The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.
The acquisition of motoneuron subtype identity and motor circuit formation
Abstract
Experiments in chick embryos using classical transplantation techniques introduced by Viktor Hamburger are reviewed; these demonstrated that chick-limb innervating motoneurons become specified by extrinsic signals prior to axon outgrowth and that they selectively grow to appropriate muscles by actively responding to guidance cues within the limb. More recent experiments reveal that fast/slow and flexor/extensor subclasses of motoneurons are distinct by E4-5 and that they exhibit patterned spontaneous activity while still growing to their targets. These observations are then related to the combinatorial code of LIM transcription factor expression, which has been hypothesized to specify motoneuron subtypes.
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“More than 50 distinct pools of MNs have been documented at limb levels of the spinal cord (Dasen et al., 2005; Landmesser, 2001; Philippidou and Dasen, 2013).”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Landmesser, 2001
In the citing paper
“There is a large diversity of cell types in the spinal cord. More than 50 distinct pools of MNs have been documented at limb levels of the spinal cord (Dasen et al., 2005; Landmesser, 2001; Philippidou and Dasen, 2013).”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Landmesser, 2001
Citations
Cites
The Molecular Biology of Axon Guidance
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Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
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Briscoe, J., Pierani, A., Jessell, T. M., & Ericson, J. (2000) · Cell · doi:10.1016/s0092-8674(00)80853-3 · Cited by 1,111
Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
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Kitsukawa, T., Shimizu, M., Sanbo, M., Hirata, T., Taniguchi, M., Bekku, Y., Yagi, T., & Fujisawa, H. (1997) · Neuron · doi:10.1016/s0896-6273(00)80392-x · Cited by 709
Requirement for the Homeobox Gene Hb9 in the Consolidation of Motor Neuron Identity
Arber, S., Han, B., Mendelsohn, M. M., Smith, M., Jessell, T. M., & Sockanathan, S. (1999) · Neuron · doi:10.1016/s0896-6273(01)80026-x · Cited by 607
Competition in Retinogeniculate Patterning Driven by Spontaneous Activity
Penn, A. A., Riquelme, P. A., Feller, M. B., & Shatz, C. J. (1998) · Science · doi:10.1126/science.279.5359.2108 · Cited by 514
The development of motor projection patterns in the chick hind limb.
Landmesser, L. T. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012546 · Cited by 430
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Cited by
Sorted by citations
A Hox regulatory network establishes motor neuron pool identity and target-muscle connectivity
Dasen, J. S., Tice, B. C., Brenner-Morton, S., & Jessell, T. M. (2005) · Cell · doi:10.1016/j.cell.2005.09.009 · Cited by 461
Hox Genes: Choreographers in Neural Development, Architects of Circuit Organization
Philippidou, P., & Dasen, J. S. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.020 · Cited by 423
Specificity of peripheral nerve regeneration: Interactions at the axon level
Allodi, I., Udina, E., & Navarro, X. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.005 · Cited by 422
Hanson, M. G., & Landmesser, L. T. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.018 · Cited by 378
Dasen, J. S., De Camilli, A., Wang, B., Tucker, P. W., & Jessell, T. M. (2008) · Cell · doi:10.1016/j.cell.2008.06.019 · Cited by 376
Metadata
- Authors
- Landmesser, L. T.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Landmesser, Lynn T.
- Venue
- International Journal of Developmental Neuroscience
- Publisher
- Wiley
- Published
- 2001-03-12
- Volume
- 19
- Issue
- 2
- Pages
- 175-182
- ISSN
- 0736-5748 (ISSN-L)
- 1873-474X
- OpenAlex
- W1978370395
- Cited by
- 136
- References
- 51
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 2 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 11
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Developmental Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIH (NS 19640, NS 23678)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- chick embryo, limb innervation, extrinsic signals, axon guidance, spontaneous activity
- MeSH terms
- Animals, Axons, Chick Embryo, Extremities, Gestational Age, Morphogenesis, Motor Neurons, Species Specificity, Transcription Factors, Transplantation, Heterologous, Homeodomain Proteins, Gene Expression Regulation, Developmental, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Cell Lineage, Mice
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