Cited by 272Point processes and geometric inequalitiesCell Image Analysis TechniquesCensus and Population Estimation

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Recommendations for straightforward and rigorous methods of counting neurons based on a computer simulation approach

Schmitz, Christoph, Hof, Patrick R·2000·Journal of Chemical Neuroanatomy

Open this paper in CoChat — free account

Abstract

Any investigation of the total number of neurons in a given brain region must first address the following questions. What is the best method for estimating the total number of neurons? What are the validity and the expected precision of the obtained data? What precision must the estimates attain with respect to the scientific question? In the present study, these questions were addressed using a computer simulation. Virtual brain regions with various spatial distributions of virtual neurons were modeled. The total numbers of virtual neurons in the modeled brain regions were repeatedly estimated by simulation of modern design-based stereology, either by using the 'fractionator' method or by the established method based on the product of estimated neuron density and estimated volume of the reference space. We show that estimates of total numbers of neurons obtained using the fractionator are from a statistical and economical standpoint more efficient than corresponding estimates obtained using the density/volume procedure. Furthermore, the use of two simple prediction methods (one for homogeneous and the other for clustered neuron distributions) permits satisfactory predictions about the variation of presumably any estimates of total numbers of neurons obtained using the fractionator. Finally, we show that assessing the reliability of estimates of mean total neuronal numbers using the ratio between the mean of the squared coefficients of error of the estimates and the squared coefficient of variation of the estimated total neuronal numbers, a frequently employed method in stereological studies, is neither useful nor informative. The present results may constitute a new set of recommendations for the rigorous usage of design-based stereology. In particular, we strongly recommend counting considerably more neurons than is currently done in the literature when estimating total neuronal numbers using design-based stereology.

Integrity signals

Registry

Crossref · 10.1016/s0891-0618(00)00066-1

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Art of Computer Programming
Knuth, D. E. (1968) · Cited by 16,097
The Art of Computer Programming. Volume 2: Seminumerical Algorithms.
Taussky, O., & Knuth, D. E. (1970) · American Mathematical Monthly · doi:10.2307/2317055 · Cited by 3,863
The efficiency of systematic sampling in stereology and its prediction*
Gundersen, H. J. G., & Jensen, E. B. V. (1987) · Journal of Microscopy · doi:10.1111/j.1365-2818.1987.tb02837.x · Cited by 3,519
Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
West, M. J., Slomianka, L., & Gundersen, H. J. G. (1991) · The Anatomical Record · doi:10.1002/ar.1092310411 · Cited by 2,994
Statistical analysis of spatial point patterns
(1986) · Environmental Software · doi:10.1016/0266-9838(86)90012-2 · Cited by 2,929
The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis
Gundersen, H. J. G., Bagger, P. V., Bendtsen, T. F., Evans, S. M., Korbo, L., Marcussen, N., Møller, A., Nielsen, K. N., Nyengaard, J. R., Pakkenberg, B., et al. (1988) · Apmis · doi:10.1111/j.1699-0463.1988.tb00954.x · Cited by 2,480
Stochastic Simulation
Ripley, B. D. (1987) · Wiley Series in Probability and Statistics · doi:10.1002/9780470316726 · Cited by 2,241
Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson.
Gundersen, H. J. G. (1986) · PubMed · Cited by 1,658
Stereology of arbitrary particles*
Gundersen, H. J. G. (1986) · Journal of Microscopy · doi:10.1111/j.1365-2818.1986.tb02764.x · Cited by 1,444
The efficiency of systematic sampling in stereology—reconsidered
GUNDERSEN, H. J. G., JENSEN, E. B. V., KIÊU, K., & NIELSEN, J. (1999) · Journal of Microscopy · doi:10.1046/j.1365-2818.1999.00457.x · Cited by 1,317

Show all 53 references

Research works printed but not linked: 2

Buffon, G.L.L.C, 1777. In: Essai d'Arithmétique Morale. Supplément à l'Histoire Naturelle, vol. 4, Imprimerie Royale, Paris.
Matheron, G., 1965. Les Variables Régionalisées et leur Estimation. Thesis, Masson et Cie, Paris.

