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Cited by 173Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionBlood Pressure and Hypertension Studies

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals

Higashi, Y., Sasaki, S., Nakagawa, K., Fukuda, Y., Matsuura, H., Oshima, T., Chayama, K.·2002·American Journal of Hypertension
DOI 10.1016/s0895-7061(01)02317-2
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Abstract

BACKGROUND: A deficiency of tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide (NO) synthase, decreases NO synthesis and increases superoxide production. Supplementation of BH4 has been postulated to improve endothelial function in atherosclerotic patients. The purpose of this study was to determine whether BH4 restores endothelium-dependent vasodilation in patients with essential hypertension. METHODS: We evaluated the effects of BH4 on forearm vascular responses to acetylcholine (ACh), an endothelium-dependent vasodilator, and isosorbide dinitrate (ISDN), an endothelium-independent vasodilator, both in patients with essential hypertension and in age- and sex-matched normal control subjects. Forearm blood flow (FBF) was measured using strain gauge plethysmography. RESULTS: The response of FBF to ACh was less in hypertensive patients (n = 8) than in normal control subjects (n = 8). There was no significant difference in FBF response to ISDN in the two groups. During coinfusion of BH4 (500 mg/min), the FBF response to ACh in hypertensive patients increased significantly (14.8 +/- 4.6 to 25.6 +/- 7.3 mL/min/100 mL tissue, P < .05) to the level of normal control subjects. In the control subjects, also, BH4 augmented the FBF response to ACh (27.8 +/- 8.7 to 36.1 +/- 9.6 mL/min/100 mL tissue, P < .05). The increase in FBF after ISDN was not altered by BH4 in either group (each group, n = 6). CONCLUSION: Supplementation of BH4 augments endothelium-dependent vasodilation in both normotensive and hypertensive individuals.

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  1. 1999, Hypertension, 33, 16
  2. 1998, Circulation, 98, I-735

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Metadata

Authors
Higashi, Y., Sasaki, S., Nakagawa, K., Fukuda, Y., Matsuura, H., Oshima, T., & Chayama, K.
Affiliations
Hiroshima University (JP)
Corresponding author
Higashi, Y.
ORCID
Venue
American Journal of Hypertension
Publisher
Oxford University Press (OUP)
Published
2002-04-01
Volume
15
Issue
4
Pages
326-332
ISSN
  • 0895-7061 (ISSN-L)
  • 1941-7225
DOI
10.1016/s0895-7061(01)02317-2
OpenAlex
W2028671428
Cited by
173
References
31
Citations by year
2025: 5 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 9 · 2014: 9 · 2013: 11 · 2012: 18
FWCI
2.40
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
tetrahydrobiopterin, BH4 supplementation, endothelium-dependent vasodilation, acetylcholine, forearm blood flow, essential hypertension, isosorbide dinitrate, nitric oxide synthase cofactor, endothelial function, forearm circulation
MeSH terms
Acetylcholine, Adult, Biopterins, Drug Synergism, Endothelium, Vascular, Female, Forearm, Humans, Hypertension, Male, Middle Aged, Nitric Oxide, Regional Blood Flow, Nitric Oxide Synthase, Nitric Oxide Synthase Type III

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