THE GROWTH WITHOUT GROWTH HORMONE SYNDROME
Abstract
The phenomenon of growth without GH has been recognized for over a quarter of a century in various physiologic or near-physiologic situations, including the fetal state and obesity, and in various obviously pathologic states, including postsurgical resection of suprasellar/hypothalamic tumors, most notably craniopharyngiomas, and in acromegaloidism. The mechanism or mechanisms responsible for this fascinating clinical syndrome are unknown. The available data implicate, at least in some of these subjects, a role for hypothalamic injury leading to obesity and insulin resistance which, in turn, leads to elevated circulating concentrations of insulin to which the body retains mitogenic sensitivity. Alternatively, in other subjects with this syndrome, evidence exists to support the presence of a circulating as yet incompletely characterized potent growth-promoting factor which appears in the serum. Further studies of this syndrome should help to enhance our knowledge of the mechanisms governing both normal and abnormal human growth.
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Children with untreated GHD have decreased linear growth.
“children with untreated GHD have decreased linear growth”
From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [25]
Sometimes when obesity is also present, children with untreated GHD do not have decreased linear growth (growth without GH).
“except sometimes when obesity is also present, so-called “growth without GH.” (25, 26)”
From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [25]
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Features of the metabolic syndrome after childhood craniopharyngioma
Srinivasan, S., Ogle, G. D., Garnett, S. P., Briody, J. N., Lee, J. W., & Cowell, C. T. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030442 · Cited by 211 · see citing works
Growth hormone replacement therapy in childhood-onset craniopharyngioma
van Iersel, L., van Schaik, J., & van Santen, H. M. (2025) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2025.101998 · Cited by 6 · see citing works
Approach to the patient with acquired hypothalamic syndrome
Grishman, E. K., & McCormack, S. E. (2026) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgag197
- Authors
- Geffner, M. E.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Geffner, Mitchell E.
- ORCID
- Geffner, Mitchell E.
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 1996-09
- Volume
- 25
- Issue
- 3
- Pages
- 649-663
- ISSN
- 0889-8529 (ISSN-L)
- OpenAlex
- W1976168090
- Cited by
- 108
- References
- 0
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 3 · 2021: 5 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 7 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 2 · 2012: 2
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology and Metabolism Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- growth hormone deficiency, craniopharyngioma, hypothalamic tumors, obesity, insulin resistance, insulin-like growth factor, fetal growth, hypothalamic injury
- MeSH terms
- Adult, Child, Craniopharyngioma, Embryonic and Fetal Development, Growth, Growth Disorders, Humans, Hypothalamic Diseases, Insulin, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Obesity, Pituitary Neoplasms, Prolactin, Sella Turcica, Syndrome, Human Growth Hormone
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