Sorted by citations

Items 201–272 of 272

Antiseizure and Neuroprotective Efficacy of Midazolam in Comparison with Tezampanel (LY293558) against Soman-Induced Status Epilepticus
Figueiredo, T. H., Aroniadou‐Anderjaska, V., Pidoplichko, V. I., Apland, J. P., & Braga, M. F. M. (2022) · Toxics · doi:10.3390/toxics10080409 · Cited by 11
Cholinergic neurons in the basal forebrain of aged female mice
Kalesnykas, G., Puoliväli, J. T., Sirviö, J., & Miettinen, R. A. (2004) · Brain Research · doi:10.1016/j.brainres.2004.06.070 · Cited by 11
Humans and great apes share increased neocortical neuropeptide Y innervation compared to other haplorhine primates
Raghanti, M., Edler, M., Meindl, R., Sudduth, J., Bohush, T., Erwin, J., Stimpson, C., Hof, P., & Sherwood, C. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00101 · Cited by 9
Self-citation
Statistical and Economical Efficiency in Assessment of Liver Regeneration Using Defined Sample Size and Selection in Combination With a Fully Automated Image Analysis System
Deng, M., Kleinert, R., Huang, H., He, Q., Madrahimova, F., Dirsch, O., & Dahmen, U. (2009) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2009.953869 · Cited by 10
Neocortical synaptophysin asymmetry and behavioral lateralization in chimpanzees (Pan troglodytes)
Sherwood, C. C., Duka, T., Stimpson, C. D., Schenker-Ahmed, N. M., Garrison, A. R., Schapiro, S. J., Baze, W. B., McArthur, M. J., ERWIN, J. M., Hof, P. R., et al. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07168.x · Cited by 10
Self-citation
Decreased Neurogenesis Increases Spatial Reversal Errors in Chickadees (Poecile atricapillus)
Guitar, N. A., & Sherry, D. F. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22641 · Cited by 9
Adult hippocampal neurogenesis in Egyptian fruit bats from three different environments: Are interpretational variations due to the environment or methodology?
Chawana, R., Patzke, N., Bhagwandin, A., Kaswera‐Kyamakya, C., Gilissen, E., Bertelsen, M. F., Hemingway, J., & Manger, P. R. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24895 · Cited by 9
Preventing Long-Term Brain Damage by Nerve Agent–Induced Status Epilepticus in Rat Models Applicable to Infants: Significant Neuroprotection by Tezampanel Combined with Caramiphen but Not by Midazolam Treatment
Furtado, M. D. A., Aroniadou‐Anderjaska, V., Figueiredo, T. H., Pidoplichko, V. I., Apland, J. P., Rossetti, K., & Braga, M. F. M. (2023) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.123.001710 · Cited by 9
Quantification of neurons expressing androgen receptor and volume estimation of the basolateral nuclear group of the canine amygdaloid body
Jacobs, C., Broeck, W. V. D., & Simoens, P. (2005) · Brain Research Protocols · doi:10.1016/j.brainresprot.2005.04.004 · Cited by 9
Cellular and spatial changes in the anuran superior olive across metamorphosis
Templin, T., & Simmons, A. M. (2005) · Hearing Research · doi:10.1016/j.heares.2005.04.006 · Cited by 9
Maximizing Explanatory Power in Stereological Data Collection: A Protocol for Reliably Integrating Optical Fractionator and Multiple Immunofluorescence Techniques
Kreutz, A., & Barger, N. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00073 · Cited by 8
Delayed tezampanel and caramiphen treatment but not midazolam protects against long-term neuropathology after soman exposure
Figueiredo, T. H., Aroniadou‐Anderjaska, V., Apland, J. P., Rossetti, K., & Braga, M. F. M. (2023) · Experimental Biology and Medicine · doi:10.1177/15353702231171911 · Cited by 8
Cortical oscillations scan using chirp-evoked potentials in 6-hydroxydopamine rat model of Parkinson's disease
Pérez-Alcázar, M., Nicolás, M. J., Valencia, M., Alegre, M., López‐Azcárate, J., Iriarte, J., & Artieda, J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.11.031 · Cited by 8
Retinal topography in two species of flamingo (Phoenicopteriformes: Phoenicopteridae)
Lisney, T. J., Potier, S., Isard, P., Mentek, M., Mitkus, M., & Collin, S. P. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24902 · Cited by 8
The hippocampal formation of two carnivore species: The feliform banded mongoose and the caniform domestic ferret
