · Gene · doi:10.1016/0378-1119(89)90358-2 · Cited by 7,354 · see citing works

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

Oltval, Z. N., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)90509-o · Cited by 6,003 · see citing works

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651 · see citing works

Induction of apoptosis in fibroblasts by c-myc protein

Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M. W., Waters, C. M., Penn, L. Z., & Hancock, D. C. (1992) · Cell · doi:10.1016/0092-8674(92)90123-t · Cited by 2,941 · see citing works

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

Lowe, S. W., Ruley, H. E., Jacks, T., & Housman, D. E. (1993) · Cell · doi:10.1016/0092-8674(93)90719-7 · Cited by 2,911 · see citing works

p53 is required for radiation-induced apoptosis in mouse thymocytes

Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864 · see citing works

Bcl-2 and the regulation of programmed cell death

Reed, J. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.1.1 · Cited by 2,287 · see citing works

Thymocyte apoptosis induced by p53-dependent and independent pathways

Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., & Wyllie, A. H. (1993) · Nature · doi:10.1038/362849a0 · Cited by 2,271 · see citing works

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

Miyashita, T., Krajewski, S., Krajewska, M., Wang, H., Lin, H., Liebermann, D. A., Hoffman‐Liebermann, B., & Reed, J. C. (1994) · PubMed · Cited by 2,143 · see citing works

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

Yonish-Rouach, E., Resnftzky, D., Lotem, J., Sachs, L., Kimchi, A., & Oren, M. (1991) · Nature · doi:10.1038/352345a0 · Cited by 2,079 · see citing works

Definition of a consensus binding site for p53

El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985 · see citing works

p53 function and dysfunction

Vogelstein, B. (1992) · Cell · doi:10.1016/0092-8674(92)90421-8 · Cited by 1,862 · see citing works

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

Blackwood, E. M., & Eisenman, R. N. (1991) · Science · doi:10.1126/science.2006410 · Cited by 1,681 · see citing works

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

Novack, D. V., Sorenson, C. M., Shutter, J. R., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)80065-m · Cited by 1,628 · see citing works

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

Yin, X.-M., Oltvai, Z., & Korsmeyer, S. (1994) · Nature · doi:10.1038/369321a0 · Cited by 1,383 · see citing works

Apoptosis in cancer therapy: Crossing the threshold

Fisher, D. E. (1994) · Cell · doi:10.1016/0092-8674(94)90518-5 · Cited by 1,315 · see citing works

Apoptotic cell death induced by c-myc is inhibited by bcl-2

Bissonnette, R. P., Echeverri, F., Mahboubi, A., & Green, D. R. (1992) · Nature · doi:10.1038/359552a0 · Cited by 957 · see citing works

Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

Kern, S. E., Pietenpol, J., Thiagalingam, S., Seymour, A., Kinzler, K. W., & Vogelstein, B. (1992) · Science · doi:10.1126/science.1589764 · Cited by 940 · see citing works

Regulation of the specific DNA binding function of p53

Hupp, T. R., Meek, D. W., Midgley, C., & Lane, D. P. (1992) · Cell · doi:10.1016/0092-8674(92)90562-q · Cited by 905 · see citing works

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

Symonds, H., Krall, L., Remington, L., Saenz-Robles, M., Lowe, S., Jacks, T., & Van Dyke, T. (1994) · Cell · doi:10.1016/0092-8674(94)90534-7 · Cited by 880 · see citing works

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

Askew, D. S., Ashmun, R. A., Simmons, B. C., & Cleveland, J. L. (1991) · PubMed · Cited by 867 · see citing works

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

Shaw, P. H., Bovey, R., Tardy, S., Sahli, R., Sordat, B., & Costa, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4495 · Cited by 848 · see citing works

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

Caelles, C., Helmberg, A., & Karin, M. (1994) · Nature · doi:10.1038/370220a0 · Cited by 843 · see citing works

p53 and E2F-1 cooperate to mediate apoptosis.

