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Treatment of 63 severely digitalis-toxic patients with digoxin-specific antibody fragments
Open accessAbstract
Sixty-three patients with life-threatening digitalis intoxication were treated with purified fragments of digoxin-specific antibodies (Fab) obtained from sheep. Twenty-eight patients developed toxicity as the result of digitalis ingestion in a suicide attempt, 5 ingested a large amount of digoxin accidentally and 30 developed toxicity in the course of treatment for underlying heart disease. The dosage of digoxin-specific Fab was calculated to be equimolar to the amount of cardiac glycoside in the patient's body. Digitalis toxicity was completely reversed in most cases, with onset of effect usually within 30 minutes of administration of Fab fragments. Unbound and, therefore, active digoxin serum concentrations decreased to undetectable levels within minutes after administration of the fragments. In all patients who had elevated serum potassium concentrations caused by massive digitalis toxicity, treatment with the Fab fragments reversed the hyperkalemia. There were no obvious adverse reactions to treatment. Potentially life-threatening digitalis intoxication can be rapidly and safely reversed by treatment with purified digoxin-specific Fab fragments.
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Research works printed but not linked: 23
- Butler, 1967, Digoxin-specific antibodies, Proc Natl Acad Sei USA, 57, 71, 10.1073/pnas.57.1.71 · doi:10.1073/pnas.57.1.71
- Smith, 1969, Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay, N Engl J Med, 281, 1212, 10.1056/NEJM196911272812203 · DOI · Paper page
- Schmidt, 1971, Reversal of digoxin toxicity with specific antibodies, J Clin Invest, 50, 1738, 10.1172/JCI106663 · doi:10.1172/jci106663
- Nisonoff, 1964, Enzymatic digestion of rabbit gamma globulin and antibody and chromatography of digestion products, Methods Med Res, 10, 131
- Smith, 1974, Discussion paper: use of antibodies in the study of the mechanism of action of digitalis, Ann NY Acad Sei, 242, 731, 10.1111/j.1749-6632.1974.tb19134.x · doi:10.1111/j.1749-6632.1974.tb19134.x
- Smith, 1979, Immunogenicity and kinetics of distribution and elimination of sheep digoxin-specific IgG and Fab fragments in the rabbit and baboon, Clin Exp Immunol, 36, 384
- Lloyd, 1978, Contrasting rates of reversal of digoxin toxicity by digoxin-specific IgG and Fab fragments, Circulation, 58, 280, 10.1161/01.CIR.58.2.280 · doi:10.1161/01.cir.58.2.280
- Ochs, 1978, Reversal of inotropic effects of digoxin by specific antibodies and their Fab fragments in the conscious dog, J Pharmacol Exp Ther, 207, 64, 10.1016/S0022-3565(25)31393-5 · doi:10.1016/s0022-3565(25)31393-5
- Gardner, 1973, Effects of digoxin-specific antibodies on accumulation and binding of digoxin by human erythrocytes, J Clin Invest, 52, 1820, 10.1172/JCI107364 · doi:10.1172/jci107364
- Curd, 1971, The isolation of digoxin-specific antibody and its use in reversing the effects of digoxin, Proc Natl Acad Sei USA, 68, 2401, 10.1073/pnas.68.10.2401 · doi:10.1073/pnas.68.10.2401
- Mandel, 1972, The electrophysiologic effects of low and high digoxin concentrations on isolated mammalian cardiac tissue: reversal by digoxin-specific antibody, J Clin Invest, 51, 1378, 10.1172/JCI106933 · doi:10.1172/jci106933
- Smith, 1976, Reversal of advanced digoxin intoxication with Fab fragments of digoxin-specific antibodies, N Engl J Med, 294, 797, 10.1056/NEJM197604082941501 · DOI · Paper page
- Smith, 1982, Treatment of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments: experience in 26 cases, N Engl J Med, 307, 1357, 10.1056/NEJM198211253072201 · DOI · Paper page
- Bismuth, 1973, Hyperkalemia in acute digitalis poisoning: prognostic significance and therapeutic implications, Clin Toxicol, 6, 153, 10.3109/15563657308990513 · doi:10.3109/15563657308990513
- Gibb, 1983, Plasma digoxin: assay anomalies in Fab-treated patients, BrJ Clin Pharmacol, 16, 445, 10.1111/j.1365-2125.1983.tb02194.x · doi:10.1111/j.1365-2125.1983.tb02194.x
- Hess, 1979, Treatment of a case of lanatoside C intoxication with digoxin-specific F(ab')2 antibody fragments, Am Heart J, 98, 767, 10.1016/0002-8703(79)90476-9 · doi:10.1016/0002-8703(79)90476-9
- Hess, 1979, Antibody treatment of digoxin intoxication in a patient with renal failure, Dtsch Med Wochenschr, 104, 1273, 10.1055/s-0028-1129083 · doi:10.1055/s-0028-1129083
- Hess, 1982, Suicidal digoxin poisoning: conventional treatment and antibody therapy, Klin Wochenschr, 60, 401, 10.1007/BF01735931 · doi:10.1007/bf01735931
- Bouffard, 1982, Digitoxin intoxication: treatment with antidigoxin antibody Fab fragments, Nouv Presse Med, 11, 2928
- Domart, 1982, Digitoxin toxicity: re-versability of ventricular fibrillation with antidigoxin antibody fab fragments, Nouv Presse Med, 11, 3827
- Hess, 1983, Digitoxin intoxication with severe thrombocytopenia: reversal by digoxin-specific antibodies, Eur J Clin Invest, 13, 159, 10.1111/j.1365-2362.1983.tb00081.x · DOI
- Ye, 1983, Using digoxin antibody as a specific treatment for severe digitalis intoxication, Chin J Cardiol, 11, 242
- Smolarz, 1984, Report on the treatment of 16 cases of severe glycoside poisoning with sheep antidigoxin fragments (Fab), Z Kardiol, 73, 113
Cited by
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Topjian, A. A., Raymond, T. T., Atkins, D., Chan, M., Duff, J. P., Joyner, B. L., Lasa, J. J., Lavonas, E. J., Levy, A., Mahgoub, M., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000901 · Cited by 1,258
Kusumoto, F. M., Schoenfeld, M. H., Barrett, C., Edgerton, J. R., Ellenbogen, K. A., Gold, M. R., Goldschlager, N. F., Hamilton, R. M., Joglar, J. A., Kim, R. J., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.10.044 · Cited by 1,008
Vanden Hoek, T. L., Morrison, L. J., Shuster, M., Donnino, M., Sinz, E., Lavonas, E. J., Jeejeebhoy, F. M., & Gabrielli, A. (2010) · Circulation · doi:10.1161/circulationaha.110.971069 · Cited by 720
Kusumoto, F. M., Schoenfeld, M. H., Barrett, C., Edgerton, J. R., Ellenbogen, K. A., Gold, M. R., Goldschlager, N. F., Hamilton, R. M., Joglar, J. A., Kim, R. J., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000628 · Cited by 603
Metadata
- Authors
- Wenger, T. L., Butler, V. P., Haber, E., & Smith, T. W.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 1985-05
- Volume
- 5
- Issue
- 5
- Pages
- 118A-123A
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W1994368147
- Cited by
- 173
- References
- 0
- FWCI
- 24.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 10303 d)
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- Wenger, T. L., Butler, V. P., Haber, E., & Smith, T. W. (1985). Treatment of 63 severely digitalis-toxic patients with digoxin-specific antibody fragments. Journal of the American College of Cardiology. https://doi.org/10.1016/s0735-1097(85)80471-x
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