Cited by 288Renin-Angiotensin System StudiesEicosanoids and Hypertension PharmacologyCardiovascular, Neuropeptides, and Oxidative Stress Research

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Localization and function of angiotensin AT1 receptors.

ALLEN, A·2000·American Journal of Hypertension

DOI 10.1016/s0895-7061(99)00249-6

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Abstract

The distributions of angiotensin AT1 and AT2 receptors have been mapped by in vitro autoradiography throughout most tissues of many mammals, including humans. In addition to confirming that AT1 receptors occur in sites known to be targets for the physiologic actions of angiotensin, such as the adrenal cortex and medulla, renal glomeruli and proximal tubules, vascular and cardiac muscle and brain circumventricular organs, many new sites of action have been demonstrated. In the kidney, AT1 receptors occur in high density in renal medullary interstitial cells. The function of these cells, which span the interstitial space between the tubules and the vasa rectae, remains to be determined. Renal medullary interstitial cells possess receptors for a number of vasoactive hormones in addition to AT1 receptors and this, in concert with their anatomic location, suggests they may be important for the regulation of fluid reabsorption or renal medullary blood flow. In the heart, the highest densities of AT1 receptors occur in association with the conduction system and vagal ganglia. In the central nervous system, high AT1 receptor densities occur in many regions behind the blood-brain barrier, supporting a role for neurally derived angiotensin as a neuromodulator. The physiologic role of angiotensin in many of these brain sites remains to be determined. The AT2 receptor also has a characteristic distribution in several tissues including the adrenal gland, heart, and brain. The role of this receptor in physiology is being elucidated, but it appears to inhibit proliferation and to participate in development. Thus, receptor-binding studies, localizing the distribution of AT1 and AT2 receptors, provide many insights into novel physiologic roles of angiotensin.

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Angiotensin II receptors and angiotensin II receptor antagonists.
Timmermans, P. B., Wong, P. C., Chiu, A. T., Herblin, W. F., Benfield, P., Carini, D. J., Lee, R. J., Wexler, R. R., Saye, J. A., & Smith, R. D. (1993) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00446-6 · Cited by 1,853
Renin-angiotensin system: biochemistry and mechanisms of action.
Peach, M. J. (1977) · Physiological Reviews · doi:10.1152/physrev.1977.57.2.313 · Cited by 1,378
Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor
Murphy, T. J., Alexander, R. W., Griendling, K. K., Runge, M. S., & Bernstein, K. E. (1991) · Nature · doi:10.1038/351233a0 · Cited by 1,252
The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.
Stoll, M., Steckelings, U. M., Paul, M., Bottari, S. P., Metzger, R., & Unger, T. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117710 · Cited by 906
Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor
Ichiki, T., Labosky, P. A., Shiota, C., Okuyama, S., Imagawa, Y., Fogo, A., Niimura, F., Ichikawa, I., Hogan, B. L. M., & lnagami, T. (1995) · Nature · doi:10.1038/377748a0 · Cited by 855
Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor
Sasaki, K., Yamano, Y., Bardhan, S., Iwai, N., Murray, J. J., Hasegawa, M., Matsudat, Y., & lnagami, T. (1991) · Nature · doi:10.1038/351230a0 · Cited by 811
Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.
Mukoyama, M., Nakajima, M., Horiuchi, M., Sasamura, H., Pratt, R. E., & Dzau, V. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74498-6 · Cited by 768
Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice
Hein, L., Barsh, G. S., Pratt, R. E., Dzau, V. J., & Kobilka, B. K. (1995) · Nature · doi:10.1038/377744a0 · Cited by 742
Paracrine regulation of the renal microcirculation
Navar, L. G., Inscho, E. W., Majid, S. A., Imig, J. D., Harrison-Bernard, L. M., & Mitchell, K. D. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.2.425 · Cited by 741
Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.
Kambayashi, Y., Bardhan, S., Takahashi, K., Tsuzuki, S., Inui, H., Hamakubo, T., & Inagami, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74499-8 · Cited by 714

