The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Reversal of Advanced Digoxin Intoxication with Fab Fragments of Digoxin-Specific Antibodies
Abstract
Purified Fab fragments of ovine digoxin-specific antibodies reversed severe digoxin intoxication in a patient who had taken 22.5 mg of the drug with suicidal intent. Atrioventricular block with extreme bradycardia was temporarily managed by pacing, but progressive, intractable hyperkalemia (serum potassium of 8.7 meq per liter) with increasing pacing threshold and progressive intraventricular conduction delay was controlled only after infusion of 1100 mg of Fab. Sinus rhythm returned 10 minutes after completion of Fab infusion. Within five hours, the serum potassium concentration fell to 4.0 meq per liter. Free digoxin concentrations in serum fell sharply to undetectable levels, whereas total serum digoxin concentration concomitantly increased 12-fold. Renal excretion of digoxin bound to Fab was documented. Reversal of toxicity was not accompanied by hemodynamic instability, and antibodies to sheep Fab fragments were not detected in the patient's serum after treatment. Thus, purified digoxin-specific Fab fragments are capable of rapid reversal of advanced digoxin toxicity.
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Cites
Schwartz, A., Lindenmayer, G. E., & Allen, J. C. (1975) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06680-3 · Cited by 875
The serum proteins in multiple myelomatosis
Kekwick, R. A. (1940) · Biochemical Journal · doi:10.1042/bj0341248 · Cited by 676
Determination of Therapeutic and Toxic Serum Digoxin Concentrations by Radioimmunoassay
Smith, T. W., Butler, V. P., & Haber, E. (1969) · New England Journal of Medicine · doi:10.1056/nejm196911272812203 · Cited by 583
Self-citationDigoxin intoxication: the relationship of clinical presentation to serum digoxin concentration
Smith, T. W., & Haber, E. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106457 · Cited by 336
Self-citationCharacterization of antibodies of high affinity and specificity for the digitalis glycoside digoxin
Smith, T. W., Butler, V. P., & Haber, E. (1970) · Biochemistry · doi:10.1021/bi00804a020 · Cited by 234
Self-citationPurification of antibodies with immunoadsorbents prepared using bromoacetyl cellulose
Robbins, J. B., Haimovich, J., & Sela, M. (1967) · Immunochemistry · doi:10.1016/0019-2791(67)90192-9 · Cited by 226
Suicidal and Accidental Digoxin Ingestion
Smith, T. W., & Willerson, J. T. (1971) · Circulation · doi:10.1161/01.cir.44.1.29 · Cited by 156
Self-citationKinetics of interactions between antibodies and haptens
Smith, T. W., & Skubitz, K. M. (1975) · Biochemistry · doi:10.1021/bi00678a023 · Cited by 69
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Cited by
Protein Therapeutics: A Summary and Pharmacological Classification
Leader, B., Baca, Q. J., & Golan, D. E. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2399 · Cited by 2,161
Mechanisms of ADC Toxicity and Strategies to Increase ADC Tolerability
Nguyen, T. D., Bordeau, B. M., & Balthasar, J. P. (2023) · Cancers · doi:10.3390/cancers15030713 · Cited by 441
Antman, E. M., Wenger, T. L., Butler, V. P., Haber, E., & Smith, T. W. (1990) · Circulation · doi:10.1161/01.cir.81.6.1744 · Cited by 393
Self-citation
Metadata
- Authors
- Smith, T. W., Haber, E., Yeatman, L., & Butler, V. P.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1976-04-08
- Volume
- 294
- Issue
- 15
- Pages
- 797-800
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2092694799
- Cited by
- 377
- References
- 8
- FWCI
- 55.75
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