Wu, X., & Levine, A. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3602 · Cited by 836 · see citing works

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

Lü, X. (1993) · Cell · doi:10.1016/0092-8674(93)90496-d · Cited by 772 · see citing works

Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites

Zervos, A. S., Gyuris, J., & Brent, R. (1993) · Cell · doi:10.1016/0092-8674(93)90662-a · Cited by 769 · see citing works

Identification of a p53-dependent negative response element in the bcl-2 gene.

Miyashita, T., Harigai, M., Hanada, M., & Reed, J. C. (1994) · PubMed · Cited by 746 · see citing works

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

Thor, A. D., Moore, D. H., Edgerton, S. M., Kawasaki, E. S., Reihsaus, E., Lynch, H. T., Marcus, J. N., Schwartz, L. H., Chen, L.-C., Mayall, B. H., et al. (1992) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/84.11.845 · Cited by 721 · see citing works

Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity

Ayer, D. E., Kretzner, L., & Eisenman, R. N. (1993) · Cell · doi:10.1016/0092-8674(93)90661-9 · Cited by 697 · see citing works

Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.

Krajewski, S., Krajewska, M., Shabaik, A. S., Miyashita, T., Wang, H., & Reed, J. C. (1994) · PubMed Central · Cited by 657 · see citing works

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

Sato, T., Hanada, M., Bodrug, S., Irie, S., Iwama, N., Boise, L., Thompson, C. B., Golemis, E. A., Fong, L. E., & Wang, H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.20.9238 · Cited by 586 · see citing works

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.

Selvakumaran, M., Lin, H. K., Miyashita, T., et al. (1994) · PubMed · Cited by 482 · see citing works

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

Mercer, W. E., Shields, M. T., Amin, M., Sauvé, G. J., Appella, E., Romano, J., & Ullrich, S. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.16.6166 · Cited by 477 · see citing works

Induction of Cellular p53 Activity by DNA-Damaging Agents and Growth Arrest

Zhan, Q., Carrier, F., & Fornace, A. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.4242 · Cited by 441 · see citing works

Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice

Nakayama, K., Nakayama, K., Negishi, I., Kuida, K., Shinkai, Y., Louie, M. C., Fields, L. E., Lucas, P. J., Stewart, V., Alt, F. W., et al. (1993) · Science · doi:10.1126/science.8372353 · Cited by 394 · see citing works

Small Subgroup of Aggressive, Highly Proliferative Prostatic Carcinomas Defined by p53 Accumulation

Visakorpi, T., Kallioniemi, O., Heikkinen, A., et al. (1992) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/84.11.883 · Cited by 312 · see citing works

Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma

Sun, X., Carstensen, J. M., Stål, O., et al. (1992) · The Lancet · doi:10.1016/0140-6736(92)92558-w · Cited by 224 · see citing works

c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle.

Ryan, J. J., Prochownik, E. V., Gottlieb, C. A., Apel, I. J., Merino, R., Núñez, G., & Clarke, M. F. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.13.5878 · Cited by 208 · see citing works

Reversal of Chemoresistance of Lymphoma Cells by Antisense-Mediated Reduction of bcl -2 Gene Expression

Kitada, S., Takayama, S.-I. J., Riel, K. D., et al. (1994) · Antisense Research and Development · doi:10.1089/ard.1994.4.71 · Cited by 190 · see citing works

Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma line.

Wang, Y., Székely, L., Okan, İ., et al. (1993) · PubMed · Cited by 180 · see citing works

Mammalian p53 can function as a transcription factor in yeast

Scharer, E., & lggo, R. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.7.1539 · Cited by 177 · see citing works

Down‐regulation of wild‐type p53 activity interferes with apoptosis of IL‐3‐dependent hematopoietic cells following IL‐3 withdrawal.

Gottlieb, E., Haffner, R., von Rüden, T., Wagner, E. F., & Oren, M. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06390.x · Cited by 162 · see citing works

Bovine papillomavirus transcriptional regulation: localization of the E2-responsive elements of the long control region

Spalholz, B. A., Lambert, P. F., Yee, C., et al. (1987) · Journal of Virology · doi:10.1128/jvi.61.7.2128-2137.1987 · Cited by 153 · see citing works

The helix-loop-helix/leucine repeat transcription factor USF can be functionally regulated in a redox-dependent manner.

