Cited by 12Platelet Disorders and TreatmentsBlood Coagulation and Thrombosis MechanismsReceptor Mechanisms and Signaling

Platelet receptors

Colman, Robert W.·1990·Hematology/Oncology Clinics of North America

Abstract

This article highlights the increasing knowledge of the biochemistry, pathology, and cell and molecular biology of platelet receptors. A receptor for ADP has been identified using the affinity label FSBA as aggregin, a 100-kd membrane protein, responsible for shape change, aggregation, and exposure of fibrinogen binding sites. A variety of putative receptors for collagen have been described with GP Ia and GP IV receiving the most attention recently. A thromboxane A2 receptor has been identified using receptor antagonists and photoaffinity labels. The alpha 2-adrenergic receptor has been cloned and expressed. The platelet thrombin receptor has been identified as GP Ib. Following binding of thrombin to this receptor, activation of calpain occurs with cleavage of aggregin leading to exposure of GP IIb/IIIa and platelet aggregation. Isolation, expression, or both of the ADP, collagen, and thrombin receptors as single gene products of the human platelet responsible for activation, and more complete understanding of stimulus-response coupling should allow for greater specificity of drugs with selective therapeutic actions.

Integrity signals

Registry

Crossref · 10.1016/s0889-8588(18)30504-5

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92 of 92 references verified0 citation errors · 0 not checkable

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Authors
Colman, R. W.
Affiliations
Temple University (US)
Corresponding author
Colman, Robert W.
Venue
Hematology/Oncology Clinics of North America
Publisher
Elsevier BV
Published
1990-02
Volume
4
Issue
1
Pages
27-42
ISSN
0889-8588 (ISSN-L)
OpenAlex
W4245028793
Cited by
12
References
92
Citations by year
2026: 1 · 2020: 1 · 2018: 1
FWCI
0.24
Type
journal article
Language
en
Open access
closed
Locations
  • Hematology/Oncology Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hl024365-11, 5p01hl036579-05)
  • National Heart, Lung, and Blood Institute (HL 24365, HL36579)
Topics
  • Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
platelet receptors, ADP receptor, collagen receptor, thromboxane A2 receptor, alpha2-adrenoceptors, protease-activated receptor 1, glycoprotein Ib, calpain, platelet aggregation, fibrinogen binding, stimulus-response coupling, platelet activation
MeSH terms
Adenosine Diphosphate, Animals, Blood Platelets, Collagen, Humans, Platelet Membrane Glycoproteins, Receptors, Adrenergic, alpha, Receptors, Cell Surface, Thrombin, Thromboxane A2, Platelet Activation

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