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Phospholipid composition of articular cartilage boundary lubricant

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Sarma, A. V., Powell, G. L., LaBerge, M.·2001·Journal of Orthopaedic Research
DOI 10.1016/s0736-0266(00)00064-4
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Abstract

The mechanism of lubrication in normal human joints depends on loading and velocity conditions. Boundary lubrication, a mechanism in which layers of molecules separate opposing surfaces, occurs under severe loading. This study was aimed at characterizing the phospholipid composition of the adsorbed molecular layer on the surface of normal cartilage that performs as a boundary lubricant. The different types of phospholipid adsorbed onto the surface of cartilage were isolated by extraction and identified by chromatography on silica gel paper and mass spectroscopy. The main phospholipid classes identified were quantified by a phosphate assay. Gas chromatography and electrospray ionization mass spectrometry were used to further characterize the fatty acyl chains in each major phospholipid component and to identify the molecular species present. Phosphatidylcholine (41%), phosphatidylethanolamine (27%) and sphingomyelin (32%) were the major components of the lipid layer on the normal cartilage surface. For each lipid type, a mixture of fatty acids was detected, with a higher percentage of unsaturated species compared to saturated species. The most abundant fatty acid observed with all three lipid types was oleic acid (C18:1). Additional work to further quantify the molecular species using electrospray ionization mass spectrometry is recommended. © 2001 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.

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Research works printed but not linked: 39

  1. 10.1016/0043-1648(69)90017-9 · DOI
  2. 10.1016/0005-2736(75)90188-1 · doi:10.1016/0005-2736(75)90188-1
  3. 10.1002/art.1780210703 · DOI
  4. Fein RS, 1984, CRC handbook of lubrication (Theory and practice of tribology), Volume II: Theory and design, 49
  5. Freeman MAR, 1972, Lubrication. Adult articular cartilage, 247
  6. Fuller DD, 1956, Theory and practice of lubrication for engineers, 342
  7. 10.1002/ls.3010090304 · doi:10.1002/ls.3010090304
  8. 10.1002/ls.3010090303 · doi:10.1002/ls.3010090303
  9. 10.1016/S0925-4439(98)00060-X · DOI · Paper page
  10. 10.1016/0304-4157(81)90007-1 · DOI · Paper page
  11. 10.1299/jsmec.40.776 · DOI
  12. 10.1007/BF02584258 · DOI
  13. 10.1093/rheumatology/37.2.143 · DOI
  14. 10.1093/oxfordjournals.rheumatology.a031463 · DOI
  15. Hills BA, 1989, Oligolamellar lubrication of joints by surface active phospholipid, J Rheumatol, 16, 82
  16. Hills BA, 1990, Oligolamellar nature of the articular surface, J Rheumatol, 17, 349
  17. Kahn MC, 1995, Phosphatidylcholine molecular species of calf lung surfactant, Am J Phys, 269, L567
  18. Kates M, 1972, Techniques of lipidology – Isolation, analysis and identification of lipids. Laboratory techniques in biochemistry and molecular biology, 428
  19. 10.1073/pnas.88.2.444 · DOI · Paper page
  20. Kumar VV, 1993, Lipid molecular shapes and membrane architecture, Indian J Biochem Biophys, 30, 135
  21. 10.1002/art.1780110510 · DOI
  22. 10.1007/BF02534277 · DOI
  23. McCutcheon CW, 1962, The frictional properties of animal joints, Wear, 5, 1, 10.1016/0043-1648(62)90176-X · DOI · Paper page
  24. 10.1016/S0006-3495(80)85128-9 · doi:10.1016/s0006-3495(80)85128-9
  25. Murakami T, 1998, Adaptive multimode lubrication in natural synovial joints and artificial joints, Proc Inst Mech Eng, 212, 23, 10.1243/0954411981533791 · DOI
  26. Ogston AG, 1953, The physiological function of hyaluronic acid in synovial fluid; viscous, elastic and lubricant properties, J Phys, 119, 244
  27. 10.1073/pnas.76.6.2750 · DOI · Paper page
  28. 10.1007/BF00270658 · DOI
  29. Rabinowitz JL, 1983, Lipid II. Synovial fluid in trauma, Clin Orthop, 190, 292
  30. Rogers JM, 1999, Effect of phospholipidic boundary lubrication in rigid and compliant hemiarthroplasty models, Proc Inst Mech Eng [H], 213, 5, 10.1243/0954411991534762 · DOI
  31. 10.1093/rheumatology/37.1.21 · DOI · Paper page
  32. 10.1093/rheumatology/35.9.821 · DOI
  33. Swann DA, 1977, The isolation and partial characterization of the major glycoprotein (LGP‐1) from the articular lubricating fraction from bovine synovial fluid, J Biochem, 161, 473, 10.1042/bj1610473 · DOI
  34. Swann DA, 1972, The molecular basis of articular lubrication, J Biol Chem, 274, 8069, 10.1016/S0021-9258(20)81810-9 · DOI
  35. 10.1002/art.1780240104 · DOI · Paper page
  36. 10.1136/ard.33.4.318 · DOI · Paper page
  37. Swann DA, 1981, The molecular structure of lubricating glycoprotein‐1, the boundary lubricant for articular cartilage, J Biol Chem, 256, 5921, 10.1016/S0021-9258(19)69297-5 · DOI · Paper page
  38. Swann DA, 1985, The molecular structure and lubricating activity of lubricin isolated from bovine and human synovial fluids, J Biochem, 225, 195, 10.1042/bj2250195 · DOI · Paper page
  39. Wüthier RE, 1968, Lipids of mineralized epiphyseal tissues in the bovine fetus, J Lipid Res, 9, 68, 10.1016/S0022-2275(20)43145-1 · DOI

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Metadata

Authors
Sarma, A. V., Powell, G. L., & LaBerge, M.
Venue
Journal of Orthopaedic Research
Publisher
Wiley
Published
2001-07
Volume
19
Issue
4
Pages
671-676
ISSN
  • 0736-0266 (ISSN-L)
  • 1554-527X
DOI
10.1016/s0736-0266(00)00064-4
OpenAlex
W2138948335
Cited by
174
References
2
FWCI
0.82
Type
journal article
Language
en
Open access
bronze
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1645 d)

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CoChat. (2026). Citation check: Phospholipid composition of articular cartilage boundary lubricant. https://app.cochat.ai/papers/10.1016/s0736-0266(00)00064-4
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Sarma, A. V., Powell, G. L., & LaBerge, M. (2001). Phospholipid composition of articular cartilage boundary lubricant. Journal of Orthopaedic Research. https://doi.org/10.1016/s0736-0266(00)00064-4

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.