Show all 74 references

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology
Forrester, S. J., Booz, G. W., Sigmund, C. D., Coffman, T. M., Kawai, T., Rizzo, V., Scalia, R., & Eguchi, S. (2018) · Physiological Reviews · doi:10.1152/physrev.00038.2017 · Cited by 1,095
Signal Transduction Mechanisms Mediating the Physiological and Pathophysiological Actions of Angiotensin II in Vascular Smooth Muscle Cells
Touyz, R. M., & Schiffrin, E. L. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01471-6 · Cited by 934
Angiotensin AT1/AT2 Receptors: Regulation, Signalling and Function
KASCHINA, E., & UNGER, T. (2003) · Blood Pressure · doi:10.1080/08037050310001057 · Cited by 458
Hypertension Caused by Angiotensin II Infusion Involves Increased Superoxide Production in the Central Nervous System
Zimmerman, M. C., Lazartigues, E., Sharma, R. V., & Davisson, R. L. (2004) · Circulation Research · doi:10.1161/01.res.0000135483.12297.e4 · Cited by 439
Renal Vacuolar H+-ATPase
Wagner, C. A., Finberg, K. E., Breton, S., Marshansky, V., Brown, D., & Geibel, J. P. (2004) · Physiological Reviews · doi:10.1152/physrev.00045.2003 · Cited by 443
Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system
Doobay, M. F., Talman, L. S., Obr, T. D., Tian, X., Davisson, R. L., & Lazartigues, E. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00292.2006 · Cited by 406
Tissue Renin-Angiotensin-Aldosterone Systems: Targets for Pharmacological Therapy
Bader, M. (2010) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105610 · Cited by 345
The renin–angiotensin system in cardiovascular autonomic control: recent developments and clinical implications
Miller, A. J., & Arnold, A. C. (2019) · Clinical Autonomic Research · doi:10.1007/s10286-018-0572-5 · Cited by 288
Involvement of Tumor Necrosis Factor-α in Angiotensin II–Mediated Effects on Salt Appetite, Hypertension, and Cardiac Hypertrophy
Sriramula, S., Haque, M., Majid, D. S. A., & Francis, J. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.102152 · Cited by 278
Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide
Berry, C., Touyz, R., Dominiczak, A. F., Webb, R. C., & Johns, D. G. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.6.h2337 · Cited by 259
Recent advances in angiotensin II signaling
Touyz, R. M., & Berry, C. (2002) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2002000900001 · Cited by 243
HDAC Inhibition Attenuates Inflammatory, Hypertrophic, and Hypertensive Responses in Spontaneously Hypertensive Rats
Cardinale, J. P., Sriramula, S., Pariaut, R., Guggilam, A., Mariappan, N., Elks, C. M., & Francis, J. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.154567 · Cited by 217
Possible involvement of the adipose tissue renin‐angiotensin system in the pathophysiology of obesity and obesity‐related disorders
Goossens, G. H., Blaak, E. E., & van Baak, M. A. (2003) · Obesity Reviews · doi:10.1046/j.1467-789x.2003.00091.x · Cited by 188
The angiotensin II type 2 receptor in cardiovascular disease
Lemarié, C. A., & Schiffrin, E. L. (2009) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320309347785 · Cited by 188
ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension
Sriramula, S., Cardinale, J. P., Lazartigues, E. D., & Francis, J. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr242 · Cited by 185
Angiotensin-converting Enzyme 2 (ACE2), But Not ACE, Is Preferentially Localized to the Apical Surface of Polarized Kidney Cells
Warner, F. J., Lew, R. A., Smith, A. I., Lambert, D., Hooper, N. M., & Turner, A. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508914200 · Cited by 182
Maternal low-protein diet in rat pregnancy programs blood pressure through sex-specific mechanisms
McMullen, S., & Langley‐Evans, S. C. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00435.2004 · Cited by 160
Salt craving: The psychobiology of pathogenic sodium intake
Morris, M. J., Na, E. S., & Johnson, A. K. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.04.008 · Cited by 141
The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system
Ferder, M., Inserra, F., Manucha, W. A., & Ferder, L. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00403.2011 · Cited by 139
The Burden of Uncontrolled Hypertension: Morbidity and Mortality Associated With Disease Progression
Cushman, W. C. (2003) · Journal of Clinical Hypertension · doi:10.1111/j.1524-6175.2003.02464.x · Cited by 117
Redox signaling in central neural regulation of cardiovascular function
Zimmerman, M. C., & Davisson, R. L. (2003) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2003.11.009 · Cited by 116
Prenatal programming of angiotensin II type 2 receptor expression in the rat
McMullen, S., Gardner, D. S., & Langley‐Evans, S. C. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20031029 · Cited by 116
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Lopez-Ilasaca, M. A., Liu, X., Tamura, K., & Dzau, V. J. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-06-0383 · Cited by 114
Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors
Bedoya-Reina, O. C., Li, W., Arceo, M., Plescher, M., Bullova, P., Pui, H., Kaucká, M., Kharchenko, P. V., Martinsson, T., Holmberg, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24870-7 · Cited by 105
Classic and Nonclassic Renin-Angiotensin Systems in the Critically Ill
Bitker, L., & Burrell, L. M. (2019) · Critical Care Clinics · doi:10.1016/j.ccc.2018.11.002 · Cited by 103
Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ
Coble, J., Grobe, J. L., Johnson, A. K., & Sigmund, C. D. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00486.2014 · Cited by 103
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Coulson, R. S., Liew, S. H., Connelly, A. A., Yee, N. S., Deb, S., Kumar, B., Vargas, A. C., O'Toole, S. A., Parslow, A. C., Poh, A. R., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15553 · Cited by 103
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Marc, