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Cited by 33

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Investigation of interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R) and soluble gp130 (sgp130) in sera of cancer patients

Kovacs, E·2001·Biomedicine & Pharmacotherapy
DOI 10.1016/s0753-3322(01)00079-8
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Abstract

The serum levels of interleukin-6 (IL-6), sIL-6R and sgp130 were investigated in 76 cancer patients in comparison with 28 healthy controls. IL-6 is a multifunctional cytokine involved in certain malignant diseases. Soluble IL-6 receptor as agonist enhances the biological effect of released IL-6. Soluble gp130 as antagonist inhibits the effect of the IL-6/sIL-6R complex. Patients with different types of tumour (breast/gastrointestinal/uterine/ovarian/renal/bladder) were divided into four groups according to tumour stage and previous therapy (stage I + II without or after chemo-/radiotherapy, stage III + IV without or after chemo-/radiotherapy). The distribution of different tumour histotypes was similar in each group of patients. The levels of the three serum parameters were determined by ELISA. At each tumour stage either without or after chemo-/radiotherapy, the serum values of IL-6 were found to be not significantly different from those of controls. The values of sIL-6R were significantly elevated in stage I + II (P < 0.02) patients, with a borderline significance in stage III + IV (P = 0.06), in both cases only when no additional therapy was initiated. The serum values of sgp130 increased significantly at each tumour stage both without and after chemo-/radiotherapy (P < 0.001). A significant correlation was found between the values of sIL-6R and sgp130 in stage I + II (P < 0.02) and III + IV (P < 0.004) patients, in both cases without chemo-/radiotherapy. There were no oth…

Overview

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Crossref · 10.1016/s0753-3322(01)00079-8

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Metadata

Authors
Kovacs, E.
Venue
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Published
2001-09
Volume
55
Issue
7
Pages
391-396
ISSN
0753-3322
DOI
10.1016/s0753-3322(01)00079-8
Cited by
33
References
30
Language
en
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.