Enhancement of bone defect healing in old rats by TGF-β and IGF-1
Abstract
Bone defects are often created in order to repair bone pathologies. In the aging population, the healing of such defects is very limited. Bone healing in aging depends on the availability of various hormone and growth factors. The ability of growth factors to enhance bone formation in femoral defects in old rats was tested. Bone defects were induced in femurs of old rats. A single dose of transforming growth factor-beta (TGF-beta), IGF-1, TGF-beta+IGF-1 or saline was inserted in the defect and bones were tested after 2 and 4 weeks. Radiology revealed that mineralization appeared in the 2 weeks group in defects treated with TGF-beta and in defects treated with TGF-beta, TGF-beta+IGF-1 in the 4 weeks groups. Computerized tomography (CT) coronal and axial images revealed that 4 weeks after treatment with TGF-beta+IGF-1, a complete bone bridge was observed. Morphology revealed that these defects were filled with trabecular bone. A less pronounced bone healing was observed after TGF-beta or IGF-1, while control specimens revealed partial healing of the bone defect. Biomechanical tests indicated that treatment with TGF-beta, IGF-1 or TGF-beta+IGF-1 resulted in a significant increase of bone bending rigidity compared to control in the 4 weeks group and that TGF-beta+IGF-1 was the most inductive in this respect. The ability to induce bone healing in aging by TGF-beta+IGF-1 is of a great clinical importance for restoration of bone strength and biomechanical properties of bone defects in aging.
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TGF-β contributes to treating bone defects in rats.
“TGF-β contributes to treating bone defects in rats [93].”
From Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature (2024) · cites this paper as [93]
Cites
Novel Regulators of Bone Formation: Molecular Clones and Activities
Wozney, J. M., Rosen, V., Celeste, A. J., Mitsock, L. M., Whitters, M. J., Kriz, R., Hewick, R. M., & Wang, E. A. (1988) · Science · doi:10.1126/science.3201241 · Cited by 3,874 · see citing works
Joyce, M. E., Roberts, A. B., Sporn, M. B., & Bolander, M. E. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.6.2195 · Cited by 732 · see citing works
Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro.
Robey, P. G., Young, M. F., Flanders, K. C., Roche, N. S., Kondaiah, P., Reddi, A. H., Termine, J. D., Sporn, M. B., & Roberts, A. B. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.1.457 · Cited by 550 · see citing works
Role of Transforming Growth Factor-Beta in Bone Remodeling
Bonewald, L. F., & Mundy, G. R. (1990) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199001000-00036 · Cited by 431 · see citing works
Decreased Pulsatile Release of Growth Hormone in Old Male Rats*
Sonntag, W. E., Steger, R. W., FORMAN, L. J., & Meites, J. (1980) · Endocrinology · doi:10.1210/endo-107-6-1875 · Cited by 276 · see citing works
Current Concepts of Fracture Healing
Hulth, A. G. (1989) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198912000-00028 · Cited by 227 · see citing works
In vivo actions of insulin-like growth factor-I (IGF-I) on bone formation and resorption in rats
Spencer, E., Liu, C. C., Si, E. C. C., & Howard, G. A. (1991) · Bone · doi:10.1016/8756-3282(91)90050-s · Cited by 222 · see citing works
Transforming growth factor-β enhances fracture healing in rabbit tibiae
Lind, M., Schumacker, B., Søballé, K., Keller, J. O., Melsen, F., & Bünger, C. E. (1993) · Acta Orthopaedica Scandinavica · doi:10.3109/17453679308993691 · Cited by 217 · see citing works
Nakamura, T., Hara, Y., TAGAWA, M., Tamura, M., Yuge, T., Fukuda, H., & Nigi, H. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.6.942 · Cited by 213 · see citing works
Gene Expression During Bone Repair
Sandberg, M., Aro, H. T., & VUORIO, E. I. (1993) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199304000-00043 · Cited by 211 · see citing works
Enhancement of bone ingrowth by transforming growth factor-beta.