Pognonec, P., Kato, H., & Roeder, R. G. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35801-0 · Cited by 127 · see citing works

Investigations of Antisense Oligonucleotides Targeted Against bcl-2 RNAs

Kitada, S., Miyashita, T., Tanaka, S., et al. (1993) · Antisense Research and Development · doi:10.1089/ard.1993.3.157 · Cited by 95 · see citing works

Mutant p53 increases radioresistance in rat embryo fibroblasts simultaneously transfected with HPV16-E7 and/or activated H-ras.

Bristow, R. G., Jang, A., Peacock, J. W., et al. (1994) · PubMed · Cited by 81 · see citing works

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system

(1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1794-b · Cited by 32 · see citing works

p53, the cellular gatekeeper for growth and division

Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693 · see citing works

Cancer Cell Cycles

Sherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379 · see citing works

Cellular survival: a play in three Akts

Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216 · see citing works

Mitochondrial membrane permeabilization in cell death

Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598 · see citing works

A microRNA component of the p53 tumour suppressor network

He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., et al. (2007) · Nature · doi:10.1038/nature05939 · Cited by 2,692 · see citing works

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559 · see citing works

Brain corticosteroid receptor balance in health and disease

de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614 · see citing works

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

Nakano, K., & Vousden, K. H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00214-3 · Cited by 2,315 · see citing works

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P. (1995) · Cell · doi:10.1016/0092-8674(95)90039-x · Cited by 2,113 · see citing works

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

Oda, E., Ohki, R., Murasawa, H., Nemoto, J., Shibue, T., Yamashita, T., Tokino, T., Taniguchi, T., & Tanaka, †. N. (2000) · Science · doi:10.1126/science.288.5468.1053 · Cited by 2,112 · see citing works

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

Singh, R., Letai, A., & Sarosiek, K. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0089-8 · Cited by 2,111 · see citing works

Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

Chipuk, J. E., Kuwana, T., Bouchier-Hayes, L., Droin, N. M., Newmeyer, D. D., Schuler, M., & Green, D. R. (2004) · Science · doi:10.1126/science.1092734 · Cited by 2,066 · see citing works

The first 30 years of p53: growing ever more complex.

Levine, A. J., & Oren, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2723 · Cited by 1,967 · see citing works

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

Honda, R., Tanaka, H., & Yasuda, H. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01480-4 · Cited by 1,951 · see citing works

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

de Oca Luna, R. M., Wagner, D. S., & Lozano, G. (1995) · Nature · doi:10.1038/378203a0 · Cited by 1,420 · see citing works

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

Kawamura, T., Suzuki, J., Wang, Y. V., Menendez, S., Morera, L. B., Raya, A., Wahl, G. M., & Belmonte, J. C. I. (2009) · Nature · doi:10.1038/nature08311 · Cited by 1,115 · see citing works

Census and evaluation of p53 target genes

Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971 · see citing works

Targeting p53 pathways: mechanisms, structures, and advances in therapy

Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016 · see citing works

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

Liu, L., Scolnick, D. M., Trievel, R. C., Zhang, H. B., Marmorstein, R., Halazonetis, T. D., & Berger, S. L. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1202 · Cited by 776 · see citing works

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

Chen, X., Ko, L. J., Jayaraman, L., & Prives, C. (1996) · Genes & Development · doi:10.1101/gad.10.19.2438 · Cited by 735 · see citing works

Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

Honda, R., & Yasuda, H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.1.22 · Cited by 724 · see citing works

A Proinflammatory Cytokine Inhibits P53 Tumor Suppressor Activity

Hudson, J. D., Shoaibi, M. A., Maestro, R., Carnero, A., Hannon, G. J., & Beach, D. H. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.10.1375 · Cited by 649 · see citing works

