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Olanzapine as an antiemetic in refractory nausea and vomiting in advanced cancer.
Open accessAbstract
Nausea and vomiting are difficult symptoms to manage in patients with advanced cancer. Several classes of antiemetics are available, including phenothiazines, butyrophenones, substituted benzamides and selective serotonin antagonists, as well as corticosteroids. Most patients will respond to either single agents or combinations that frequently include corticosteroids. A minority of patients will have nausea that fails to respond. The atypical antipsychotic, olanzapine, relieves nausea in some patients failing to respond to the usual antiemetics. Two case reports are presented and the rationale for olanzapine's benefit is discussed.
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Metadata
- Authors
- Srivastava, M., Brito-Dellan, N., Davis, M. P., Leach, M., & Lagman, R.
- Affiliations
- Cleveland Clinic (US)
- Corresponding author
- Davis, Mellar P
- Venue
- Journal of Pain and Symptom Management
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 25
- Issue
- 6
- Pages
- 578-582
- ISSN
- 0885-3924 (ISSN-L)
- OpenAlex
- W2028568939
- Cited by
- 106
- References
- 30
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 10 · 2020: 7 · 2019: 2 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 2
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Pain and Symptom Management (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Nausea and vomiting management
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
- Keywords
- olanzapine, antiemetics, refractory nausea and vomiting, advanced cancer, atypical antipsychotics, corticosteroids, combination antiemetic therapy
- MeSH terms
- Olanzapine, Adult, Aged, Antiemetics, Benzodiazepines, Breast Neoplasms, Female, Humans, Lung Neoplasms, Nausea, Pirenzepine, Vomiting
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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