Cited by 1,590Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionEicosanoids and Hypertension Pharmacology

Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man

Vallance, Patrick, Collier, Joe, Moncada, Salvador·1989·The Lancet

Abstract

NG monomethyl-L-arginine (L-NMMA), a specific inhibitor of the synthesis of endothelium-derived nitric oxide (NO), was infused into the brachial arteries of healthy volunteers to study the role of NO in the control of forearm blood flow. L-NMMA caused a 50% fall in basal blood flow and attenuated the dilator response to infused acetylcholine but not that to glyceryl trinitrate. These results indicate that the dilator action of endothelium-derived NO contributes to the control of basal and stimulated regional blood flow in man. Impairment of production of NO might account for the abnormalities in vascular reactivity that characterise a wide variety of disease states.

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(89)91013-1

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21 of 21 references verified0 citation errors · 0 not checkable

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  • The endothelial isoform of nitric oxide synthase (eNOS) is responsible for the biosynthesis of NO in endothelial cells, which mediates vascular relaxation.

    “The endothelial isoform of nitric oxide synthase (eNOS) is responsible for the biosynthesis of NO in endothelial cells which mediates vascular relaxation [146].”

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Authors
Vallance, P., Collier, J., & Moncada, S.
Affiliations
  • St George's Hospital (GB)
  • Wellcome Trust (GB)
Venue
The Lancet
Publisher
Elsevier BV
Published
1989-10
Volume
334
Issue
8670
Pages
997-1000
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W2045138089
Cited by
1,590
References
21
Citations by year
2026: 4 · 2025: 3 · 2024: 12 · 2023: 11 · 2022: 19 · 2021: 18 · 2020: 18 · 2019: 16 · 2018: 12 · 2017: 18 · 2016: 16 · 2015: 29 · 2014: 31 · 2013: 35 · 2012: 25
FWCI
39.77
Type
journal article
Language
en
Open access
closed
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords
nitric oxide, endothelium-derived nitric oxide, L-NMMA, peripheral arterial tone, forearm blood flow, brachial artery, acetylcholine, nitroglycerin, vasodilation, vascular reactivity, nitric oxide synthesis inhibition
MeSH terms
Acetylcholine, Adult, Arginine, Brachial Artery, Dose-Response Relationship, Drug, Drug Evaluation, Endothelium, Vascular, Female, Forearm, Nitroglycerin, Humans, Infusions, Intra-Arterial, Male, Muscle Tonus, Nitric Oxide, Regional Blood Flow, Time Factors, Vasodilation, omega-N-Methylarginine

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