The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Localization and function of angiotensin AT1 receptors.
Abstract
The distributions of angiotensin AT1 and AT2 receptors have been mapped by in vitro autoradiography throughout most tissues of many mammals, including humans. In addition to confirming that AT1 receptors occur in sites known to be targets for the physiologic actions of angiotensin, such as the adrenal cortex and medulla, renal glomeruli and proximal tubules, vascular and cardiac muscle and brain circumventricular organs, many new sites of action have been demonstrated. In the kidney, AT1 receptors occur in high density in renal medullary interstitial cells. The function of these cells, which span the interstitial space between the tubules and the vasa rectae, remains to be determined. Renal medullary interstitial cells possess receptors for a number of vasoactive hormones in addition to AT1 receptors and this, in concert with their anatomic location, suggests they may be important for the regulation of fluid reabsorption or renal medullary blood flow. In the heart, the highest densities of AT1 receptors occur in association with the conduction system and vagal ganglia. In the central nervous system, high AT1 receptor densities occur in many regions behind the blood-brain barrier, supporting a role for neurally derived angiotensin as a neuromodulator. The physiologic role of angiotensin in many of these brain sites remains to be determined. The AT2 receptor also has a characteristic distribution in several tissues including the adrenal gland, heart, and brain. The role of this receptor in physiology is being elucidated, but it appears to inhibit proliferation and to participate in development. Thus, receptor-binding studies, localizing the distribution of AT1 and AT2 receptors, provide many insights into novel physiologic roles of angiotensin.
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In the citing paper
“The leading role in such actions belongs to the AT1 receptors.”
From Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease (2021) · cites this paper as Allen et al., 2000
In the citing paper
“Angiotensin II exerts physiologic actions via binding to receptors on cells of different organs (the kidneys, heart, blood vessels, etc.).”
From Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease (2021) · cites this paper as Allen et al., 2000
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Cites
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Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor
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Paracrine regulation of the renal microcirculation
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Cited by
Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology
Forrester, S. J., Booz, G. W., Sigmund, C. D., Coffman, T. M., Kawai, T., Rizzo, V., Scalia, R., & Eguchi, S. (2018) · Physiological Reviews · doi:10.1152/physrev.00038.2017 · Cited by 1,095
Touyz, R. M., & Schiffrin, E. L. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01471-6 · Cited by 934
Angiotensin AT1/AT2 Receptors: Regulation, Signalling and Function
KASCHINA, E., & UNGER, T. (2003) · Blood Pressure · doi:10.1080/08037050310001057 · Cited by 458
Zimmerman, M. C., Lazartigues, E., Sharma, R. V., & Davisson, R. L. (2004) · Circulation Research · doi:10.1161/01.res.0000135483.12297.e4 · Cited by 439
Wagner, C. A., Finberg, K. E., Breton, S., Marshansky, V., Brown, D., & Geibel, J. P. (2004) · Physiological Reviews · doi:10.1152/physrev.00045.2003 · Cited by 443
Metadata
- Authors
- ALLEN, A.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- ALLEN, A
- ORCID
- ALLEN, A
- Venue
- American Journal of Hypertension
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01
- Volume
- 13
- Issue
- 1
- Pages
- S31-S38
- ISSN
- 0895-7061 (ISSN-L)
- OpenAlex
- W2037211353
- Cited by
- 278
- References
- 74
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 10 · 2022: 14 · 2021: 21 · 2020: 12 · 2019: 11 · 2018: 11 · 2017: 11 · 2016: 15 · 2015: 10 · 2014: 3 · 2013: 13 · 2012: 13
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Keywords
- angiotensin II type 1 receptor, angiotensin II type 2 receptor, receptor distribution, cardiac conduction system, vagal ganglia, circumventricular organs, neuromodulation, adrenal cortex, renal blood flow, fluid reabsorption, cell proliferation inhibition, receptor binding
- MeSH terms
- Animals, Humans, Kidney, Myocardium, Receptors, Angiotensin, Renin-Angiotensin System, Receptor, Angiotensin, Type 2, Receptor, Angiotensin, Type 1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
