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Cited by 177Lubricants and Their AdditivesOsteoarthritis Treatment and MechanismsTribology and Lubrication Engineering

Surfactants identified in synovial fluid and their ability to act as boundary lubricants.

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Hills, B.A, Butler, B.D·1984·Annals of the Rheumatic Diseases
DOI 10.1136/ard.43.4.641PMC PMC1001427
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Abstract

Thin-layer chromatography has been used to identify phospholipids extracted from canine synovial fluid, the major component (45%) being phosphatidyl choline (PC). The extracts and their components have been shown to be surface active in reducing the surface tension of water and to be readily adsorbed to hydrophilic solids, whose surfaces then become hydrophobic. These adsorbed monolayers of synovial surfactant were then found to be excellent boundary lubricants in vitro, reducing the coefficient of kinetic friction (mu) in the dry state and under physiological loading by up to 97% for extracts and 99% for PC alone, reaching mu = 0.01. Surface-active phospholipid is put forward as the possible active ingredient in joint lubrication and shown to be consistent with previous biochemical studies to elucidate its identity. The model essentially follows the classical Hardy model for boundary lubrication imparted by surfactants. It is discussed in relation to a new approach in providing artificial lubrication and facilitating tissue release in patients with arthritis.

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Crossref · 10.1136/ard.43.4.641

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  • The Hills picture (that surface-active phospholipids act in classical boundary lubrication mode with phosphocholine headgroups attached to cartilage surface and alkyl tails forming a close-packed layer sliding past a similar opposing layer) is unlikely to be correct.

    “so that the Hills picture is unlikely to be correct.”

    From Hydration lubrication (2013) · cites this paper as [125]

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Authors
Hills, B. A., & Butler, B. D.
Affiliations
The University of Texas Health Science Center at Houston (US)
Venue
Annals of the Rheumatic Diseases
Publisher
Elsevier BV
Published
1984-08
Volume
43
Issue
4
Pages
641-648
ISSN
0003-4967 (ISSN-L)
DOI
10.1136/ard.43.4.641
PMC
PMC1001427
OpenAlex
W2067877512
Cited by
177
References
49
Citations by year
2026: 8 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 13 · 2019: 2 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 7
FWCI
3.96
Type
journal article
Language
en
Open access
Licence
Locations
  • Annals of the Rheumatic Diseases (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Engineering › Mechanical Engineering › Lubricants and Their Additives
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Physical Sciences › Engineering › Mechanical Engineering › Tribology and Lubrication Engineering
Keywords
synovial fluid, phospholipids, phosphatidylcholine, boundary lubrication, joint lubrication, surfactants, adsorbed monolayers, surface tension reduction, sliding friction, arthritis
MeSH terms
Animals, Chromatography, Thin Layer, Dogs, Kinetics, Lubrication, Models, Biological, Phospholipids, Surface Properties, Surface-Active Agents, Synovial Fluid

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