MDM2 — master regulator of the p53 tumor suppressor protein

Momand, J., Wu, H.-H., & Dasgupta, G. (2000) · Gene · doi:10.1016/s0378-1119(99)00487-4 · Cited by 641 · see citing works

The mitochondrial pathways of apoptosis

Estaquier, J., Vallette, F., Vayssiere, J.-L., & Mignotte, B. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_7 · Cited by 637 · see citing works

Transcriptional Cross Talk between NF-κB and p53

Webster, G. A., & Perkins, N. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3485 · Cited by 598 · see citing works

Transcriptional regulation of bcl-2 by nuclear factor κB and its significance in prostate cancer

Catz, S. D., & Johnson, J. L. (2001) · Oncogene · doi:10.1038/sj.onc.1204926 · Cited by 538 · see citing works

DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis

Bernstein, C. (2002) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(02)00009-1 · Cited by 527 · see citing works

p53 and E2f: partners in life and death

Polager, S., & Ginsberg, D. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2718 · Cited by 498 · see citing works

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

Gaiddon, C., Lokshin, M., Ahn, J., Zhang, T., & Prives, C. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.5.1874-1887.2001 · Cited by 464 · see citing works

BID regulation by p53 contributes to chemosensitivity

Sax, J. K., Fei, P., Murphy, M. E., Bernhard, E., Korsmeyer, S. J., & El-Deiry, W. S. (2002) · Nature Cell Biology · doi:10.1038/ncb866 · Cited by 420 · see citing works

Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

Lehmann, S., Bykov, V. J. N., Ali, D., Andrén, O., Cherif, H., Tidefelt, U., Uggla, B., Yachnin, J., Juliusson, G., Moshfegh, A., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.40.7783 · Cited by 406 · see citing works

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

Tao, W., & Levine, A. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3077 · Cited by 355 · see citing works

Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site

Takimoto, R., & El-Deiry, W. S. (2000) · Oncogene · doi:10.1038/sj.onc.1203489 · Cited by 360 · see citing works

SAR405838: An Optimized Inhibitor of MDM2–p53 Interaction That Induces Complete and Durable Tumor Regression

Wang, S., Sun, W., Zhao, Y., McEachern, D., Meaux, I., Barrière, C., Stuckey, J. A., Meagher, J. L., Bai, L., Liu, L., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0799 · Cited by 328 · see citing works

MDM2 suppresses p73 function without promoting p73 degradation

Zeng, X., Chen, L., Jost, C. A., Maya, R., Keller, D., Wang, X., Kaelin, W. G., Oren, M., Chen, J., & Lu, H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3257 · Cited by 334 · see citing works

Influence of Induced Reactive Oxygen Species in p53-Mediated Cell Fate Decisions

Macip, S., Igarashi, M., Berggren, P., Yu, J., Lee, S. W., & Aaronson, S. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.23.8576-8585.2003 · Cited by 331 · see citing works

ATR-Chk2 Signaling in p53 Activation and DNA Damage Response during Cisplatin-induced Apoptosis

Pabla, N., Huang, S., Mi, Q.-S., Daniel, R., & Dong, Z. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707568200 · Cited by 309 · see citing works

TAp63α induces apoptosis by activating signaling via death receptors and mitochondria

Gressner, O., Schilling, T., Lorenz, K., Schulze Schleithoff, E., Koch, A., Schulze‐Bergkamen, H., Maria Lena, A., Candi, E., Terrinoni, A., Valeria Catani, M., et al. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600708 · Cited by 255 · see citing works

Placental Transforming Growth Factor-β Is a Downstream Mediator of the Growth Arrest and Apoptotic Response of Tumor Cells to DNA Damage and p53 Overexpression

Li, P.-X., Wong, J., Ayed, A., Ngo, D., Brade, A. M., Arrowsmith, C., Austin, R. C., & Klamut, H. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909580199 · Cited by 254 · see citing works

Akt Activation Protects Hippocampal Neurons from Apoptosis by Inhibiting Transcriptional Activity of p53

