The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Carotid sinus syndrome: a modifiable risk factor for nonaccidental falls in older adults (SAFE PACE)
Open accessAbstract
Objectives The aim of the study was to determine whether cardiac pacing reduces falls in older adults with cardioinhibitory carotid sinus hypersensitivity (CSH).Background Cardioinhibitory carotid sinus syndrome causes syncope, and symptoms respond to cardiac pacing. There is circumstantial evidence for an association between falls and the syndrome.Methods A randomized controlled trial was done of consecutive older patients (>50 years) attending an accident and emergency facility because of a non-accidental fall. Patients were randomized to dual-chamber pacemaker implant (paced patients) or standard treatment (controls). The primary outcome was the number of falls during one year of follow-up.Results One hundred seventy-five eligible patients (mean age 73 +/- 10 years; 60% women) were randomized to the trial: pacemaker 87; controls 88. Falls (without loss of consciousness) were reduced by two-thirds: controls reported 669 falls (mean 9.3; range 0 to 89), and paced patients 216 falls (mean 4.1; range 0 to 29). Thus, paced patients were significantly less likely to fall (odds ratio 0.42; 95% confidence interval: 0.23, 0.75) than were controls. Syncopal events were also reduced during the follow-up period, but there were much fewer syncopal events than falls-28 episodes in paced patients and 47 in controls. Injurious events were reduced by 70% (202 in controls compared to 61 in paced patients).Conclusions There is a strong association between non-accidental falls and cardioinhibitory CSH. These patients would not usually be referred for cardiovascular assessment. Carotid sinus hypersensitivity should be considered in all older adults who have non-accidental falls.
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“Orthostatic BP measurements, CSM, and tilt testing are well tolerated, even in the frail elderly with cognitive impairment. 96,396,397”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [396]
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Cites
Risk Factors for Falls among Elderly Persons Living in the Community
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Gregoratos, G., Cheitlin, M. D., Conill, A., Epstein, A. E., Fellows, C., Ferguson, T. B., Freedman, R. A., Hlatky, M. A., Naccarelli, G. V., Saksena, S. V., et al. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00024-2 · Cited by 632
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Interventions for preventing falls in older people living in the community
Gillespie, L. D., Robertson, M. C., Gillespie, W. J., Sherrington, C., Gates, S., Clemson, L., & Lamb, S. E. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007146.pub3 · Cited by 3,966
ACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities
Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Estes, N. A. M., Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.032 · Cited by 2,546
Developed in collaboration with, European Heart Rhythm Association (EHRA), Heart Failure Association (HFA), and Heart Rhythm Society (HRS), societies, E. B. T. F., European Society of Emergency Medicine (EuSEM), European Federation of Internal Medicine (EFIM), European Union Geriatric Medicine Society (EUGMS), American Geriatrics Society (AGS), European Neurological Society (ENS), et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp298 · Cited by 2,040
2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya, A., de Lange, F. J., Deharo, J.-C., Elliott, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martín, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy037 · Cited by 1,951
Panel on Prevention of Falls in Older Persons, A. G. S. A. B. G. S. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.03234.x · Cited by 1,817
Metadata
- Authors
- Kenny, R. A. M., Richardson, D. A., Steen, N., Bexton, R. S., Shaw, F. E., & Bond, J.
- Affiliations
- Royal Victoria Infirmary (GB)
- Newcastle University (GB)
- Freeman Hospital (GB)
- Corresponding author
- Kenny, Rose Anne M
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2001-11
- Volume
- 38
- Issue
- 5
- Pages
- 1491-1496
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2102093657
- Cited by
- 344
- References
- 29
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 6 · 2020: 10 · 2019: 8 · 2018: 15 · 2017: 16 · 2016: 6 · 2015: 7 · 2014: 12 · 2013: 16 · 2012: 18
- FWCI
- 14.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- carotid sinus syndrome, carotid sinus hypersensitivity, cardioinhibitory syncope, cardiac pacing, pacemaker implantation, falls in older adults, fall prevention, syncope
- MeSH terms
- Accidental Falls, Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Algorithms, Cardiac Pacing, Artificial, Decision Trees, Emergency Service, Hospital, Female, Follow-Up Studies, Humans, Male, Mass Screening, Pacemaker, Artificial, Recurrence, Referral and Consultation, Risk Factors, Syncope, Geriatric Assessment, Logistic Models, Treatment Outcome
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