Aghajanian, George K.

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 2,881

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

Duman, R. S., Aghajanian, G. K., Sanacora, G., & Krystal, J. H. (2016) · Nature Medicine

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 1,750

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

Duman, R. S., & Aghajanian, G. K. (2012) · Science

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 1,651

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

Li, N., Liu, R.-J., Dwyer, J. M., Banasr, M., Lee, B., Son, H., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2011) · Biological Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 1,082

Signaling pathways underlying the rapid antidepressant actions of ketamine

Duman, R. S., Li, N., Liu, R.-J., Duric, V., & Aghajanian, G. (2012) · Neuropharmacology

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 537

Serotonin model of schizophrenia: emerging role of glutamate mechanisms

Aghajanian, G. (2000) · Brain Research Reviews

Schizophrenia research and treatmentPsychedelics and Drug Studies

Cited by 529

5-HT2AReceptor-Mediated Regulation of Brain-Derived Neurotrophic Factor mRNA in the Hippocampus and the Neocortex

Vaidya, V. A., Marek, G. J., Aghajanian, G. K., & Duman, R. S. (1997) · The Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorPsychedelics and Drug Studies

Cited by 479

Lysergic acid diethylamide: Sensitive neuronal units in the midbrain raphe

Aghajanian, G. K., Foote, W. E., & Sheard, M. H. (1968) · Science

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 404

Brain-Derived Neurotrophic Factor Val66Met Allele Impairs Basal and Ketamine-Stimulated Synaptogenesis in Prefrontal Cortex

Liu, R.-J., Lee, F. S., Li, X.-Y., Bambico, F., Duman, R. S., & Aghajanian, G. K. (2012) · Biological Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 403

Serotonin and hallucinogens

Aghajanian, G. (1999) · Neuropsychopharmacology

Psychedelics and Drug StudiesNeurotransmitter Receptor Influence on Behavior

Cited by 371

Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy

Liu, R.-J., & Aghajanian, G. K. (2008) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchStress Responses and Cortisol

Cited by 346

Increased turnover of norepinephrine in the rat cerebral cortex during stress: role of the locus coeruleus

Korf, J., Aghajanian, G. K., & Roth, R. H. (1973) · Neuropharmacology

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 311

REDD1 is essential for stress-induced synaptic loss and depressive behavior

Ota, K. T., Liu, R.-J., Voleti, B., Maldonado-Aviles, J. G., Duric, V., Iwata, M., Dutheil, S., Duman, C., Boikess, S., Lewis, D. A., et al. (2014) · Nature Medicine

Treatment of Major DepressionStress Responses and Cortisol

Cited by 267

Optogenetic stimulation of infralimbic PFC reproduces ketamine’s rapid and sustained antidepressant actions

Fuchikami, M., Thomas, A., Liu, R., Wohleb, E. S., Land, B. B., DiLeone, R. J., Aghajanian, G. K., & Duman, R. S. (2015) · Proceedings of the National Academy of Sciences

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 265

Scopolamine Rapidly Increases Mammalian Target of Rapamycin Complex 1 Signaling, Synaptogenesis, and Antidepressant Behavioral Responses

Voleti, B., Navarria, A., Liu, R.-J., Banasr, M., Li, N., Terwilliger, R., Sanacora, G., Eid, T., Aghajanian, G., & Duman, R. S. (2013) · Biological Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 264

Nicotine Induces Glutamate Release from Thalamocortical Terminals in Prefrontal Cortex

Lambe, E. K., Picciotto, M. R., & Aghajanian, G. K. (2003) · Neuropsychopharmacology

Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology Research

Cited by 261

GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine

Liu, R.-J., Fuchikami, M., Dwyer, J. M., Lepack, A. E., Duman, R. S., & Aghajanian, G. K. (2013) · Neuropsychopharmacology

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 256

Effects of Amphetamine on Single Cell Activity in a Catecholamine Nucleus, the Locus Coeruleus

GRAHAM, A. W., & AGHAJANIAN, G. K. (1971) · Nature

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 165

Serotonin (5-HT) induces IPSPs in pyramidal layer cells of rat piriform cortex: evidence for the involvement of a 5-HT2 -activated interneuron

Sheldon, P. W., & Aghajanian, G. K. (1990) · Brain Research

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 164

Molecular control of locus coeruleus neurotransmission

Nestler, E. J., Alreja, M., & Aghajanian, G. K. (1999) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 155

Hypocretin and Nicotine Excite the Same Thalamocortical Synapses in Prefrontal Cortex: Correlation with Improved Attention in Rat

Lambe, E. K., Olausson, P., Horst, N. K., Taylor, J. R., & Aghajanian, G. K. (2005) · The Journal of Neuroscience

Sleep and Wakefulness ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 135

GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine

Liu, R.-J., Duman, C., Kato, T., Hare, B., Lopresto, D., Bang, E., Burgdorf, J., Moskal, J., Taylor, J., Aghajanian, G., et al. (2017) · Neuropsychopharmacology

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 105

Effect of hallucinogens on spontaneous and sensory-evoked locus coeruleus unit activity in the rat: reversal by selective 5-HT2antagonists

Rasmussen, K., & Aghajanian, G. K. (1986) · Brain Research

Psychedelics and Drug StudiesNeurotransmitter Receptor Influence on Behavior

Cited by 103

Hallucinogen-Induced UP States in the Brain Slice of Rat Prefrontal Cortex: Role of Glutamate Spillover and NR2B-NMDA Receptors

Lambe, E. K., & Aghajanian, G. K. (2006) · Neuropsychopharmacology

Psychedelics and Drug StudiesNeuroscience and Neuropharmacology Research

Cited by 75