Yamaguchi, A., Tamatani, M., Matsuzaki, H., Namikawa, K., Kiyama, H., Vitek, M. P., Mitsuda, N., & Tohyama, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008552200 · Cited by 242 · see citing works

p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase

Zhao, Y., Chaiswing, L., Velez, J. M., Batinic-Haberle, I., Colburn, N. H., Oberley, T. D., & St. Clair, D. K. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3835 · Cited by 245 · see citing works

Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression

Ambs, S., Hussain, S. P., & Harris, C. C. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.6.9194524 · Cited by 233 · see citing works

Apoptosis of Retinal Ganglion Cells in Glaucoma

Nickells, R. W. (1999) · Survey of Ophthalmology · doi:10.1016/s0039-6257(99)00029-6 · Cited by 232 · see citing works

Replicative Senescence of Activated Human Hepatic Stellate Cells Is Accompanied by A Pronounced Inflammatory But Less Fibrogenic Phenotype

Schnabl, B., Purbeck, C. A., Choi, Y. H., Hagedorn, C. H., & Brenner, D. (2003) · Hepatology · doi:10.1053/jhep.2003.50097 · Cited by 224 · see citing works

A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains.

Zapata, J. M., Pawlowski, K., Haas, E., Ware, C. F., Godzik, A., & Reed, J. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100354200 · Cited by 228 · see citing works

Negative regulation of bcl-2 expression by p53 in hematopoietic cells

Wu, Y.-L., Mehew, J. W., Heckman, C. A., Arcinas, M., & Boxer, L. M. (2001) · Oncogene · doi:10.1038/sj.onc.1204067 · Cited by 221 · see citing works

MdmX Protects p53 from Mdm2-Mediated Degradation

Jackson, M. W., & Berberich, S. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.1001-1007.2000 · Cited by 211 · see citing works

Mdm2 binds p73α without targeting degradation

Bálint, E., Bates, S., & Vousden, K. H. (1999) · Oncogene · doi:10.1038/sj.onc.1202781 · Cited by 212 · see citing works

The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis

Liu, G., & Chen, X. (2002) · Oncogene · doi:10.1038/sj.onc.1205862 · Cited by 207 · see citing works

The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

Cuddihy, A. R., Hoi-Tao Wong, A., Wai Ning Tam, N., Li, S., & Koromilas, A. E. (1999) · Oncogene · doi:10.1038/sj.onc.1202620 · Cited by 203 · see citing works

Intact p53-Dependent Responses in miR-34–Deficient Mice

Concepcion, C. P., Han, Y.-C., Mu, P., Bonetti, C., Yao, E., D'Andrea, A., Vidigal, J. A., Maughan, W. P., Ogrodowski, P., & Ventura, A. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002797 · Cited by 197 · see citing works

ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth

Fan, F., Jin, S., Amundson, S. A., Tong, T., Fan, W., Zhao, H., Zhu, X., Mazzacurati, L., Li, X., Petrik, K. L., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205896 · Cited by 198 · see citing works

Regulation of AIF expression by p53

Stambolsky, P., Weisz, L., Shats, I., Klein, Y., Goldfinger, N., Oren, M., & Rotter, V (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401965 · Cited by 194 · see citing works

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death

Fortin, A., Cregan, S. P., MacLaurin, J. G., Kushwaha, N., Hickman, E. S., Thompson, C. S., Hakim, A., Albert, P. R., Cecconi, F., Helin, K., et al. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200105137 · Cited by 194 · see citing works

Presenilin-Dependent  -Secretase-Mediated Control of p53-Associated Cell Death in Alzheimer's Disease

Alves da Costa, C., Sunyach, C., Pardossi-Piquard, R., Sevalle, J., Vincent, B., Boyer, N., Kawarai, T., Girardot, N., St. George-Hyslop, P., & Checler, F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0651-06.2006 · Cited by 168 · see citing works

Genome Stability Requires p53

Eischen, C. M. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026096 · Cited by 161 · see citing works

