Postprandial plasma lipid hydroperoxides: a possible link between diet and atherosclerosis
Abstract
There is increasing evidence implicating a dietary source of plasma lipid peroxides that become elevated in the postprandial state. This phenomenon may be a contributing factor to the correlation found between postprandial hyperlipidemia and increased risk of cardiovascular disease. Using a newly developed method for measuring lipid hydroperoxides directly in plasma, a pilot study was performed which revealed that lipid hydroperoxides are indeed elevated following a fatty meal. Lipid hydroperoxides increased within 2-4 h after the meal and returned to basal levels, corresponding to the usual postprandial hyperlipidemia. A marked suppression of postprandial hydroperoxides was found when a meal was consumed with wine, suggesting that these hydroperoxides can be formed and then absorbed during the digestive process.
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In healthy animals, advanced glycation end products are rapidly and completely excreted.
“Little is known about possible tissue deposition of food-derived AGE but in healthy animals, it has been shown that AGE are rapidly and completely excreted (464,465) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [465]
Studies in experimental animals and human volunteers show that absorption of ingested Maillard reaction products is variable and dependent on the Maillard reaction product.
“Studies in experimental animals fed or injected with radiolabelled protein-bound AGE and human volunteers receiving diets enriched with MRP or specific AGE have shown that absorption of ingested MRP is variable and dependent on the MRP (464,465,527 -529) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [465]
Highly cross-linked advanced glycation end products and melanoidins are predominantly excreted in faeces, while absorbed Maillard reaction products are generally rapidly excreted by the kidney with limited accumulation in tissues and organs.
“Highly cross-linked AGE and melanoidins were predominantly excreted in the faeces while absorbed MRP were in general rapidly excreted by the kidney, with limited accumulation in tissues and organs (465,528 -531) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [465]
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References 14 · Cited by 172
- Authors
- Ursini, F., Zamburlini, A., Cazzolato, G., Maiorino, M., Bon, G. B., & Sevanian, A.
- Affiliations
- University of Padua (IT)
- University of Southern California (US)
- Corresponding author
- Ursini, Fulvio
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 1998-07
- Volume
- 25
- Issue
- 2
- Pages
- 250-252
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2022016683
- Cited by
- 172
- References
- 14
- Citations by year
- 2024: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 7 · 2015: 8 · 2014: 2 · 2013: 9 · 2012: 15
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- lipid hydroperoxides, postprandial lipemia, atherosclerosis, dietary fat, wine, fatty meal, cardiovascular risk, lipid peroxidation, plasma lipid peroxides
- MeSH terms
- Adult, Animals, Antioxidants, Arteriosclerosis, Dietary Fats, Free Radicals, Humans, Inflammation, Lipid Peroxides, Lipoproteins, LDL, Lipoproteins, VLDL, Lipoxygenase, Male, Middle Aged, Pilot Projects, Wine, Risk Assessment, Postprandial Period
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