Sumner, D. R., Turner, T. M., Purchio, A. F., Gombotz, W. R., Urban, R. M., & Galante, J. O. (1995) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199508000-00001 · Cited by 209 · see citing works
Local tissue properties in bone healing: Influence of size and stability of the osteotomy gap
Augat, P., Margevicius, K. J., Simon, J., Wolf, S., Suger, G., & Claes, L. (1998) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100160413 · Cited by 205 · see citing works
Local injection of TGF-β increases the strength of tibial fractures in the rat
Nielsen, H. M., Andreassen, T. T., Ledet, T., & Oxlund, H. (1994) · Acta Orthopaedica Scandinavica · doi:10.3109/17453679408993715 · Cited by 158 · see citing works
Gazit, D., Ebner, R., Kahn, A. J., & Derynck, R. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.2.8385738 · Cited by 131 · see citing works
Fracture Healing in a Rat Osteopenia Model
Walsh, W. R., Sherman, P. J., Howlett, C. R., Sonnabend, D. H., & Ehrlich, M. G. (1997) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199709000-00029 · Cited by 126 · see citing works
OSTEOINDUCTIVE GROWTH FACTORS IN PRECLINICAL FRACTURE AND LONG BONE DEFECTS MODELS
Bostrom, M. P., Saleh, K. J., & Einhorn, T. A. (1999) · Orthopedic Clinics of North America · doi:10.1016/s0030-5898(05)70117-6 · Cited by 120 · see citing works
Potential Role of Fibroblast Growth Factor in Enhancement of Fracture Healing
Radomsky, M. L., Thompson, A. Y., Spiro, R. C., & Poser, J. W. (1998) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199810001-00029 · Cited by 113 · see citing works
Age-related bone loss. A hypothesis and initial assessment in mice.
Kahn, A., Gibbons, R., Perkins, S., & Gazit, D. (1995) · PubMed · Cited by 104 · see citing works
Chemotactic response of osteoblast-like cells to transforming growth factor beta
Lucas, P. A. (1989) · Bone · doi:10.1016/8756-3282(89)90079-3 · Cited by 96 · see citing works
Zellin, G., & Linde, A. (2000) · Bone · doi:10.1016/s8756-3282(99)00252-5 · Cited by 91 · see citing works
Potential Role of Insulinlike Growth Factors in Fracture Healing
Trippel, S. B. (1998) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199810001-00031 · Cited by 90 · see citing works
Cell surface dynamics of neutrophils stimulated with phorbol esters or retinoids.
Robinson, J. M., Badwey, J. A., Karnovsky, M. J., & Karnovsky, M. J. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.1.417 · Cited by 64 · see citing works
Boonen, S., Aerssens, J., Dequeker, J., Nicholson, P., Cheng, X., Lowet, G., Verbeke, G. N., & Bouillon, R. (1997) · Calcified Tissue International · doi:10.1007/s002239900318 · Cited by 60 · see citing works
Bone loss (osteopenia) in old male mice results from diminished activity and availability of TGF-β
Gazit, D., Zilberman, Y., Ebner, R., & Kahn, A. (1998) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19980915)70:4 · Cited by 52 · see citing works
Gazit, D., Zilberman, Y., Turgeman, G., Zhou, S., & Kahn, A. J. (1999) · PubMed · Cited by 50 · see citing works
Anabolic and Tissue Repair Functions of Recombinant Insulin‐Like Growth Factor I
Skottner, A., Arrhenius‐Nyberg, V., Kanje, M., & Fryklund, L. (1990) · Acta Paediatrica · doi:10.1111/j.1651-2227.1990.tb11635.x · Cited by 45 · see citing works
Rauch, F., Lauzier, D., Travers, R., Glorieux, F. H., & Hamdy, R. C. (2000) · Bone · doi:10.1016/s8756-3282(00)00283-0 · Cited by 42 · see citing works
Effects of hormones and local growth factors on articular chondrocyte metabolism.
