The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Serotonin and Hallucinogens
Abstract
This brief review traces the serotonin (5-HT) hypothesis of the action of hallucinogenic drugs from the early 1950s to the present day. There is now converging evidence from biochemical, electrophysiological, and behavioral studies that the two major classes of psychedelic hallucinogens, the indoleamines (e.g., LSD) and the phenethylamines (e.g., mescaline), have a common site of action as partial agonists at 5-HT2A and other 5-HT2 receptors in the central nervous system. The noradrenergic locus coeruleus and the cerebral cortex are among the regions where hallucinogens have prominent effects through their actions upon a 5-HT2A receptors. Recently, we have observed a novel effect of hallucinogens--a 5-HT2A receptor-mediated enhancement of nonsynchronous, late components of glutamatergic excitatory postsynaptic potentials at apical dendrites of layer V cortical pyramidal cells. We propose that an effect of hallucinogens upon glutamatergic transmission in the cerebral cortex may be responsible for the higher-level cognitive, perceptual, and affective distortions produced by these drugs.
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“Indirectly, psychedelics influence plasticity via the expression of BDNF and other plasticity-related genes and proteins, including IEGs (91, 93).”
From Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics. (2021) · cites this paper as [91]
In the citing paper
“This increases AMPAR density, resulting in more extracellular glutamate and BDNF release in the cortex (86, 91).”
From Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics. (2021) · cites this paper as [91]
Citations
Cites
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Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents
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A BIOCHEMICAL AND PHARMACOLOGICAL SUGGESTION ABOUT CERTAIN MENTAL DISORDERS
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SERUM VASOCONSTRICTOR (SEROTONIN)
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Molecular, pharmacological and functional diversity of 5-HT receptors
Hoyer, D., Hannon, J. P., & Martin, G. R. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00746-8 · Cited by 1,898
Nichols, D. E. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011478 · Cited by 1,762
Nichols, D. E., & Nichols, C. D. (2008) · Chemical Reviews · doi:10.1021/cr078224o · Cited by 895
Opponent interactions between serotonin and dopamine
Daw, N. D., Kakade, S., & Dayan, P. (2002) · Neural Networks · doi:10.1016/s0893-6080(02)00052-7 · Cited by 844
Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder
Moreno, F. A., Wiegand, C. B., Taitano, E. K., & Delgado, P. L. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n1110 · Cited by 789
Metadata
- Authors
- Aghajanian, G.
- Affiliations
- Yale University (US)
- Corresponding author
- Aghajanian, G
- Venue
- Neuropsychopharmacology
- Published
- 1999-08
- Volume
- 21
- Issue
- 2
- Pages
- 16S-23S
- ISSN
- 0893-133X (ISSN-L)
- OpenAlex
- W2075352853
- Cited by
- 371
- References
- 45
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 11 · 2020: 9 · 2019: 10 · 2018: 18 · 2017: 17 · 2016: 15 · 2015: 13 · 2014: 12 · 2013: 14 · 2012: 8
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- serotonin, hallucinogens, 5-HT2A receptor, psychedelics, indoleamines, phenethylamines, LSD, mescaline, locus coeruleus, cerebral cortex, glutamatergic neurotransmission, excitatory postsynaptic potentials, cortical pyramidal neurons
- MeSH terms
- Animals, Cerebral Cortex, Hallucinogens, Humans, Synaptic Transmission, Receptors, Serotonin, Serotonin, Pyramidal Cells, Receptor, Serotonin, 5-HT2A
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