Duchenne's cardiomyopathy in a canine model: electrocardiographic and echocardiographic studies
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Thirteen dogs affected with X-linked Duchenne's muscular dystrophy and 11 female carrier dogs were studied by electrocardiography (ECG) and echocardiography. Twelve of the affected dogs were studied as immature animals and followed at 1 to 6 month intervals until they were 7 to 46 months of age. Compared with control dogs, affected dogs had significantly increased (p less than 0.02) Q/R ratios in ECG leads II, III, aVF, CV6LL (V2) and CV6LU (V4). Carrier dogs had significantly increased (p less than 0.02) Q/R ratios in leads V2 and V4. The Q/R ratio increased in three of six dogs followed up from age 6 months to greater than 2 years. The PR intervals were significantly shorter (p less than 0.02) in affected dogs. Ventricular arrhythmias were identified in four of six mature affected dogs. Two-dimensional echocardiography revealed distinctive hyperechoic lesions in 12 of the 13 affected dogs and in 6 of the 11 carrier dogs. Hyperechoic lesions corresponded to calcified myocardium and surrounding dense connective tissue. This study establishes the dog affected with Duchenne's muscular dystrophy as an animal model of Duchenne's cardiomyopathy and demonstrates that the heart in carrier dogs is affected by the dystrophic process.
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The Golden Retriever Muscular Dystrophy line develops cardiomyopathy closely resembling affected humans and is considered to better represent cardiac involvement in human DMD than mouse mdx counterparts.
“One of these lines is the Golden Retriever Muscular Dystrophy (Cooper, et al., 1988) which develops cardiomyopathy with features that closely resemble those of affected humans (Moise, et al., 1991; Valentine, Cooper, de Lahunta, O'Quinn, & Blue, 1988; Valentine, Cummings, & Cooper, 1989) and is considered to better represent cardiac involvement in human DMD than their mouse mdx counterparts (Nakam”
From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Moise, et al., 1991
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- Authors
- Moise, N. S., Valentine, B. A., Brown, C. A., Erb, H. N., Beck, K. A., Cooper, B. J., & Gilmour, R. F.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 1991-03
- Volume
- 17
- Issue
- 3
- Pages
- 812-820
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2039230574
- Cited by
- 89
- References
- 64
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 9 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- Duchenne muscular dystrophy, Duchenne cardiomyopathy, canine model, X-linked muscular dystrophy, carrier dogs, electrocardiographic changes, PR interval, ventricular arrhythmias, myocardial calcification, hyperechoic lesions, echocardiographic findings, animal models
- MeSH terms
- Animals, Dogs, Echocardiography, Electrocardiography, Female, Heart Diseases, Cardiomegaly, Male, Muscular Dystrophy, Animal, Radiography
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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