Pillay, S., Bhagwandin, A., Bertelsen, M. F., Patzke, N., Engler, G., Engel, A. K., & Manger, P. R. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.25047 · Cited by 7
MPFC PV+ interneurons are involved in the antidepressant effects of running exercise but not fluoxetine therapy
Qin, L., Liang, X., Qi, Y., Luo, Y., Xiao, Q., Huang, D., Zhou, C., Jiang, L. H., Zhou, M., Zhou, Y., et al. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109669 · Cited by 7
MODERN STEREOLOGICAL EVALUATION IN THE AGING HUMAN SUBSTANTIA NIGRA
Ma, S. Y., Longo, F. M., Röyttä, M., & Collan, Y. U. (2011) · Image Analysis & Stereology · doi:10.5566/ias.v22.p73-80 · Cited by 7
High-Resolution Estimation of Multiple Cell Populations in Tissue Using Confocal Stereology
Peterson, D. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-409513-7.00012-9 · Cited by 6
A simple and efficient alternative to implementing systematic random sampling in stereological designs without a motorized microscope stage
Melvin, N. R., PODA, D., & Sutherland, R. J. (2007) · Journal of Microscopy · doi:10.1111/j.1365-2818.2007.01828.x · Cited by 6
Unchanged expression of the ceramide transfer protein in the acute 6-OHDA neurodegenerative model
Mencarelli, C., Bode, G. H., Vlamings, R., Janssen, M. L. F., Losen, M. H., Baets, M. H. D., Steinbusch, H. W. M., Temel, Y., & Martínez‐Martínez, P. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.10.044 · Cited by 6
Neurokinin-1 receptor in the basolateral nuclear group of the canine amygdala—Comparative study in normal and aggressive dogs
Jacobs, C., Broeck, W. V. D., & Simoens, P. (2006) · Brain Research · doi:10.1016/j.brainres.2006.04.099 · Cited by 6
Decreased neuronal and increased endothelial fractalkine expression are associated with neuroinflammation in Parkinson’s disease and related disorders
Chu, Y., Harms, A. S., Boehringer, A. V., & Kordower, J. H. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1557645 · Cited by 5
Systematic analysis of neuronal wiring of the rodent deep cerebellar nuclei reveals differences reflecting adaptations at the neuronal circuit and internuclear levels
Hamodeh, S., Baizer, J. S., Sugihara, I., & Sultan, F. R. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23545 · Cited by 6
Effects Of Pınealectomy On Morphologıcal Features Of Blood Vessel In Chıcken: An Electron Mıcroscopıc And Stereologıcal Study
Turgut, M., Kaplan, S., ÜNAL, Z. B., Altunkaynak, B. Z., ÜNAL, D., Şahin, B., BOZKURT, M., & Yurtseven, M. (2009) · Journal of Experimental and Clinical Medicine · doi:10.5835/jecm.omu.26.03.003 · Cited by 5
Hidden brain atrophy in ultra-high field MR images in a transgenic rat model of Huntington's disease
Jahanshahi, A., Boonstra, J. T., Alosaimi, F., Özsoy, Ö., Michielse, S., & Temel, Y. (2022) · Brain Disorders · doi:10.1016/j.dscb.2022.100039 · Cited by 6
Effects of Constant Lightness, Darkness and Parachlorophenylalanine Treatment on Tail Regeneration in the Lizard Ophisops elegans macrodactylus: Macroscopic, Biochemical and Histological Changes
Turgut, M., Kaplan, S., Metin, K., Koca, Y. B., Soylu, E., Şahin, B., Ateşlier, Z. B. B., & Başaloğlu, H. (2006) · Anatomia Histologia Embryologia · doi:10.1111/j.1439-0264.2005.00653.x · Cited by 5
Prenatal Programming of Depression and Schizophrenia?
Dafotakis, M., Vehoff, J., Korr, H., & Schmitz, C. (2002) · Neuroembryology and Aging · doi:10.1159/000063531 · Cited by 5
Self-citation
Sex-dependent differences in the antiseizure and neuroprotective effects of midazolam after soman exposure: Superior, sex-independent efficacy of tezampanel and caramiphen
Figueiredo, T. H., Aroniadou‐Anderjaska, V., Pidoplichko, V. I., Furtado, M. D. A., Rossetti, K., Lumley, L. A., & Braga, M. F. M. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115412 · Cited by 4
Does prenatal exposure to diclofenac sodium affect the total number of cerebellar granule cells in male juvenile and adult rats?
Ekici, F., Keskin, İ., Aslan, H., Erişgin, Z., Altunkaynak, B. Z., Gökçımen, A., Odacı, E., & Kaplan, S. (2012) · Journal of Experimental and Clinical Medicine · doi:10.5835/jecm.omu.29.01.013 · Cited by 4
The density of calretinin striatal interneurons is decreased in 6-OHDA-lesioned mice
