Immunomodulatory and anti-inflammatory activity of Picrorhiza scrophulariiflora
Abstract
Extracts of the rhizomes of Picrorhiza scrophulariiflora Pennell (Scrophulariaceae) were investigated for their in vitro and in vivo immunomodulatory properties. Diethyl ether extracts showed potent inhibitory activity towards the classical pathway of the complement system, the respiratory burst of activated polymorphonuclear leukocytes, and mitogen-induced proliferation of T-lymphocytes. Furthermore, such extracts showed anti-inflammatory activity towards carrageenan-induced paw edema. No effects were observed in experimentally induced arthritis in mice.
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Picroside II has been shown to possess a broad range of pharmacological effects, including an anti-oxidant and anti-inflammation property.
“Picroside II has been shown to possess a broad range of pharmacological effects, including an anti-oxidant and anti-inflammation property [21–23].”
P. scrophulariiflora has immunomodulatory and anti-inflammatory functions.
“However, it was reported that the herb has immunomodulatory and anti-inflammatory functions.”
From Neutrophilic Lung Inflammation Suppressed by Picroside II Is Associated with TGF-<i>β</i>Signaling (2015) · cites this paper as [23]
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WANG, L., LIU, X.-H., CHEN, H., CHEN, Z.-Y., WENG, X.-D., QIU, T., & LIU, L. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2225 · Cited by 46 · see citing works
Choi, J., Choi, B. K., Kim, J. S., Lee, J.-W., Park, H. A., Ryu, H. W., Lee, S. U., Hwang, K. W., Yun, W.-K., Kim, H.-C., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0167098 · Cited by 30 · see citing works
Abrigo, J., Morales, M. G., Simon, F., Cabrera, D., Capua, G. D., & Cabello-Verrugio, C. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.06.011 · Cited by 20 · see citing works
Neutrophilic Lung Inflammation Suppressed by Picroside II Is Associated with TGF-<i>β</i>Signaling
Noh, S., Ahn, K.-S., Oh, S.-R., Kim, K. H., & Joo, M. (2015) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2015/897272 · Cited by 10 · see citing works
“scrophulariiflora reduces the classical pathway of complement activation, the production of ROS by activated neutrophils, and the proliferation of T lymphocytes [23].”
BackgroundWu, P., Chang, C., Zhu, G., Zhai, L., Zhang, X., Huan, Q., Gao, Z., Deng, H., Liang, Y., & Xiao, H. (2023) · Drug Design, Development and Therapy · doi:10.2147/dddt.s407339 · Cited by 7 · see citing works
- Authors
- Smit, H. F., Kroes, B. H., van den Berg, A. J. J., van der Wal, D., van den Worm, E., Beukelman, C. J., van Dijk, H., & Labadie, R. P.
- Affiliations
- Utrecht University (NL)
- Corresponding author
- Smit, H.F
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 2000-11
- Volume
- 73
- Issue
- 1-2
- Pages
- 101-109
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W2022723653
- Cited by
- 75
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 6 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 4
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- Picrorhiza scrophulariiflora, immunomodulation, anti-inflammatory activity, rhizome extract, respiratory burst, polymorphonuclear leukocytes, T cell proliferation, mitogen-induced proliferation, carrageenan-induced paw edema, arthritis, Scrophulariaceae
- MeSH terms
- Adjuvants, Immunologic, Animals, Anti-Inflammatory Agents, Arthritis, Blood, Chromatography, High Pressure Liquid, Complement Pathway, Classical, Edema, Male, Medicine, Ayurvedic, Mice, Inbred BALB C, Plant Extracts, Respiratory Burst, Mice
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