Franchimont, P., & Bassleer, C. (1991) · PubMed · Cited by 33 · see citing works
No effects of local somatomedin C on bone repair
Kirkeby, O. J., & Ekeland, A. (1992) · Acta Orthopaedica Scandinavica · doi:10.3109/17453679209154765 · Cited by 22 · see citing works
Quantitative Measures for Fracture Healing: An In-Vitro Biomechanical Study
Foux, A., Black, R. C., & Uhthoff, H. K. (1990) · Journal of Biomechanical Engineering · doi:10.1115/1.2891203 · Cited by 21 · see citing works
Keller, J. O., Hansen, E. S., He, S., Kjærsgaard‐Andersen, P., & Bünger, C. E. (1991) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100090409 · Cited by 9 · see citing works
Flagged first, then by citations
1 of the 32 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Bone defect animal models for testing efficacy of bone substitute biomaterials
Li, Y., Chen, S.-K., Li, L., Qin, L., Wang, X., & Lai, Y. (2015) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2015.05.002 · Cited by 432 · see citing works
Self-Assembled Proteins and Peptides for Regenerative Medicine
Hosseinkhani, H., Hong, P., & Yü, D. (2013) · Chemical Reviews · doi:10.1021/cr300131h · Cited by 324 · see citing works
Fracture healing in the elderly patient
Gruber, R., Koch, H., Doll, B. A., Tegtmeier, F. T., Einhorn, T. A., & Hollinger, J. O. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.09.008 · Cited by 284 · see citing works
Morgan, E. F., Mason, Z. D., Chien, K. B., Pfeiffer, A. J., Barnes, G. B., Einhorn, T. A., & Gerstenfeld, L. C. (2008) · Bone · doi:10.1016/j.bone.2008.10.039 · Cited by 267 · see citing works
Growth factor delivery: How surface interactions modulate release in vitro and in vivo
King, W. J., & Krebsbach, P. H. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.03.004 · Cited by 192 · see citing works
Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence
Saul, D., & Khosla, S. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac008 · Cited by 185 · see citing works
The effect of fluoride contents in fluoridated hydroxyapatite on osteoblast behavior
Qu, H., & Wei, M. (2005) · Acta Biomaterialia · doi:10.1016/j.actbio.2005.09.003 · Cited by 168 · see citing works
Nicola, R. A., Jorgetti, V., Rigau, J., Pacheco, M. T. T., dos Reis, L. M., & Zângaro, R. A. (2003) · Lasers in Medical Science · doi:10.1007/s10103-003-0260-z · Cited by 153 · see citing works
Modulating osteogenesis of mesenchymal stem cells by modifying growth factor availability
Huang, Z., Ren, P., Ma, T., Smith, R. L., & Goodman, S. B. (2010) · Cytokine · doi:10.1016/j.cyto.2010.06.002 · Cited by 138 · see citing works
Growth Factor Interactions in Bone Regeneration
Kempen, D. H. R., Creemers, L. B., Alblas, J., Lu, L., Verbout, A. J., Yaszemski, M. J., & Dhert, W. J. A. (2010) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2010.0176 · Cited by 124 · see citing works
Elevated transforming growth factor-beta 1 (TGF-β1) levels in human fracture healing
Sarahrudi, K., Thomas, A., Mousavi, M., Kaiser, G., Starlinger, J., Kecht, M., Hajdú, Š., & Aharinejad, S. (2011) · Injury · doi:10.1016/j.injury.2011.03.055 · Cited by 120 · see citing works
Bastian, O. W., Koenderman, L., Alblas, J., Leenen, L. P. H., & Blokhuis, T. J. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.02.001 · Cited by 119 · see citing works
Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice
Liu, J., Zhang, J., Lin, X., Boyce, B. F., Zhang, H., & Xing, L. (2022) · Journal of Clinical Investigation · doi:10.1172/jci148073 · Cited by 112 · see citing works
Wenk, E., Meinel, A. J., Wildy, S., Merkle, H. P., & Meinel, L. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.073 · Cited by 112 · see citing works
Bone ingrowth in bFGF-coated hydroxyapatite ceramic implants
Schnettler, R., Alt, V., Dingeldein, E., Pfefferle, H.-J., Kilián, O., Meyer, C., Heiß, C., & Wenisch, S. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00354-5 · Cited by 89 · see citing works
The role of anabolic hormones for wound healing in catabolic states.
