Heterotrophic production of eicosapentaenoic acid by microalgae
Abstract
Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid that plays an important role in the regulation of biological functions and prevention and treatment of a number of human diseases such as heart and inflammatory diseases. As fish oil fails to meet the increasing demand for purified EPA, alternative sources are being sought. Microalgae contain large quantities of high-quality EPA and they are considered a potential source of this important fatty acid. Some microalgae can be grown heterotrophically on cheap organic substrate without light. This mode of cultivation can be well controlled and provides the possibility to maximize EPA production on a large scale. Numerous strategies have been investigated for commercial production of EPA by microalgae. These include screening of high EPA-yielding microalgal strains, improvement of strains by genetic manipulation, optimization of culture conditions, and development of efficient cultivation systems. This paper reviews recent advances in heterotrophic production of EPA by microalgae with an emphasis on the use of diatoms as producing organisms.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Algae growth and production of Omega-3 polyunsaturated fatty acids is greatly influenced by carbon sources and light strength.
“The algae growth and productions of Omega-3 Polyunsaturated fatty acids is greatly influence by carbon sources and light strength [201–203].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [201]
The citation lists haven’t been fetched yet
References 101 · Cited by 372
- Authors
- Wen, Z.-Y., & Chen, F.
- Affiliations
- University of Hong Kong (HK)
- Corresponding author
- Chen, Feng
- ORCID
- Chen, Feng
- Venue
- Biotechnology Advances
- Publisher
- Elsevier BV
- Published
- 2003-07
- Volume
- 21
- Issue
- 4
- Pages
- 273-294
- ISSN
- 0734-9750 (ISSN-L)
- OpenAlex
- W1983223846
- Cited by
- 372
- References
- 101
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 6 · 2023: 8 · 2022: 16 · 2021: 20 · 2020: 25 · 2019: 19 · 2018: 13 · 2017: 29 · 2016: 22 · 2015: 34 · 2014: 17 · 2013: 26 · 2012: 22
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biotechnology Advances (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- eicosapentaenoic acid, heterotrophic cultivation, microalgae, diatoms, omega-3 polyunsaturated fatty acids, EPA production, strain screening, genetic engineering, culture condition optimization, cropping systems
- MeSH terms
- Carbon, Cells, Cultured, Fatty Acids, Unsaturated, Genetic Engineering, Light, Nitrogen, Photosynthesis, Quality Control, Eicosapentaenoic Acid, Diatoms, Cell Culture Techniques, Bioreactors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