Petryszyn, S., Saidi, L., Gagnon, D., Parent, A., & Parent, M. (2021) · Brain Structure and Function · doi:10.1007/s00429-021-02298-5 · Cited by 4
3D segmentation of neuronal nuclei and cell-type identification using multi-channel information
LaTorre, A., Alonso‐Nanclares, L., Peña, J. M., & DeFelipe, J. (2021) · Expert Systems with Applications · doi:10.1016/j.eswa.2021.115443 · Cited by 4
The Optical Fractionator Technique to Estimate Cell Numbers in a Rat Model of Electroconvulsive Therapy
Olesen, M. V., Needham, E. K., & Pakkenberg, B. (2017) · Journal of Visualized Experiments · doi:10.3791/55737-v · Cited by 4
Joint immobilization increases reactive oxygen species: an experimental study
Erdem, M. N., Gunes, T., Sen, C., Bostan, B., Aslan, H., Ozyurt, H., & Koseoglu, R. D. (2009) · Acta Orthopaedica et Traumatologica Turcica · doi:10.3944/aott.2009.436 · Cited by 4
Quantitative stereology: the use of camera lucida for counting neurons by physical dissector method in chick brainstem auditory nuclei.
Wadhwa, S. (2003) · PubMed · Cited by 3
Fetal inflammatory injury as origin of long term disease : lessons from animal models
Gantert, M. (2014) · doi:10.26481/dis.20140131mg · Cited by 3
Applicability of image analysis of neurons and neuroglia of fundus striati using cell profiler software
Kulkarni, V., & Ramesh, B. (2018) · MOJ Anatomy & Physiology · doi:10.15406/mojap.2018.05.00201 · Cited by 2
REVIEW DESIGN-BASED STEREOLOGY IN NEUROSCIENCE
Schmitz, C., & Hof, P. R. (2005) · Cited by 2
Self-citation
Effects of Ca2+ channel blocker verapamil on tissue regeneration in a lizard tail autotomy model: a biochemical and histological study
Turgut, M., Koca, Y. B., Kaplan, S., Metin, K., Üzüm, N., Soylu, E., Avcı, A., Rağbetli̇, M. Ç., Beytaş, E. P., & Olgun, K. (2007) · Amphibia-Reptilia · doi:10.1163/156853807779798992 · Cited by 1
ImageJ-FIJI-Assisted Estimation of Intestinal Layers’ Volume: Study in Jejunum–Ileum of Rats
Wicaksono, S. A., Sumiwi, Y. A. A., Paramita, D. K., & Susilowati, R. (2022) · Journal of Microscopy and Ultrastructure · doi:10.4103/jmau.jmau_53_22 · Cited by 1
Structural plasticity of the serotonergic and dopaminergic systems : a multidisciplinary approach
Jahanshahi, A. (2012) · Research Publications (Maastricht University) · doi:10.26481/dis.20120523aj
The subthalamic nucleus : a novel motor-associative-limbic interface
Temel, Y. (2007) · doi:10.26481/dis.20070202yt
Role of the N-methyl-D-aspartate receptor (NMDAR)-NR2b subunit in female reproductive aging
Maffucci, J. A. (2008) · Texas ScholarWorks (Texas Digital Library)
ENSAIOS ESTEREOLÓGICOS E MORFOLOGIA TRIDIMENSIONAL NA FORMAÇÃO HIPOCAMPAL DE AVES MIGRATÓRIAS MARINHAS: Análise quantitativa da imunomarcação seletiva de neurônios e micróglia em Calidris pusilla e Actitis macularia.
Diniz, C. G. (2013) · Americanae (AECID Library) · doi:10.13140/rg.2.1.2292.0165
Avaliação estereológica da microestrutura do fígado em animais desnutridos e submetidos à renutrição protéica
Gomes, S. P. (2011) · doi:10.11606/t.10.2011.tde-24092012-140205
Novel insights towards memory restoration
Hescham, S.-A. (2015) · Research Publications (Maastricht University) · doi:10.26481/dis.20151215sh
A stereological approach to measuring striatal cellular changes in transgenic Huntington's disease rats
Jain, S. (2010) · NORA - Norwegian Open Research Archives
Mehr als 85% aller Granularzellen im menschlichen Kleinhirn entstehen postnatal - ohne Unterschied zwischen plötzlichem Kindstod und Kontrollfällen
Schmitz, C. (2013)
Self-citation
Gene therapy and cellular transplantation : towards a combination strategy for spinal cord injury repair.
Abdellatif, A. (2007) · doi:10.18297/etd/2
Neurostimulation to treat brain injury?
Schönfeldt, L. (2016) · doi:10.26481/dis.20160610ls
The link between ceramide transporters, innate immunity and Alzheimer’s disease
Bode, G. H. (2016) · Research Publications (Maastricht University) · doi:10.26481/dis.20161014gb
Pathophysiological Roles of Brain Aquaporins in Parkinson’s Disease and Aging
Stahl, K. (2018) · NORA - Norwegian Open Research Archives
Deep brain stimulation and memory functions
Aldehri, M. (2020) · doi:10.26481/dis.20200710ma
