Cited by 800Selenium in Biological SystemsRedox biology and oxidative stressAntioxidant Activity and Oxidative Stress

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The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

Yant, Levi J, Ran, Qitao, Rao, Lin, Van Remmen, Holly, Shibatani, Toru, Belter, Jason G, Motta, Lucia, Richardson, Arlan, Prolla, Tomas A·2003·Free Radical Biology and Medicine

DOI 10.1016/s0891-5849(02)01360-6

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Abstract

Lipid peroxidation has been implicated in a variety of pathophysiological processes, including inflammation, atherogenesis, neurodegeneration, and the ageing process. Phospholipid hydroperoxide glutathione peroxidase (GPX4) is the only major antioxidant enzyme known to directly reduce phospholipid hydroperoxides within membranes and lipoproteins, acting in conjunction with alpha tocopherol (vitamin E) to inhibit lipid peroxidation. Here we describe the generation and characterization of GPX4-deficient mice by targeted disruption of the murine Gpx4 locus through homologous recombination in embryonic stem cells. Gpx4(-/-) embryos die in utero by midgestation (E7.5) and are associated with a lack of normal structural compartmentalization. Gpx4(+/-) mice display reduced levels of Gpx4 mRNA and protein in various tissues. Interestingly, cell lines derived from Gpx4(+/-) mice are markedly sensitive to inducers of oxidative stress, including gamma-irradiation, paraquat, tert-butylhydroperoxide, and hydrogen peroxide, as compared to cell lines derived from wild-type control littermates. Gpx4(+/-) mice also display reduced survival in response to gamma-irradiation. Our observations establish GPX4 as an essential antioxidant enzyme in mice and suggest that it performs broad functions as a component of the mammalian antioxidant network.

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Additional file 6 of Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia
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Additional file 1 of Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia
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Additional file 7 of Identification the ferroptosis-related gene signature in patients with esophageal adenocarcinoma
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Additional file 7 of Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia
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Additional file 3 of Identification the ferroptosis-related gene signature in patients with esophageal adenocarcinoma
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Additional file 3 of Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia
Feng, S., Yuan, Y., Lin, Z., Li, M., Ye, D., Shi, L., Li, D., Zhao, M., Meng, C., He, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26683045
Additional file 5 of Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia
Feng, S., Yuan, Y., Lin, Z., Li, M., Ye, D., Shi, L., Li, D., Zhao, M., Meng, C., He, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26683051
Additional file 11 of Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia
Feng, S., Yuan, Y., Lin, Z., Li, M., Ye, D., Shi, L., Li, D., Zhao, M., Meng, C., He, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26683072
Additional file 1 of Identification the ferroptosis-related gene signature in patients with esophageal adenocarcinoma
Zhu, L., Yang, F., Lingwei, W., Dong, L., Huang, Z., Wang, G., Chen, G., & Li, Q. (2021) · Figshare · doi:10.6084/m9.figshare.14059369
Additional file 9 of Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia
Feng, S., Yuan, Y., Lin, Z., Li, M., Ye, D., Shi, L., Li, D., Zhao, M., Meng, C., He, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26683066
Additional file 10 of Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia
Feng, S., Yuan, Y., Lin, Z., Li, M., Ye, D., Shi, L., Li, D., Zhao, M., Meng, C., He, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26683069
Additional file 13 of Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia
Feng, S., Yuan, Y., Lin, Z., Li, M., Ye, D., Shi, L., Li, D., Zhao, M., Meng, C., He, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26683078
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Additional file 2 of Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia
Feng, S., Yuan, Y., Lin, Z., Li, M., Ye, D., Shi, L., Li, D., Zhao, M., Meng, C., He, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25256114
Additional file 12 of Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia
Feng, S., Yuan, Y., Lin, Z., Li, M., Ye, D., Shi, L., Li, D., Zhao, M., Meng, C., He, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26683075
Additional file 8 of Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia
Feng, S., Yuan, Y., Lin, Z., Li, M., Ye, D., Shi, L., Li, D., Zhao, M., Meng, C., He, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26683060
Additional file 4 of Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia
Feng, S., Yuan, Y., Lin, Z., Li, M., Ye, D., Shi, L., Li, D., Zhao, M., Meng, C., He, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26683048
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Authors: Yant, L. J., Ran, Q., Rao, L., Van Remmen, H., Shibatani, T., Belter, J. G., Motta, L., Richardson, A., & Prolla, T. A.
Affiliations: University of Wisconsin–Madison (US)
The University of Texas at San Antonio Health Science Center (US)
Corresponding author: Prolla, Tomas A
ORCID: Yant, Levi J
Ran, Qitao
Rao, Lin
Richardson, Arlan
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2003-02
Volume: 34
Issue: 4
Pages: 496-502
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/s0891-5849(02)01360-6
OpenAlex: W2165072468
Cited by: 797
References: 26
Citations by year: 2026: 29 · 2025: 41 · 2024: 82 · 2023: 59 · 2022: 52 · 2021: 51 · 2020: 43 · 2019: 32 · 2018: 39 · 2017: 35 · 2016: 22 · 2015: 27 · 2014: 27 · 2013: 24 · 2012: 26
FWCI: 16.61
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
National Institutes of Health
University of Texas Health Science Center at San Antonio
National Institute on Aging (P03-AG13319, 1 P01 AG19316, P01AG019316)
National Cancer Institute
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: GPX4, phospholipid hydroperoxide glutathione peroxidase, selenoproteins, lipid peroxidation, antioxidant enzymes, embryonic lethality, oxidative stress, gamma-irradiation sensitivity, paraquat, tert-butyl hydroperoxide, hydrogen peroxide, vitamin E, mouse development
MeSH terms: Phospholipid Hydroperoxide Glutathione Peroxidase, Animals, Cell Line, Embryo, Mammalian, Female, Fetal Death, Embryonic and Fetal Development, Fibroblasts, Gamma Rays, Gestational Age, Glutathione Peroxidase, Hydrogen Peroxide, Mice, Inbred C57BL, Paraquat, Pregnancy, RNA, Messenger, Blotting, Northern, Blotting, Western, Mice, Knockout, Oxidative Stress, tert-Butylhydroperoxide, In Situ Nick-End Labeling, Mice

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The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

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