Polysaccharides in colon-specific drug delivery
Abstract
Natural polysaccharides are now extensively used for the development of solid dosage forms for delivery of drug to the colon. The rationale for the development of a polysaccharide based delivery system for colon is the presence of large amounts of polysaccharidases in the human colon as the colon is inhabited by a large number and variety of bacteria which secrete many enzymes e.g. beta-D-glucosidase, beta-D-galactosidase, amylase, pectinase, xylanase, beta-D-xylosidase, dextranase, etc. Various major approaches utilizing polysaccharides for colon-specific delivery are fermentable coating of the drug core, embedding of the drug in biodegradable matrix, formulation of drug-saccharide conjugate (prodrugs). A large number of polysaccharides have already been studied for their potential as colon-specific drug carrier systems, such as chitosan, pectin, chondroitin sulphate, cyclodextrin, dextrans, guar gum, inulin, amylose and locust bean gum. Recent efforts and approaches exploiting these polysaccharides in colon-specific drug delivery are discussed.
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Guar gum is sensitive to microbial degradation in the large intestine.
“It is sensitive to microbial degradation in the large intestine, (Sinha and Kumria, 2001; Seeli and Prabaharan, 2016).”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Sinha and Kumria, 2001
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Rizwan, M., Yahya, R., Hassan, A., Yar, M., Azzahari, A., Selvanathan, V., Sonsudin, F., & Abouloula, C. (2017) · Polymers · doi:10.3390/polym9040137 · Cited by 844 · see citing works
Strategic approaches for colon targeted drug delivery: an overview of recent advancements
Lee, S. H., Bajracharya, R., Min, J. Y., Han, J.-W., Park, B. J., & Han, H.-K. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12010068 · Cited by 318 · see citing works
Recent advances in colon drug delivery systems
Arévalo-Pérez, R., Maderuelo, C., & Lanao, J. M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.026 · Cited by 179 · see citing works
pH-Responsive guar gum hydrogels for controlled delivery of dexamethasone to the intestine
Das, S., & Subuddhi, U. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.06.008 · Cited by 86 · see citing works
pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery.
Vegad, U., Patel, M., Khunt, D., Zupančič, O., Chauhan, S., & Paudel, A. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1270364 · Cited by 85 · see citing works
“It is sensitive to microbial degradation in the large intestine, (Sinha and Kumria, 2001; Seeli and Prabaharan, 2016).”
BackgroundBoni, F. I., Prezotti, F. G., & Cury, B. S. F. (2016) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2015.1125915 · Cited by 77 · see citing works
Todorova, V., Ivanov, K., & Ivanova, S. (2021) · Plants · doi:10.3390/plants11010064 · Cited by 56 · see citing works
- Authors
- Sinha, V. R., & Kumria, R.
- Affiliations
- Panjab University (IN)
- Corresponding author
- Sinha, V.R.
- ORCID
- Sinha, V.R.
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 224
- Issue
- 1-2
- Pages
- 19-38
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2037416813
- Cited by
- 872
- References
- 0
- Citations by year
- 2026: 23 · 2025: 25 · 2024: 28 · 2023: 40 · 2022: 41 · 2021: 46 · 2020: 46 · 2019: 42 · 2018: 46 · 2017: 43 · 2016: 46 · 2015: 46 · 2014: 43 · 2013: 50 · 2012: 46
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- colon-targeted drug delivery, natural polysaccharides, biodegradable matrices, prodrugs, polysaccharidases, chitosan, pectin, chondroitin sulfate, cyclodextrins, dextran, guar gum, inulin, amylose, locust bean gum, solid dosage forms
- MeSH terms
- Administration, Oral, Colon, Drug Carriers, Humans, Polysaccharides, Prodrugs, Molecular Structure
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