The effect of volatile anesthetics on light-induced phosphorylation in spinach chloroplasts
Abstract
(1) The light-induced phosphorylation in spinach chloroplast is coupled with proton transfer. (2) We investigated the effect of volatile anesthetics (halothane, enflurane, isoflurane) on the cyclic and/or non-cyclic light-induced phosphorylation. (3) We used potassium ferricyanide as a Hill oxidant for non-cyclic phosphorylation and phenazin-methosulfate as an oxidation-reduction indicator for cyclic phosphorylation. (4) These three anesthetics inhibit the Hill reaction in light induced phosphorylation. The inhibition rate of this reaction generates concave curves with minimum values at 303 K in each of the anesthetics.
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Volatile anesthetics act on species across the evolutionary tree, not only on human patients.
“However, volatile anesthetics exert actions not only on human patients, but on species spanning the evolutionary tree of life [1–8] (Figure 1).”
From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [5]
Cites
COPPER ENZYMES IN ISOLATED CHLOROPLASTS. POLYPHENOLOXIDASE IN BETA VULGARIS
Arnon, D. I. (1949) · PLANT PHYSIOLOGY · doi:10.1104/pp.24.1.1 · Cited by 22,508 · see citing works
COFACTORS AND RATES OF PHOTOSYNTHETIC PHOSPHORYLATION BY SPINACH CHLOROPLASTS
Jagendorf, A. T., & Avron, M. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77304-9 · Cited by 280 · see citing works
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The Biology of General Anesthesia from Paramecium to Primate
Kelz, M. B., & Mashour, G. A. (2019) · Current Biology · doi:10.1016/j.cub.2019.09.071 · Cited by 151 · see citing works
Understanding of anesthesia – Why consciousness is essential for life and not based on genes
Baluška, F., Yokawa, K., Mancuso, S., & Baverstock, K. F. (2016) · Communicative & Integrative Biology · doi:10.1080/19420889.2016.1238118 · Cited by 76 · see citing works
A hypothesis on the origin and evolution of the response to inhaled anesthetics
Sonner, J. M. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31817ee684 · Cited by 63 · see citing works
Araki, T., Uesono, Y., Oguchi, T., & Toh‐e, A. (2005) · Genes & Genetic Systems · doi:10.1266/ggs.80.325 · Cited by 42 · see citing works
Pavlovič, A., Jakšová, J., Kučerová, Z., Špundová, M., Rác, M., Roudnický, P., & Mithöfer, A. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.995001 · Cited by 16 · see citing works
Touch, light, wounding: how anaesthetics affect plant sensing abilities
Pavlovič, A. (2024) · Plant Cell Reports · doi:10.1007/s00299-024-03369-7 · Cited by 10 · see citing works
Synchronized Chromatin Reorganization as a Key Biomarker in Anesthetic Effects on Plants
Chandra, S., Mukherjee, B., Salam, A., Anjum, F., Nandi, C. K., & Behera, L. (2026) · Chemical & Biomedical Imaging · doi:10.1021/cbmi.5c00288
Špundová, M., Kučerová, Z., Nožková, V., Savara, O., Rác, M., Gregůrková, D., & Pavlovič, A. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7590253
- Authors
- Nakao, H., Ogli, K., Yokono, S., Ono, J., & Miyatake, A.
- Affiliations
- Kagawa University (JP)
- Corresponding author
- Nakao, H.
- Venue
- Toxicology Letters
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 100-101
- Pages
- 135-138
- ISSN
- 0378-4274 (ISSN-L)
- OpenAlex
- W1980822472
- Cited by
- 8
- References
- 2
- Citations by year
- 2026: 2 · 2024: 1 · 2022: 1 · 2019: 1 · 2016: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Keywords
- volatile anesthetics, halothane, enflurane, isoflurane, chloroplasts, Hill reaction, cyclic photophosphorylation, non-cyclic photophosphorylation, proton transfer, anesthetic toxicity, spinach
- MeSH terms
- Chloroplasts, Electron Transport, Kinetics, Light, Phosphorylation, Anesthetics, Inhalation, Spinacia oleracea
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