Increased tumor growth in mice exposed to inhaled isobutyl nitrite
Abstract
Epidemiological studies have correlated the incidence of Kaposi's sarcoma (KS) in AIDS with a history of abuse of nitrite inhalants. To determine if exposure to nitrite inhalants could alter tumor growth, syngeneic PYB6 tumor cells were injected into groups of mice. Exposure of these mice to inhaled isobutyl nitrite increased both the tumor incidence and the tumor growth rate by almost 4-fold. Following only five daily exposures to the inhalant, the induction of specific T cell mediated cytotoxicity was inhibited by 36%. Similar inhalation exposures inhibited the tumoricidal activity of activated macrophages by 86%. The data suggest that exposure to abuser levels of a nitrite inhalant compromised tumor surveillance mechanisms.
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Amyl nitrite inhalant exposure led to a significant increase in tumor growth rate in mice.
“Soderberg has previously reported that amyl nitrite inhalant exposure led to a significant increase in tumor growth rate in mice [259].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [259]
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Inorganic nitrite therapy: historical perspective and future directions
Kevil, C. G., Kolluru, G. K., Pattillo, C. B., & Giordano, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.042 · Cited by 113 · see citing works
- Authors
- Soderberg, L. S. F.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- Corresponding author
- Soderberg, Lee S.F
- Venue
- Toxicology Letters
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 104
- Issue
- 1-2
- Pages
- 35-41
- ISSN
- 0378-4274 (ISSN-L)
- OpenAlex
- W2082531949
- Cited by
- 24
- References
- 20
- Citations by year
- 2018: 1 · 2017: 1 · 2015: 1 · 2012: 1
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01da006662-09)
- National Institute on Drug Abuse (DA06662)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- isobutyl nitrite, nitrite inhalants, Kaposi's sarcoma, AIDS, tumor growth, T cell cytotoxicity, tumor surveillance, immunosuppression, inhalant abuse
- MeSH terms
- Administration, Inhalation, Animals, Cell Division, Macrophages, Mice, Inbred C57BL, Neoplasm Transplantation, Nitrites, Sarcoma, Experimental, Stimulation, Chemical, Illicit Drugs, T-Lymphocytes, Cytotoxic, Tumor Cells, Cultured, Mice
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