Demling, R. H. (2005) · PubMed · Cited by 81 · see citing works
Schmidmaier, G., Wildemann, B., Ostapowicz, D., Kandziora, F., Stange, R., Haas, N., & Raschke, M. C. E. J. (2003) · Journal of Orthopaedic Research® · doi:10.1016/j.orthres.2003.09.009 · Cited by 78 · see citing works
Sheng, R., Cao, M., Song, M., Wang, M., Zhang, Y., Shi, L., Xie, T., Li, Y., Wang, J., & Rui, Y. (2023) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2023.09.007 · Cited by 74 · see citing works
Delivery of Growth Factors Using Gene Therapy to Enhance Bone Healing
Southwood, L. L., Frisbie, D. D., Kawcak, C. E., & McIlwraith, C. W. (2004) · Veterinary Surgery · doi:10.1111/j.1532-950x.2004.04080.x · Cited by 69 · see citing works
Xue, P., Wu, X., Zhou, L., Ma, H., Wang, Y., Liu, Y., Ma, J., & Li, Y. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.02.088 · Cited by 65 · see citing works
Calcium Phosphate-Based Bone Substitutes
Schnettler, R., Stahl, J.-P., Alt, V., Pavlidis, T., Dingeldein, E., & Wenisch, S. (2004) · European Journal of Trauma · doi:10.1007/s00068-004-1393-x · Cited by 65 · see citing works
Subaie, A. E. A., Emami, E., Tamimi, I., Laurenti, M., Eimar, H. A., Abdallah, M., & Tamimi, F. (2016) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12506 · Cited by 64 · see citing works
Bone marrow stem cells and biological scaffold for bone repair in aging and disease
Srouji, S., & Livne, E. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.031 · Cited by 62 · see citing works
Self-citationChondrocyte-derived transglutaminase promotes maturation of preosteoblasts in periosteal bone
Nurminskaya, M., Magee, C., Faverman, L., & Linsenmayer, T. F. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00445-7 · Cited by 62 · see citing works
Aspera-Werz, R. H., Chen, T., Ehnert, S., Zhu, S., Fröhlich, T., & Nussler, A. K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122915 · Cited by 58 · see citing works
Kenswil, K. J. G., Jaramillo, A. C., Ping, Z., Chen, S., Hoogenboezem, R. M., Mylona, M., Adisty, M. N., Bindels, E. M. J., Bos, P. K., Stoop, H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.070 · Cited by 54 · see citing works
Local delivery of growth factors from coated titanium plates increases osteotomy healing in rats
Wildemann, B., Bamdad, P., Holmer, C., Haas, N. P., Raschke, M., & Schmidmaier, G. (2004) · Bone · doi:10.1016/j.bone.2004.01.015 · Cited by 53 · see citing works
Son, S., Sarkar, S. K., Linh, N. T. B., Padalhin, A., Kim, B. R., Jung, H. I., & Lee, B. (2014) · Journal of Biomaterials Applications · doi:10.1177/0885328214551373 · Cited by 47 · see citing works
3D Scaffolds for Bone Marrow Stem Cell Support in Bone Repair
Srouji, S., Kizhner, T. A., & Livne, E. (2006) · Regenerative Medicine · doi:10.2217/17460751.1.4.519 · Cited by 46 · see citing works
Self-citationRecombinant human BMP‐7 effectively prevents non‐union in both young and old rats
Hak, D. J., Makino, T., Niikura, T., Hazelwood, S. J., Curtiss, S. B., & Reddi, A. H. (2005) · Journal of Orthopaedic Research® · doi:10.1002/jor.20022 · Cited by 45 · see citing works
Dose response of bone mass to dietary arachidonic acid in piglets fed cow milk-based formula
Blanaru, J. L., Kohut, J., Fitzpatrick-Wong, S. C., & Weiler, H. A. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.1.139 · Cited by 45 · see citing works
A review: In vivo studies of bioceramics as bone substitute materials
Al‐allaq, A. A., & Kashan, J. S. (2022) · Nano Select · doi:10.1002/nano.202200222 · Cited by 35 · see citing works
Zhao, S., Qiao, Z., Pfeifer, R., Pape, H.-C., Mao, K., Tang, H., Meng, B., Chen, S., & Liu, H. (2024) · European Journal of Medical Research · doi:10.1186/s40001-023-01604-7 · Cited by 35 · see citing works
“Scholars have reported that TGF-β contributes to treating bone defects in rats [93].”
