The Effects of Total Sleep Deprivation on Cerebral Responses to Cognitive Performance
Abstract
We review the findings from a study utilizing functional magnetic resonance imaging (FMRI) to examine the effects of total sleep deprivation (TSD) on verbal learning, arithmetic, and divided attention. For verbal learning and divided attention, TSD was associated with increased activation in the bilateral prefrontal cortex and parietal lobes. Increased sleepiness after TSD and lower levels of memory impairment were correlated with increased activation in specific regions of the prefrontal cortex and parietal lobes, respectively. The arithmetic task led to significantly decreased activation in the bilateral prefrontal cortex and parietal lobes. Based on this and other data, we hypothesize an adaptive cerebral response during cognitive performance following TSD with the specific pattern of adaptation depending on the specific cognitive processes performed. We discuss the need to test the hypothesis in a variety of ways.
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There is convergent evidence in humans and rats for an impairment of learning when they were deprived of sleep.
“Indeed, there is convergent evidence for such action in humans and rats, i.e., an impairment of learning when they were deprived of sleep (195,328,500,634,759,1291,1345).”
From About Sleep's Role in Memory (2013) · cites this paper as [328]
Prior sleep deprivation impairs verbal learning ability and reduces temporal lobe activation during learning.
“Prior sleep deprivation impairs verbal learning ability and reduces temporal lobe activation during learning (328,329).”
From About Sleep's Role in Memory (2013) · cites this paper as [328]
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References 21 · Cited by 306
- Authors
- Drummond, S.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Drummond, S
- ORCID
- Drummond, S
- Venue
- Neuropsychopharmacology
- Published
- 2001-11
- Volume
- 25
- Issue
- 5
- Pages
- S68-S73
- ISSN
- 0893-133X (ISSN-L)
- OpenAlex
- W1992321312
- Cited by
- 306
- References
- 21
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 16 · 2023: 5 · 2022: 11 · 2021: 14 · 2020: 7 · 2019: 10 · 2018: 11 · 2017: 12 · 2016: 12 · 2015: 15 · 2014: 14 · 2013: 13 · 2012: 18
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- University of California, San Diego
- National Institute of Mental Health
- NIH Clinical Center
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Keywords
- total sleep deprivation, brain activation, prefrontal cortex, parietal lobe, verbal learning, arithmetic, divided attention, sleepiness, memory impairment, cognitive performance, brain adaptation
- MeSH terms
- Adaptation, Physiological, Attention, Cognition, Humans, Magnetic Resonance Imaging, Parietal Lobe, Problem Solving, Sleep Deprivation, Verbal Learning, Prefrontal Cortex
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