Chronic High-frequency Stimulation of the Subthalamic Nucleus Induces a Sustained Inhibition of Serotonergic System via Loss of Cell PhenotypePreprint
Alosaimi, F., Temel, Y., Hescham, S., Witzig, V. S., Almasabi, F., Tan, S. K. H., & Jahanshahi, A. (2022) · Research Square · doi:10.21203/rs.3.rs-1227919/v1
Faculty Opinions recommendation of Histological asymmetries of primary motor cortex predict handedness in chimpanzees (Pan troglodytes).
MacNeilage, P. F. (2007) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1086989.539946
Deep Brain Stimulation and memory restoration
Liu, H. (2022) · doi:10.26481/dis.20221003hl
The Tangled Principle of the Democratic Peace
Cartwright, N. D., Hardie, J. M., Montuschi, E., Soleiman, M. T., & Thresher, A. C. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780198866343.003.0007
Copyright Page
Cartwright, N. D., Hardie, J. M., Montuschi, E., Soleiman, M., & Thresher, A. C. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780198866343.002.0003
Illustrating the Tangle
Cartwright, N. D., Hardie, J. M., Montuschi, E., Soleiman, M. T., & Thresher, A. C. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780198866343.003.0006
List of Figures
Cartwright, N. D., Hardie, J. M., Montuschi, E., Soleiman, M., & Thresher, A. C. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780198866343.002.0007
Objectivity
Cartwright, N. D., Hardie, J. M., Montuschi, E., Soleiman, M. T., & Thresher, A. C. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780198866343.003.0004
Rigour
Cartwright, N. D., Hardie, J. M., Montuschi, E., Soleiman, M. T., & Thresher, A. C. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780198866343.003.0003
Frontispiece
Cartwright, N. D., Hardie, J. M., Montuschi, E., Soleiman, M., & Thresher, A. C. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780198866343.002.0004
Scientific Method
Cartwright, N. D., Hardie, J. M., Montuschi, E., Soleiman, M. T., & Thresher, A. C. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780198866343.003.0002
A Cautionary Lesson
Cartwright, N. D., Hardie, J. M., Montuschi, E., Soleiman, M. T., & Thresher, A. C. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780198866343.003.0008
The Tangle
Cartwright, N. D., Hardie, J. M., Montuschi, E., Soleiman, M. T., & Thresher, A. C. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780198866343.003.0005
Introduction
Cartwright, N. D., Hardie, J. M., Montuschi, E., Soleiman, M. T., & Thresher, A. C. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780198866343.003.0001
Microglial depletion and repopulation did not affect hippocampal neurogenesis after whole brain irradiationPreprint
Zhou, K., Zisiadis, G. A., Havermans, M., Dominguez, C. A., Ohshima, M., Rodrigues, C. F. D., & Blomgren, K. (2023) · Research Square · doi:10.21203/rs.3.rs-2681591/v1
Release and Reuptake Sites for Norepinephrine Are Differently Distributed Across Layers of the Primary Visual Cortex in Macaque Monkeys
Roach, C., Rios, R., Pearson, J., & Disney, A. A. (2025) · The Journal of Comparative Neurology · doi:10.1002/cne.70110
Persistently Elevated Gamma Power and Delayed Brain Damage in Aged Rats Acutely Exposed to Soman Without Status Epilepticus: Comparisons with Seizing Rats Treated with Midazolam or with Tezampanel and Caramiphen
Figueiredo, T. H., Aroniadou‐Anderjaska, V., Furtado, M. D. A., Pidoplichko, V. I., Rossetti, K., Lumley, L. A., & Braga, M. F. M. (2025) · Toxics · doi:10.3390/toxics14010022
A single exposure to an organophosphate insecticide disrupts developmental patterns of hippocampal cell proliferation and overall brain size in a migratory songbird
Moore, S., Eng, M. L., Pereira, P. D. C., Wein, J., Bottini, C., Morrissey, C. A., & Guigueno, M. F. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120769
Ceramide transporters in neuroinflammation and neurodegenerative diseases
Mencarelli, C. (2012) · Research Publications (Maastricht University) · doi:10.26481/dis.20120627cm
Impact of stress exposure and pharmacological intervention on a mouse model of Alzheimer’s disease
Sierksma, S. R. (2012) · Research Publications (Maastricht University) · doi:10.26481/dis.20121220ss

