The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
The enzyme indoleamine 2,3-dioxygenase is induced in the mouse brain in response to peripheral administration of lipopolysaccharide and superantigen
Abstract
The essential amino-acid, L-tryptophan, is the precursor of serotonin. Its availability in the brain is controlled by indoleamine 2,3-dioxygenase (IDO). This enzyme is inducible by cytokines such as interferon-gamma (IFN-gamma) and is the first and rate-limiting enzyme of the catabolism pathway of tryptophan. Since induction of IDO has been proposed to mediate the influence of cytokines on mood in patients with various somatic disorders, the present study aimed at analyzing the relationships between changes in brain IDO activity and serum IFN-gamma levels in response to peripheral immune stimulation by lipopolysaccharide (LPS) and superantigen in mice. Each of these treatments induced an increase in serum IFN-gamma at 6 h post-treatment followed 24 h later by a two-fold increase in IDO activity in the brain. These results support the involvement of peripheral IFN-gamma in the control of L-tryptophan catabolism in the brain.
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“In the brain, IDO activity is significantly increased at 24 hr and peaks at 48 hr in response to LPS administration, corresponding to the expression of some depressive-like behaviors, e.g. increased immobility in the forced-swim and tail suspension tests, in laboratory animals (Lestage et al., 2002, O'Connor et al., 2008).”
From Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications (2013) · cites this paper as Lestage et al., 2002
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Cites
Psychopharmacology: The Fourth Generation of Progress
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Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism
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Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels
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Cytokine-induced sickness behavior: where do we stand?
Dantzer, R. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2000.0613 · Cited by 862
Self-citationBrain Serotonin Content: Increase Following Ingestion of Carbohydrate Diet
Fernstrom, J. D., & Wurtman, R. J. (1971) · Science · doi:10.1126/science.174.4013.1023 · Cited by 734
Capuron, L., Ravaud, A., Neveu, P. J., Miller, A. H., Maes, M., & Dantzer, R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000995 · Cited by 473 · cited 2×
“This is not the case, however, for symptoms of depressed mood that coincide with decreased circulating levels of tryptophan (Capuron et al., 2002).”
BackgroundSelf-citationTakikawa, O., Kuroiwa, T., Yamazaki, F., & Kido, R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77982-4 · Cited by 472
The role of IFN-gamma in the pathology of experimental endotoxemia.
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Toxic shock syndrome toxin 1 as an inducer of human tumor necrosis factors and gamma interferon.
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Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Self-citationO'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278
Self-citationInflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180
Maes, M., Yirmyia, R., Noraberg, J., Brene, S., Hibbeln, J., Perini, G., Kubera, M., Bob, P., Lerer, B., & Maj, M. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-008-9118-1 · Cited by 894
Metadata
- Authors
- Lestage, J., Verrier, D., Palin, K., & Dantzer, R.
- Affiliations
- Inserm (FR)
- Corresponding author
- Lestage, J
- ORCID
- Dantzer, R
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2002-10
- Volume
- 16
- Issue
- 5
- Pages
- 596-601
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W1978589950
- Cited by
- 170
- References
- 34
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 1 · 2023: 6 · 2022: 7 · 2021: 11 · 2020: 5 · 2019: 4 · 2018: 10 · 2017: 12 · 2016: 13 · 2015: 11 · 2014: 7 · 2013: 7 · 2012: 8
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- indoleamine 2,3-dioxygenase, tryptophan catabolism, serotonin, interferon-gamma, lipopolysaccharide, superantigens, tryptophan
- MeSH terms
- Animals, Brain, Interferon-gamma, Lipopolysaccharides, Male, Mice, Inbred BALB C, Tryptophan, Tryptophan Oxygenase, Superantigens, Indoleamine-Pyrrole 2,3,-Dioxygenase, Mice
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