Hdmx Stabilizes Mdm2 and p53

Stad, R., Ramos, Y. F. M., Little, N., Grivell, S., Attema, J., van der Eb, A. J., & Jochemsen, A. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003496200 · Cited by 145 · see citing works

Expression of CD39 on activated T cells impairs their survival in older individuals

Fang, F., Yu, M., Cavanagh, M. M., Hutter Saunders, J., Qi, Q., Ye, Z., Le Saux, S., Sultan, W., Turgano, E., Dekker, C. L., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.002 · Cited by 138 · see citing works

p53 Induces Myocyte Apoptosis via the Activation of the Renin–Angiotensin System

Pierzchalski, P., Reiss, K., Cheng, W., Cirielli, C., Kajstura, J., Nitahara, J. A., Rizk, M., Capogrossi, M. C., & Anversa, P. (1997) · Experimental Cell Research · doi:10.1006/excr.1997.3604 · Cited by 135 · see citing works

A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes

Thornborrow, E. C., Patel, S., Mastropietro, A. E., Schwartzfarb, E. M., & Manfredi, J. J. (2002) · Oncogene · doi:10.1038/sj.onc.1205069 · Cited by 132 · see citing works

Human and Mouse Fas (APO-1/CD95) Death Receptor Genes Each Contain a p53-responsive Element That Is Activated by p53 Mutants Unable to Induce Apoptosis

Munsch, D., Watanabe-Fukunaga, R., Bourdon, J.-C., Nagata, S., May, E., Yonish-Rouach, E., & Reisdorf, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.3867 · Cited by 131 · see citing works

Triiodothyronine prevents cardiac ischemia/reperfusion mitochondrial impairment and cell loss by regulating miR30a/p53 axis

Forini, F., Kusmic, C., Nicolini, G., Mariani, L., Zucchi, R., Matteucci, M., Iervasi, G., & Pitto, L. (2014) · Endocrinology · doi:10.1210/en.2014-1106 · Cited by 132 · see citing works

Mdm2 haplo‐insufficiency profoundly inhibits Myc‐induced lymphomagenesis

Alt, J. R., Greiner, T. C., Cleveland, J. L., & Eischen, C. M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg133 · Cited by 129 · see citing works

The Biological Functions and Signaling Mechanisms of the p75 Neurotrophin Receptor

Kraemer, B. R., Yoon, S. O., & Carter, B. D. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-45106-5_6 · Cited by 125 · see citing works

Increased Sensitivity to UV Radiation in Mice with a p53 Point Mutation at Ser389

Bruins, W., Zwart, E., Attardi, L. D., Iwakuma, T., Hoogervorst, E. M., Beems, R. B., Miranda, B., van Oostrom, C. T. M., van den Berg, J., van den Aardweg, G. J., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.8884-8894.2004 · Cited by 121 · see citing works

Proteolytic Cleavage of the mdm2 Oncoprotein during Apoptosis

Chen, L., Marechal, V., Moreau, J., Levine, A. J., & Chen, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22966 · Cited by 121 · see citing works

Wild-Type Human p53 Transactivates the Human Proliferating Cell Nuclear Antigen Promoter

Shivakumar, C. V., Brown, D. R., Deb, S., & Deb, S. P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6785 · Cited by 120 · see citing works

Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence.

Krones-Herzig, A., Adamson, E., & Mercola, D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2628034100 · Cited by 118 · see citing works

Regulation of Apoptosis in Myeloid Cells by Interferon Consensus Sequence–Binding Protein

Gabriele, L., Phung, J., Fukumoto, J., Segal, D., Wang, I.-M., Giannakakou, P., Giese, N. A., Ozato, K., & Morse, H. C. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.3.411 · Cited by 114 · see citing works

Retinoic Acid Increases the Expression of p53 and Proapoptotic Caspases and Sensitizes Keratinocytes to Apoptosis

Mrass, P., Rendl, M., Mildner, M., Gruber, F., Lengauer, B., Ballaun, C., Eckhart, L., & Tschachler, E. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1129 · Cited by 112 · see citing works