Wu, L., Zhang, G., Guo, C., & Pan, Y. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.04.048 · Cited by 33 · see citing works
Zaky, A. A., Elshenawy, H. M., Harhash, T. A. H., Shalash, M., & Awad, N. I. (2016) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2016.140 · Cited by 32 · see citing works
Dual Delivery of BMP2 and IGF1 Through Injectable Hydrogel Promotes Cranial Bone Defect Healing
Park, Y., Lin, S., Bai, Y., Moeinzadeh, S., Kim, S., Huang, J., Lee, U., Huang, N. F., & Yang, Y. (2022) · Tissue Engineering Part A · doi:10.1089/ten.tea.2022.0002 · Cited by 30 · see citing works
Aging Does Not Lessen the Effectiveness of TGFβ2-Enhanced Bone Regeneration
Sumner, D. R., Tm, T., Cohen, M. S., Losavio, P. S., Urban, R., Nichols, E. H., & McPherson, J. M. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.4.730 · Cited by 29 · see citing works
Hara, Y., Ghazizadeh, M., Shimizu, H., Matsumoto, H., Saito, N., Yagi, T., Mashiko, K., Mashiko, K., Kawai, M., & Yokota, H. (2017) · Journal of Nippon Medical School · doi:10.1272/jnms.84.12 · Cited by 24 · see citing works
Microscopy analysis of bone marrow–derived osteoprogenitor cells cultured on hydrogel 3‐D scaffold
Srouji, S., Maurice, S., & Livne, E. (2005) · Microscopy Research and Technique · doi:10.1002/jemt.20144 · Cited by 24 · see citing works
Self-citationThe osteogenic potential of human bone callus
Han, W., He, W., Yang, W., Li, J., Yang, Z., Lu, X., Qin, A., & Qian, Y. (2016) · Scientific Reports · doi:10.1038/srep36330 · Cited by 23 · see citing works
Cei, S., Kandler, B., Fügl, A., Gabriele, M., Hollinger, J. O., Watzek, G., & Gruber, R. (2006) · Journal of Periodontology · doi:10.1902/jop.2006.050155 · Cited by 23 · see citing works
Zhang, H., Aronow, M. S., & Gronowicz, G. (2005) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30400 · Cited by 22 · see citing works
Konka, J., Español, M., Bosch, B. M., de Oliveira, E., & Ginebra, M. (2021) · Materials Today Bio · doi:10.1016/j.mtbio.2021.100137 · Cited by 19 · see citing works
Managing Atrophic Nonunion in the Geriatric Population
Hobby, B. D., & Lee, M. A. (2013) · Orthopedic Clinics of North America · doi:10.1016/j.ocl.2013.01.011 · Cited by 18 · see citing works
Zhang, R., Jo, J., Kanda, R., Nishiura, A., Hashimoto, Y., & Matsumoto, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612741 · Cited by 17 · see citing works
Biological Functions of Let-7e-5p in Promoting the Differentiation of MC3T3-E1 Cells
Wang, C., Liu, S., Li, J., Cheng, Y., Wang, Z., Feng, T., Lu, G., Wang, S., Song, J., Xia, P., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.671170 · Cited by 14 · see citing works
Ben‐David, D., Livne, E., & Reznick, A. Z. (2012) · Inflammation Research · doi:10.1007/s00011-012-0461-7 · Cited by 14 · see citing works
Self-citationBiotherapeutics in Orthopaedic Medicine
Puleo, D. A. (2003) · BioDrugs · doi:10.2165/00063030-200317050-00001 · Cited by 13 · see citing works
Lehner, B., Bauer, J. S., Rödel, F., Grabenbauer, G. G., Neukam, F. W., & Schultze–Mosgau, S. (2004) · International Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.ijom.2003.10.009 · Cited by 12 · see citing works
Elimelech, R., Khoury, N., Tamari, T., Blumenfeld, I., Gutmacher, Z., & Zigdon‐Giladi, H. (2019) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.12775 · Cited by 12 · see citing works
Self-citationShojaee, A., Parham, A., Ejeian, F., & Nasr‐Esfahani, M. H. (2019) · Research in Veterinary Science · doi:10.1016/j.rvsc.2019.06.015 · Cited by 10 · see citing works
Xu, J.-C., Wu, G., Liu, H.-L., Liu, J., Yan, X., & Chen, J.-T. (2010) · Saudi Medical Journal · doi:10.15537/1658-3175.5046 · Cited by 9 · see citing works
TGF-beta1 Exposure from Bone Surfaces by Chemical Treatment Modalities
Smith, E. L., Colombo, J., Sloan, A. J., & Waddington, R. (2011) · European Cells and Materials · doi:10.22203/ecm.v021a15 · Cited by 8 · see citing works
Review of State of the Art: Growth Factor-Based Systems for Use as Bone Graft Substitutes
Arora, A., Bhattacharjee, A., & Katti, D. S. (2014) · ASTM International eBooks · doi:10.1520/mono62013002707 · Cited by 7 · see citing works
