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Trapping of free radicals with direct in vivo EPR detection: a comparison of 5,5-dimethyl-1-pyrroline-N-oxide and 5-diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide as spin traps for HO and SO4•−
Open accessAbstract
To spin trap hydroxyl radical (HO*) with in vivo detection of the resultant radical adducts, the use of two spin traps, 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and 5-diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide (DEPMPO) (10 mmol/kg) has been compared. In mice treatment with 5-aminolevulinic acid and Fe3+ resulted in detection of adducts of hydroxyl radicals (HO*), but only with use of DEPMPO. Similarly, 'HO* adducts' generated via nucleophilic substitution of SO4*- adducts formed in vivo could be observed only when using DEPMPO as the spin trap. The reasons for the differences observed between DEPMPO and DMPO are likely due to different in vivo lifetimes of their hydroxyl radical adducts. These results seem to be the first direct in vivo EPR detection of hydroxyl radical adducts.
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Karoui, H., Hogg, N., Fréjaville, C., Tordo, P., & Kalyanaraman, B. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6000 · Cited by 231
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Metadata
- Authors
- Timmins, G. S., Liu, K. J., Bechara, E. J. H., Kotake, Y., & Swartz, H. M.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 27
- Issue
- 3-4
- Pages
- 329-333
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W1972167590
- Cited by
- 299
- References
- 1
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Trapping of free radicals with direct in vivo EPR detection: a comparison of 5,5-dimethyl-1-pyrroline-N-oxide and 5-diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide as spin traps for HO and SO4•−. https://app.cochat.ai/papers/10.1016/s0891-5849(99)00049-0
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- Timmins, G. S., Liu, K. J., Bechara, E. J. H., Kotake, Y., & Swartz, H. M. (1999). Trapping of free radicals with direct in vivo EPR detection: a comparison of 5,5-dimethyl-1-pyrroline-N-oxide and 5-diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide as spin traps for HO and SO4•−. Free Radical Biology and Medicine. https://doi.org/10.1016/s0891-5849(99)00049-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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