Analysis of Wild-Type and Mutant p21 <i> ^WAF-1 </i> Gene Activities

Lin, J., Reichner, C., Wu, X., & J. Levine, A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1786 · Cited by 111 · see citing works

Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage

Zaky, A., Busso, C., Izumi, T., Chattopadhyay, R., Bassiouny, A., Mitra, S., & Bhakat, K. K. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkm1173 · Cited by 111 · see citing works

Effects of Oxygen on Cell Turnover and Expression of Regulators of Apoptosis in Human Placental Trophoblast

Heazell, A. E. P., Lacey, H. A., Jones, C. J. P., Huppertz, B., Baker, P. N., & Crocker, I. P. (2008) · Placenta · doi:10.1016/j.placenta.2007.11.002 · Cited by 104 · see citing works

DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways

Du, F., Sun, L., Chu, Y., Li, T., Lei, C., Wang, X., Jiang, M., Min, Y., Lu, Y., Zhao, X., et al. (2018) · Cancer Communications · doi:10.1186/s40880-018-0315-y · Cited by 103 · see citing works

DNA Polymerase η, the Product of the Xeroderma Pigmentosum Variant Gene and a Target of p53, Modulates the DNA Damage Checkpoint and p53 Activation

Liu, G., & Chen, X. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.4.1398-1413.2006 · Cited by 104 · see citing works

The <i>HAUSP</i> gene plays an important role in non‐small cell lung carcinogenesis through p53‐dependent pathways

Masuya, D., Huang, C., Liu, D., Nakashima, T., Yokomise, H., Ueno, M., Nakashima, N., & Sumitomo, S. (2006) · The Journal of Pathology · doi:10.1002/path.1931 · Cited by 103 · see citing works

Optineurin suppression causes neuronal cell death via <scp>NF</scp>‐κB pathway

Akizuki, M., Yamashita, H., Uemura, K., Maruyama, H., Kawakami, H., Ito, H., & Takahashi, R. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12326 · Cited by 96 · see citing works

A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1

Rozenfeld-Granot, G., Krishnamurthy, J., Kannan, K., Toren, A., Amariglio, N., Givol, D., & Rechavi, G. (2002) · Oncogene · doi:10.1038/sj.onc.1205218 · Cited by 72 · see citing works

Inhibition of CBP-Mediated Protein Acetylation by the Ets Family Oncoprotein PU.1

Hong, W., Kim, A. Y., Ky, S., Rakowski, C., Seo, S.-B., Chakravarti, D., Atchison, M., & Blobel, G. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3729-3743.2002 · Cited by 71 · see citing works

De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation

Panjarian, S., Kozhaya, L., Arayssi, S., Yehia, M., Bielawski, J., Bielawska, A., Usta, J., Hannun, Y. A., Obeid, L. M., & Dbaibo, G. S. (2008) · Prostaglandins &amp; Other Lipid Mediators · doi:10.1016/j.prostaglandins.2008.02.004 · Cited by 69 · see citing works

Progressive apoptosis resistance prior to senescence and control by the anti-apoptotic protein BCL-xL

Rochette, P. J., & Brash, D. E. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.12.007 · Cited by 68 · see citing works

Aβ[25–35] Peptide and Iron Promote Apoptosis in Lymphocytes by an Oxidative Stress Mechanism: Involvement of H2O2, Caspase-3, NF-κB, p53 and c-Jun

Velez-Pardo, C., Garcia Ospina, G., & Jimenez del Rio, M. (2002) · NeuroToxicology · doi:10.1016/s0161-813x(02)00081-5 · Cited by 63 · see citing works

Influence of apoptosis on neurological outcome following traumatic cerebral contusion

Nathoo, N., Narotam, P. K., Agrawal, D. K., Connolly, C. A., van Dellen, J. R., Barnett, G. H., & Chetty, R. (2004) · Journal of Neurosurgery · doi:10.3171/jns.2004.101.2.0233 · Cited by 62 · see citing works