Beger, B., Blatt, S., Pabst, A. M., Hansen, T., Goetz, H., Al‐Nawas, B., & Ziebart, T. (2018) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2018.06.002 · Cited by 6 · see citing works
Azgın, İ., Arbağ, H., Eryılmaz, M. A., & Çelik, Z. E. (2020) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2020.01.013 · Cited by 6 · see citing works
Growth factor release in extra- and intramedullary osteosynthesis following tibial fracture
Sarahrudi, K., Thomas, A., Heinz, T., Krumboeck, A., Vécsei, V., & Aharinejad, S. (2010) · Injury · doi:10.1016/j.injury.2010.11.021 · Cited by 6 · see citing works
Akhil, K., Pramashivaiah, R., Prabhuji, M. L. V., Tasleem, R., Almubarak, H. M., Bahamdan, G. K., Luke, A. M., Shetty, K. P., Snigdha, N. T., & Bhavikatti, S. K. (2023) · Medicina · doi:10.3390/medicina59061178 · Cited by 4 · see citing works
Damerau, A., Buttgereit, F., & Gaber, T. (2022) · Processes · doi:10.3390/pr10030550 · Cited by 5 · see citing works
Craniofacial Tissue Engineering
Marra, K. G., Mooney, M. P., & Hollinger, J. O. (2016) · Taylor & Francis eBooks · doi:10.1081/e-ebpp-120052212 · Cited by 4 · see citing works
Bhadane, B. K. (2018) · Journal of Stem Cell Research & Therapeutics · doi:10.15406/jsrt.2018.04.00117 · Cited by 3 · see citing works
Biogerontology research in Israel
Globerson, A. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00207-2 · Cited by 3 · see citing works
Cell instructive silk fibroin scaffolds for tissue engineering
Meinel, A. J. (2010) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-a-006325663 · Cited by 3 · see citing works
Nanotechnology in Tissue Engineering
Hosseinkhani, H. (2019) · Wiley eBooks · doi:10.1002/9783527818921.ch8 · Cited by 3 · see citing works
Biogerontology research in Israel
Globerson, A., & Reznick, A. Z. (2010) · Biogerontology · doi:10.1007/s10522-010-9277-4 · Cited by 2 · see citing works
Hosseinkhani, H. (2022) · doi:10.1002/9783527826674.ch8 · Cited by 2 · see citing works
Livne, E., & Srouji, S. (2012) · Springer eBooks · doi:10.1007/978-1-4614-2059-0_8 · Cited by 1 · see citing works
Self-citationSchnettler, R., Alt, V., Stahl, J. P., & Wenisch, S. (2006) · Springer eBooks · doi:10.1007/3-540-32345-7_2
Hamdi, H., El-Ghareeb, A.-W., Shamakh, A., & Saeed, S. (2011)
[Clinical and experimental studies of osteogenesis in dogs].
Theyse, L. F. H. (2007) · PubMed
Tissue Engineering of Craniofacial Structure
Hollinger, J. O., Marra, K. G., & Mooney, M. P. (2005) · CRC Press eBooks · doi:10.1201/9781420027563.ch30
Abd-Allah, M., Farid, M., Korany, N. S., & Adawy, H. (2016) · Al-Azhar Dental Journal for Girls · doi:10.21608/adjg.2016.5186
Anti-Aging Medicine LiteratureWatch
(2002) · Rejuvenation Research · doi:10.1089/109454502321091509
Perry, A., Kim, C. W., & Garfin, S. R. (2008) · Elsevier eBooks · doi:10.1016/b978-0-7216-2872-1.50107-2
Oviawe, E. I., Fadasan, S. T., Lawal, M., Suleiman, M. H., & Bada, A. A. (2023) · Farm Animal Health and Nutrition · doi:10.58803/fahn.v2i2.17
Konka, J. (2021) · doi:10.5821/dissertation-2117-420264
- Authors
- Blumenfeld, I., Srouji, S., Lanir, Y., Laufer, D., & Livne, E.
- Affiliations
- Rambam Health Care Campus (IL)
- Technion – Israel Institute of Technology (IL)
- Corresponding author
- Livne, E.
- ORCID
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 37
- Issue
- 4
- Pages
- 553-565
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2072531220
- Cited by
- 77
- References
- 32
- Citations by year
- 2024: 1 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 7 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
- Keywords
- bone defect repair, aging, TGF-beta, insulin-like growth factor I, femoral defect, bone mineralization, bone bridge formation, trabecular bone, bone mechanical properties, growth factors, aged rats
- MeSH terms
- Aging, Animals, Biomechanical Phenomena, Female, Insulin-Like Growth Factor I, Stress, Mechanical, Transforming Growth Factor beta, Bone Remodeling, Fracture Healing, Rats, Wistar, Rats
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