The DOI matches its Crossref record; 38 of the 40 references it cites were found in a registry or an index.
Development of cortisol circadian rhythm in infancy
Abstract
Background and aims Cortisol is the final product of the hypothalamus-pituitary-adrenal (HPA) axis. It is secreted in a pulsatile fashion that displays a circadian rhythm. Infants are born without a circadian rhythm in cortisol and they acquire it during their first year of life. Studies do not agree on the age of appearance of the circadian rhythm (varying between 2 weeks till the age of 9 months) nor on whether it is related to the appearance of the sleep-wake circadian rhythm. The object of the present study was to find evidence of the age of appearance of the diurnal rhythm of cortisol and to compare the results obtained by several different analysis methods on a new data set. Design and measures Cortisol was determined in salival samples of 14 normally developing infants who were followed monthly between the ages of 2 and 5 months. The data were analyzed with several previously published analysis methods as well as with Multilevel Analysis (Hierarchical Linear Modeling). Results The previously published analysis methods each produced different results when applied to the current data set. Moreover, our results indicate striking differences between young infants in both age of appearance and stability of the diurnal cortisol rhythm. Also, a link was found between the appearance of the sleep-wake circadian rhythm and the cortisol circadian rhythm. An important intraindividual variability in cortisol levels was found even after correcting for the different variables that af…
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“prenatal exposure to maternal stress hormones is linked to temperamental reactivity and stress physiology, likely through epigenetic regulation of gene expression”
From The Adaptive Calibration Model of stress responsivity (2011) · cites this paper as de Weerth et al., 2003
Citations
Cites
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Hierarchical Linear Models: Applications and Data Analysis Methods.
Goldstein, H., Bryk, A. S., & Raudenbush, S. W. (1993) · Journal of the American Statistical Association · doi:10.2307/2290750 · Cited by 3,320
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Kirschbaum, C., & Hellhammer, D. H. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90013-2 · Cited by 2,107
Salivary Cortisol in Psychobiological Research: An Overview
Kirschbaum, C., & Hellhammer, D. H. (2008) · Neuropsychobiology · doi:10.1159/000118611 · Cited by 1,532
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Van Cauter, E. (1996) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.7.2468 · Cited by 951
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Wüst, S., Federenko, I. S., Hellhammer, D. H., & Kirschbaum, C. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(00)00021-4 · Cited by 642
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Kiess, W., Meidert, A. S., Dressendörfer, R. A., Schriever, K., Kessler, U., Köunig, A., Hp, S., & Strasburger, C. J. (1995) · Pediatric Research · doi:10.1203/00006450-199504000-00020 · Cited by 325
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The Adaptive Calibration Model of stress responsivity
Del Giudice, M., Ellis, B. J., & Shirtcliff, E. A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.007 · Cited by 1,373
“…2005); likewise, prenatal exposure to maternal stress hormones is linked to temperamental reactivity and stress physiology, likely through epigenetic regulation of gene expression (de Weerth et al., 2003; Gutteling et al., 2005; Möhler et al., 2006; O’Connor et al., 2005; Poggi Davis et al., 2010).”
Prenatal depression effects on the fetus and newborn: a review
Field, T., Diego, M., & Hernandez-Reif, M. (2006) · Infant Behavior and Development · doi:10.1016/j.infbeh.2006.03.003 · Cited by 592
Measuring cortisol in serum, urine and saliva—Are our assays good enough?
El-Farhan, N., Rees, D. A., & Evans, C. (2017) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1177/0004563216687335 · Cited by 395
“In contrast, studies in saliva have demonstrated a discernible circadian rhythm in full-term neonates at 1 month of age,(142) albeit with significant intra and interindividual variability in terms of how early the rhythm appears and how persistent it is once it has appeared.(141,142,144) Further study is now needed to…”
ResultShirtcliff, E. A., Allison, A. L., Armstrong, J. M., Slattery, M. J., Kalin, N. H., & Essex, M. J. (2011) · Developmental Psychobiology · doi:10.1002/dev.20607 · Cited by 244
Prenatal mood disturbance predicts sleep problems in infancy and toddlerhood
O’Connor, T. G., Caprariello, P. A., Blackmore, E. R., Gregory, A. M., Glover, V. A. S., & Fleming, P. (2006) · Early Human Development · doi:10.1016/j.earlhumdev.2006.08.006 · Cited by 219
“First, several studies report a link between the establishment of a diurnal pattern in cortisol and sleeping through the night in infancy(44).”
Background
Metadata
- Authors
- de Weerth, C., Zijl, R. H., & Buitelaar, J. K.
- Affiliations
- University Medical Center Utrecht (NL)
- Radboud University Nijmegen (NL)
- ORCID
- Buitelaar, Jan K
- Venue
- Early Human Development
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 73
- Issue
- 1-2
- Pages
- 39-52
- ISSN
- 0378-3782 (ISSN-L)
- OpenAlex
- W2112583133
- Cited by
- 248
- References
- 40
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 12 · 2023: 13 · 2022: 12 · 2021: 9 · 2020: 15 · 2019: 12 · 2018: 8 · 2017: 15 · 2016: 18 · 2015: 22 · 2014: 17 · 2013: 14 · 2012: 10
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Early Human Development (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- cortisol, circadian rhythm, diurnal cycle, infancy, hypothalamic-pituitary-adrenal axis, salivary cortisol, sleep-wake cycle, age of onset, within-person variability, multilevel analysis
- MeSH terms
- Adult, Biological Clocks, Circadian Rhythm, Female, Humans, Hydrocortisone, Infant, Male, Pregnancy, Saliva, Sleep, Models, Statistical
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