Identification and Characterization of the Cytoplasmic Protein TRAF4 as a p53-regulated Proapoptotic Gene

Sax, J. K., & El-Deiry, W. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303191200 · Cited by 60 · see citing works

Genotoxic stress/p53-induced DNAJB9 inhibits the pro-apoptotic function of p53

Lee, H. J., Kim, J. M., Kim, K. H., Heo, J. I., Kwak, S. J., & Han, J. A. (2015) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2014.116 · Cited by 60 · see citing works

Hypoxia Promotes Acquisition of Aggressive Phenotypes in Human Malignant Mesothelioma

Kim, M.-C., Hwang, S.-H., Kim, N.-Y., Lee, H.-S., Ji, S., Yang, Y., & Kim, Y. (2018) · BMC Cancer · doi:10.1186/s12885-018-4720-z · Cited by 49 · see citing works

Helping the released guardian: Drug combinations for supporting the anticancer activity of HDM2 (MDM2) antagonists

Kocik, J., Machula, M., Wisniewska, A., Surmiak, E., Holak, T. A., & Skalniak, L. (2019) · Cancers · doi:10.3390/cancers11071014 · Cited by 46 · see citing works

Inhaled Asbestos Fibers Induce p53 Expression in the Rat Lung

Mishra, A., Liu, J. Y., Brody, A. R., & Morris, G. F. (1997) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.16.4.9115760 · Cited by 47 · see citing works

Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization

Gama, V, Gomez, J. A., Mayo, L. D., Jackson, M. W., Danielpour, D., Song, K., Haas, A. L., Laughlin, M. J., & Matsuyama, S. (2009) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2009.6 · Cited by 46 · see citing works

Full-length hdmX transcripts decrease following genotoxic stress

Markey, M., & Berberich, S. J. (2008) · Oncogene · doi:10.1038/onc.2008.266 · Cited by 38 · see citing works

p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death

Baudot, A. D., Crighton, D., O'Prey, J., Somers, J., Sierra Gonzalez, P., & Ryan, K. M. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1191714 · Cited by 31 · see citing works

Colorectal and Prostate Cancer Risk in Diabetes: Metformin, an Actor Behind the Scene

Anwar, M. A., Kheir, W. A., Eid, S., Fares, J., Liu, X., Eid, A. H., & Eid, A. A. (2014) · Journal of Cancer · doi:10.7150/jca.9726 · Cited by 35 · see citing works

X-Chromosome-Linked Mir548am-5p is a key regulator of sex disparity in the susceptibility to mitochondria-mediated apoptosis

Matarrese, P., Tieri, P., Anticoli, S., Ascione, B., Conte, M., Franceschi, C., Malorni, W., Salvioli, S., & Ruggieri, A. (2019) · Cell Death &amp; Disease · doi:10.1038/s41419-019-1888-3 · Cited by 27 · see citing works

An improved fluor diffusion assay for chloramphenicol acetyltransferase gene expression.

Purschke, W. G., & Pk, M. (1994) · PubMed · Cited by 14 · see citing works

Functional implications of structural homologies between chloramphenicol acetyltransferase and dihydrolipoamide acetyltransferase

Guest, J. R. (1987) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1987.tb02324.x · Cited by 49 · see citing works

Foreign Gene Expression in the Mouse Testis by Localizedin VivoGene Transfer

Muramatsu, T., Shibata, O., Ryoki, S., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6361 · Cited by 121 · see citing works

Detection of Recombinant Protein Based on Reporter Enzyme Activity: Chloramphenicol Acetyltransferase

Lee, P.-Y., & Hruby, D. E. (2003) · Humana Press eBooks · doi:10.1385/0-89603-481-x:31 · Cited by 2 · see citing works

Regioselective Acetylation of C21 Hydroxysteroids by the Bacterial Chloramphenicol Acetyltransferase I

Mosa, A. A., Hutter, M. C., Zapp, J., Bernhardt, R., & Hannemann, F. (2015) · ChemBioChem · doi:10.1002/cbic.201500125 · Cited by 18 · see citing works