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Cited by 60Menopause: Health Impacts and TreatmentsEstrogen and related hormone effectsHormonal and reproductive studies

Effects of 5 years of hormonal replacement therapy on menopausal symptoms and blood pressure-a randomised controlled study

Vestergaard, Peter, Hermann, Anne Pernille, Stilgren, Lis, Tofteng, Charlotte Landbo, Sørensen, Ole Helmer, Eiken, Pia, Nielsen, Stig Pors, Mosekilde, Leif·2003·Maturitas
DOI 10.1016/s0378-5122(03)00181-6
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Abstract

Objectives To study the effects of hormonal replacement on hot flushes, other symptoms linked to menopause, and blood pressure.Methods The study included 1006 early postmenopausal women aged 45-58 years, participating in the Danish Osteoporosis Prevention Study (DOPS) randomised to Hormonal replacement therapy (HRT) (n=502) or no HRT (n=504) in an open label trial. Symptom scores were recorded at baseline, after 6 month, 1, 2, and 5 years on a modified Greene scale (range 0-4 with 0 equalling no symptoms, and 4 maximal symptoms).Results HRT efficiently alleviated hot flushes (mean+/-S.E.M. score 0.48+/-0.04 in HRT vs. 0.83+/-0.05 in no HRT after 5 years, P<0.01 by repeated measures ANOVA), sleeping difficulties associated with hot flushes (0.21+/-0.60 vs. 0.37+/-0.86, P<0.01), vaginal dryness (0.45+/-0.04 vs. 0.73+/-0.05, P<0.01), dyspareunia (0.27+/-0.04 vs. 0.39+/-0.04, P<0.01), and libido (0.48+/-0.05 vs. 0.59+/-0.05, P=0.08). In the untreated group the occurrence of mood swings (from 0.77+/-0.05 at baseline to 0.45+/-0.04 after 5 years, 2P<0.01) and oedemas (from 0.59+/-0.04 to 0.43+/-0.04, 2P=0.02) decreased with age while the occurrence of incontinence increased (from 0.43+/-0.03 to 0.52+/-0.04, 2P<0.01). These changes were not influenced by HRT. Furthermore, HRT had no influence on presence of headache (0.54+/-0.05 vs. 0.58+/-0.05 after 5 years), voiding pattern (0.49+/-0.04 vs. 0.53+/-0.04), or blood pressure (mean systolic pressure 123+/-18 vs. 123+/-19, diastolic pressure 77+/-10 vs. 77+/-11).Conclusions HRT is efficient in controlling hot flushes and vaginal dryness, and symptoms related to these conditions. However, no effect on blood pressure or other menopause symptoms was recorded.

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  • Several studies comparing hormone therapy to placebo have found that hormone therapy improves perceived sleep quality and self-reported sleeping problems more than placebo.

    “Although several studies comparing HT to a placebo have found that HT improves perceived sleep quality and self-reported sleeping problems more than a placebo [112-123]”

    From Non-Pharmacological Treatment of Insomnia (2012) · cites this paper as [116]

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Authors
Vestergaard, P., Hermann, A. P., Stilgren, L., Tofteng, C. L., Sørensen, O. H., Eiken, P., Nielsen, S. P., & Mosekilde, L.
Affiliations
  • Aarhus University Hospital (DK)
  • Odense University Hospital (DK)
  • Hvidovre Hospital (DK)
  • Capital Region of Denmark (DK)
ORCID
Venue
Maturitas
Publisher
Elsevier BV
Published
2003-10
Volume
46
Issue
2
Pages
123-132
ISSN
0378-5122 (ISSN-L)
DOI
10.1016/s0378-5122(03)00181-6
OpenAlex
W2065253130
Cited by
60
References
33
Citations by year
2023: 3 · 2020: 5 · 2019: 1 · 2017: 3 · 2014: 4 · 2013: 3 · 2012: 4
FWCI
2.44
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Maturitas (publishedVersion)
  • PubMed (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
hormone replacement therapy, menopausal symptoms, hot flashes, blood pressure, postmenopausal women, vaginal dryness, dyspareunia, mood swings, urinary incontinence, headache, sleep disorders, osteoporosis prevention
MeSH terms
Blood Pressure, Denmark, Dyspareunia, Edema, Estrogens, Fecal Incontinence, Female, Follow-Up Studies, Headache, Humans, Middle Aged, Patient Compliance, Progestins, Sleep Wake Disorders, Vaginal Diseases, Cohort Studies, Estrogen Replacement Therapy, Postmenopause, Hot Flashes

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