Authors: Schmitz, C., & Hof, P. R.
Affiliations: RWTH Aachen University (DE)
Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Schmitz, Christoph
ORCID: Schmitz, Christoph
Hof, Patrick R
Venue: Journal of Chemical Neuroanatomy
Publisher: Elsevier BV
Published: 2000-10
Volume: 20
Issue: 1
Pages: 93-114
ISSN: 0891-0618 (ISSN-L)
DOI: 10.1016/s0891-0618(00)00066-1
OpenAlex: W2168092251
Cited by: 272
References: 53
Citations by year: 2026: 1 · 2025: 4 · 2024: 1 · 2023: 5 · 2022: 22 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 12 · 2017: 6 · 2016: 10 · 2015: 11 · 2014: 11 · 2013: 11 · 2012: 16
FWCI: 23.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Chemical Neuroanatomy (publishedVersion)
PubMed (publishedVersion)
RWTH Publications (RWTH Aachen) (submittedVersion)
Funders: National Institutes of Health
National Institute on Aging (AG-02219, AG 05138, P50AG005138, P01AG002219)
National Institute of Mental Health (MH-58911, P50MH058911)
Topics: Physical Sciences › Mathematics › Applied Mathematics › Point processes and geometric inequalities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
Physical Sciences › Mathematics › Statistics and Probability › Census and Population Estimation
Keywords: neuron counting, design-based stereology, neuronal density, coefficient of variation, estimation precision
MeSH terms: Algorithms, Brain, Cell Count, Computer Simulation, Image Interpretation, Computer-Assisted, Models, Neurological, Terminology as Topic, Random Allocation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Recommendations for straightforward and rigorous methods of counting neurons based on a computer simulation approach

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks