Bradykinin stimulates the release of tissue plasminogen activator in human coronary circulation: effects of angiotensin-converting enzyme inhibitors
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Objectives The goal of this study was to determine: 1) whether bradykinin (BK) directly stimulates tissue plasminogen activator (tPA) secretion in human coronary circulation, and 2) whether angiotensin-converting enzyme (ACE) inhibition favorably alters the fibrinolytic balance regulated by BK.Background Bradykinin is a potent stimulator of tPA secretion in endothelial cells; however, the effect of BK on tPA release in the human coronary circulation has not been studied.Methods Fifty-six patients with atypical chest pain were randomly assigned to two groups: 25 patients were treated with the ACE inhibitor enalapril (ACE inhibitor group), and 31 were not treated with ACE inhibitors (non-ACE inhibitor group). Graded doses of BK (0.2, 0.6, 2.0 microg/min), acetylcholine (ACh) (30 microg/min) and papaverine (PA) (12 mg) were administered into the left coronary artery. Coronary blood flow (CBF) was evaluated by Doppler flow velocity measurement. Blood samples were taken from the aorta (Ao) and the coronary sinus (CS).Results Bradykinin induced similar increases in CBF in both groups. The net tPA release induced by BK was dose-dependently increased in both groups, and the extent of that increase in the ACE inhibitor group was greater than that in the non-ACE inhibitor group. Bradykinin did not alter plasminogen activator inhibitor-1 (PAI-1) levels in the Ao or CS in either group. Neither ACh nor PA altered tPA levels or PAI-1 levels in either group.Conclusions Intracoronary infusion of BK stimulates tPA release without causing any change in PAI-1 levels in the human coronary circulation. In addition, this effect of BK is augmented by an ACE inhibitor.
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Stimulated t-PA release in the human forearm vasculature correlates with t-PA release in the coronary vasculature.
“Stimulated t-PA release in the human forearm vasculature correlates with t-PA release in the coronary vasculature”
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Diminished forearm endothelial t-PA release is associated with an increased risk of cardiovascular events.
“diminished forearm endothelial t-PA release is associated with an increased risk of cardiovascular events.”
From The Vasculature in Prediabetes (2018) · cites this paper as [128]
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Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911 · see citing works
PLASMINOGEN ACTIVATOR INHIBITOR IN PLASMA: RISK FACTOR FOR RECURRENT MYOCARDIAL INFARCTION
Hamsten, A., Walldius, G., Szamosi, A., Blombäck, M., de Faire, U., Dahlén, G. H., Landou, C., & Wiman, B. (1987) · The Lancet · doi:10.1016/s0140-6736(87)93050-9 · Cited by 1,474 · see citing works
Mancini, G. B. J., Henry, G. C., Macaya, C., O’Neill, B. J., Pucillo, A. L., Carere, R. G., Wargovich, T. J., Mudra, H. G., Lüscher, T. F., Klibaner, M. I., et al. (1996) · Circulation · doi:10.1161/01.cir.94.3.258 · Cited by 1,056 · see citing works
Validation of a Doppler guide wire for intravascular measurement of coronary artery flow velocity.
Doucette, J. W., Corl, P. D., Payne, H. M., Flynn, A. E., Goto, M., Nassí, M., & Segal, J. (1992) · Circulation · doi:10.1161/01.cir.85.5.1899 · Cited by 1,017 · see citing works
Yusuf, S., Pepine, C. J., Garces, C., Pouleur, H. G., Rousseau, M. F., Salem, D. N., Kostis, J. B., Benedict, C. R., Bourassa, M. G., & Pitt, B. (1992) · The Lancet · doi:10.1016/0140-6736(92)92889-n · Cited by 665 · see citing works
Thögersen, A. M., Jansson, J.-H., Boman, K., Nilsson, T. K., Weinehall, L., Huhtasaari, F., & Hallmans, G. (1998) · Circulation · doi:10.1161/01.cir.98.21.2241 · Cited by 602 · see citing works
Endogenous tissue-type plasminogen activator and risk of myocardial infarction
Ridker, P. M., Vaughan, D. E., Manson, J., Hennekens, C. H., & Stampfer, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)90998-v · Cited by 580 · see citing works
Ridker, P. M., Gaboury, C. L., Conlin, P. R., Seely, E. W., Williams, G. H., & Vaughan, D. E. (1993) · Circulation · doi:10.1161/01.cir.87.6.1969 · Cited by 400 · see citing works
Endothelial Dysfunction, Impaired Endogenous Fibrinolysis, and Cigarette Smoking
Newby, D. E., Wright, R. A., Labinjoh, C., Ludlam, C. A., Fox, K. A. A., Boon, N. A., & Webb, D. J. (1999) · Circulation · doi:10.1161/01.cir.99.11.1411 · Cited by 379 · see citing works
Gebara, O., Mittleman, M. A., Sutherland, P. A., Lipinska, I., Matheney, T. H., Xu, P., Welty, F. K., Wilson, P. W. F., Levy, D. A., Muller, J. E., et al. (1995) · Circulation · doi:10.1161/01.cir.91.7.1952 · Cited by 298 · see citing works
Vaughan, D. E., Rouleau, J. L., Ridker, P. M., Arnold, J. M. O., Menapace, F. J., & Pfeffer, M. A. (1997) · Circulation · doi:10.1161/01.cir.96.2.442 · Cited by 264 · see citing works
Jansson, J.-H., Olofsson, B. O., & Nilsson, T. (1993) · Circulation · doi:10.1161/01.cir.88.5.2030 · Cited by 241 · see citing works
Endothelium-dependent hyperpolarization caused by bradykinin in human coronary arteries.
Nakashima, M., Mombouli, J., Taylor, A. A., & Vanhoutte, P. M. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116907 · Cited by 230 · see citing works
Coronary flow velocity dynamics in normal and diseased arteries
Ofili, E., Labovitz, A. J., & Kern, M. J. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)90128-y · Cited by 200 · see citing works
An Endothelial Storage Granule for Tissue-Type Plasminogen Activator
EMEIS, J. J., Schrauwen, Y., van den Hoogen, C. M., de Priester, W., Westmuckett, A. D., & Lupu, F. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.1.245 · Cited by 158 · see citing works
Bradykinin Stimulates Tissue Plasminogen Activator Release in Human Vasculature
Brown, N. J., Gainer, J. V., Stein, C., & Vaughan, D. E. (1999) · Hypertension · doi:10.1161/01.hyp.33.6.1431 · Cited by 152 · see citing works
Selective Stimulation of Tissue-Type Plasminogen Activator (t-PA) In Vivo by Infusion of Bradykinin
Brown, N. J., Nadeau, J., & Vaughan, D. E. (1997) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1656000 · Cited by 145 · see citing works
Wright, R. A., Flapan, A. D., Alberti, K. G. M. M., Ludlam, C. A., & Fox, K. A. A. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90543-6 · Cited by 139 · see citing works
Schrauwen, Y., Kooistra, T., de Vries, R., & Emeis, J. J. (1995) · Blood · doi:10.1182/blood.v85.12.3510.bloodjournal85123510 · Cited by 135 · see citing works
Maiello, M., Boeri, D., Podestà, F., Cagliero, E., Vichi, M., Odetti, P. R., Adezati, L., & Lorenzi, M. (1992) · Diabetes · doi:10.2337/diab.41.8.1009 · Cited by 93 · see citing works
Hemodynamic forces modulate the effects of cytokines on fibrinolytic activity of endothelial cells
Kawai, Y., Matsumoto, Y., Watanabe, K., Yamamoto, H., Satoh, K., Murata, M., Handa, M., & Ikeda, Y. (1996) · Blood · doi:10.1182/blood.v87.6.2314.bloodjournal8762314 · Cited by 89 · see citing works
Stein, C. M., Brown, N. L., Vaughan, D. E., Lang, C. C., & Wood, A. J. J. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00210-1 · Cited by 85 · see citing works
Kuga, T., Mohri, M., Egashira, K., Hirakawa, Y., Tagawa, T., Shimokawa, H., & Takeshita, A. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00112-5 · Cited by 83 · see citing works
Pandolfi, A., Iacoviello, L., Capani, F., Vitacolonna, E., Donati, M. B., & Consoli, A. (1996) · Diabetologia · doi:10.1007/s001250050594 · Cited by 76 · see citing works
Prasad, A., Husain, S., & Quyyumi, A. A. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00611-1 · Cited by 63 · see citing works
Toda, N., & Okamura, T. (1989) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1989.257.3.h988 · Cited by 62 · see citing works
Beneficial Effects of Bradykinin on Myocardial Energy Metabolism and Infarct Size
Linz, W., Wiemer, G., & Schölkens, B. A. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00466-9 · Cited by 58 · see citing works
Fibrinolytic actions of intra-arterial angiotensin II and bradykinin in vivo in man
Labinjoh, C. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00126-7 · Cited by 41 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Jansson JH, Olofsson BO, Nilsson TK. Predictive value of tissue plasminogen activator mass concentration on long-term mortality in patients with coronary artery disease. Circulation 1993;88:2030 -4.
- Pfeffer MA, Braunwald E, Moye LA, et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 1992;327:669 -77.
- Ridker PM, Gaboury CL, Conlin PR, Seely EW, Williams GH, Vaughan DE. Stimulation of plasminogen activator inhibitor in vivo by infusion of angiotensin II. Circulation 1993;87:1969 -73.
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Matsuo, S., Matsumoto, T., Takashima, H., Ohira, N., Yamane, T., Yasuda, Y., Tarutani, Y., & Horie, M. (2004) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200408000-00004 · Cited by 37 · see citing works
Self-citationMatsumoto, T., Minai, K., Horie, H., Ohira, N., Takashima, H., Tarutani, Y., Yasuda, Y., Ozawa, T., Matsuo, S., Kinoshita, M., et al. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00162-1 · Cited by 37 · see citing works
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Fogari, R., Zoppi, A., Mugellini, A., Maffioli, P., Lazzari, P., & Derosa, G. (2011) · Hypertension Research · doi:10.1038/hr.2011.137 · Cited by 26 · see citing works
Malinowska-Zaprzałka, M., Wojewódzka‐Żeleźniakowicz, M., Dryl, D., Grabowska, S. Z., & Chabielska, E. (2005) · PubMed · Cited by 24 · see citing works
Borghi, C., & Francesca, S. (2012) · Patient Preference and Adherence · doi:10.2147/ppa.s23232 · Cited by 21 · see citing works
Pretorius, M., Luther, J. M., Murphey, L. J., Vaughan, D. E., & Brown, N. J. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000186185.13977.94 · Cited by 21 · see citing works
Culy, C. R., & Jarvis, B. (2002) · Drugs · doi:10.2165/00003495-200262020-00009 · Cited by 20 · see citing works
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Borghi, C., & Cicero, A. F. G. (2010) · Clinical Drug Investigation · doi:10.1007/bf03256912 · Cited by 19 · see citing works
Rockson, S. G., deGoma, E. M., & Fonarow, G. C. (2007) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-007-6043-1 · Cited by 18 · see citing works
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Cruden, N. L. M., & Newby, D. E. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.05.038 · Cited by 15 · see citing works
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&NA; (2011) · Clinical Drug Investigation · doi:10.2165/11533610-000000000-00000 · Cited by 13 · see citing works
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Bentley, J. P., Asselbergs, F. W., Coffey, C. S., Hebert, P. R., Moore, J. H., Hillege, H. L., & van Gilst, W. H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012757 · Cited by 12 · see citing works
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Furon, J., Yetim, M., Pouettre, E., de Lizarrondo, S. M., Maubert, E., Hommet, Y., Lebouvier, L., Zheng, Z., Ali, C., & Vivien, D. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00411-w · Cited by 10 · see citing works
Takashima, H., Matsumoto, T., Nakae, I., Yamane, T., & Horie, M. (2007) · Thrombosis Research · doi:10.1016/j.thromres.2006.10.024 · Cited by 8 · see citing works
Self-citationEndothelial function in patients with chest pain and normal coronary angiograms.
Grąbczewska, Z., Thews, M., Góralczyk, K., & Kubica, J. (2007) · PubMed · Cited by 8 · see citing works
The Role of Renin Angiotensin System Intervention in Stage B Heart Failure
Collier, P. H., & McDonald, K. (2011) · Heart Failure Clinics · doi:10.1016/j.hfc.2011.11.006 · Cited by 7 · see citing works
Bradykinin for the Treatment of Cardiovascular Disease
Palkhiwala, S. A., Frishman, W. H., & Warshafsky, S. (2001) · Heart Disease · doi:10.1097/00132580-200109000-00010 · Cited by 7 · see citing works
Matsumoto, T., Takashima, H., Nakae, I., Yamane, T., Hayashi, H., & Horie, M. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.154278 · Cited by 5 · see citing works
Self-citationRosendorff, C., Lackland, D. T., Allison, M., Aronow, W. S., Black, H. R., Blumenthal, R. S., Cannon, C. P., de Lemos, J. A., Elliott, W. J., Findeiss, L., et al. (2015) · Cited by 5 · see citing works
Evidence of a net release of tissue-type plasminogen activator across the human cerebral vasculature
Blomstrand, C., Westerlind, A., & Jern, C. (2004) · Thrombosis and Haemostasis · doi:10.1160/th03-11-0693 · Cited by 5 · see citing works
Yoshino, T., Nakae, I., Matsumoto, T., Mitsunami, K., & Horie, M. (2010) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2010.05455.x · Cited by 4 · see citing works
Self-citationIn vivo release of tissue-type plasminogen activator antigen from the human brachial artery
Dovjak, N., Blinc, A., & Keber, D. (2002) · Thrombosis Research · doi:10.1016/s0049-3848(02)00132-9 · Cited by 4 · see citing works
Eriksen, M., Ilebekk, A., Cataliotti, A., Carlson, C. R., Lyberg, T., & Aspelin, T. (2014) · Thrombosis and Haemostasis · doi:10.1160/th14-01-0059 · Cited by 4 · see citing works
Reactive hyperemia and tissue-type plasminogen activator release in hypertensive men
Dell’Omo, G., Negri, F. D., Carmassi, F., Ruocco, L. A., Mariani, M., & Pedrinelli, R. (2003) · Blood Coagulation & Fibrinolysis · doi:10.1097/00001721-200301000-00005 · Cited by 5 · see citing works
Joffe, S., & Phillips, R. A. (2013) · Current Heart Failure Reports · doi:10.1007/s11897-013-0137-9 · Cited by 2 · see citing works
Wojewódzka‐Żeleźniakowicz, M., Stankiewicz, A., Malinowska-Zaprzałka, M., & Chabielska, E. (2005) · PubMed · Cited by 2 · see citing works
Cardiovascular Disease and Insulin Resistance
Ajjan, R., & Grant, P. J. (2007) · Springer eBooks · doi:10.1007/978-1-84628-715-2_138 · Cited by 2 · see citing works
Tailoring the management of hypertension to comorbidities
Mendoza, M. F., Kachur, S. M., & Lavie, C. J. (2021) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000860 · Cited by 1 · see citing works
Österlund, B. (2002) · Cited by 1 · see citing works
Ulfhammer, E. (2007) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Carrillo-Jimenez, R., Hennekens, C. H., & Lamas, G. A. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-351-4_14
Is Angiotensin Receptor Blockade Antithrombotic?
Lim, H. S., & Lip, G. Y. H. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.22.2790-a
Pharmakotherapie des Renin-Angiotensin- Aldosteron-Systems
Allgeier, J., & Hauf, G. F. (2004) · Springer eBooks · doi:10.1007/978-3-642-18649-3_47
Gilyarevskiy, S. R. (2013) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2013-9-6-664-671
QuinaprilUpdate of its Pharmacology and Therapeutic Use in Cardiovascular Disorders
Culy, C. R., & Jarvis, B. (2002)
Bledsoe, G., Chao, L., & Chao, J. (2016)
Kliger, C., Schwartzbard, A. Z., Fisher, E., & WEINTRAUB, H. S. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-1366-4.00011-1
Pramanik, P. (2020) · Indian Journal of Science and Technology · doi:10.17485/ijst/v13i30.969
Yetim, M., Furon, J., de Lizarrondo, S. M., Pouettre, E., Maubert, E., Hommet, Y., Lebouvier, L., Zheng, Z., Ali, C., & Vivien, D. (2022) · Research Square · doi:10.21203/rs.3.rs-1706689/v1
Emerging path promoting neovascularization in chronic ischemia
Eton, D. (2025) · JVS-Vascular Insights · doi:10.1016/j.jvsvi.2025.100190
Furon, J., Yetim, M., Pouettre, E., de Lizarrondo, S. M., Maubert, E., Hommet, Y., Lebouvier, L., Zheng, Z., Ali, C., & Vivien, D. (2024) · Figshare · doi:10.6084/m9.figshare.26566058
- Authors
- Minai, K., Matsumoto, T., Horie, H., Ohira, N., Takashima, H., Yokohama, H., & Kinoshita, M.
- Affiliations
- Shiga University of Medical Science (JP)
- Corresponding author
- Matsumoto, Tetsuya
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 37
- Issue
- 6
- Pages
- 1565-1570
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2021577809
- Cited by
- 86
- References
- 28
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- bradykinin, tissue plasminogen activator, ACE inhibitors, enalapril, coronary circulation, fibrinolysis, plasminogen activator inhibitor-1, coronary blood flow, endothelial cells, atypical chest pain
- MeSH terms
- Acetylcholine, Analysis of Variance, Angiotensin-Converting Enzyme Inhibitors, Blood Flow Velocity, Bradykinin, Chest Pain, Coronary Circulation, Drug Synergism, Enalapril, Female, Fibrinolysis, Cardiac Catheterization, Hemodynamics, Humans, Male, Middle Aged, Papaverine, Tissue Plasminogen Activator, Vasodilator Agents, Echocardiography, Doppler, Coronary Angiography, Myocardial Ischemia
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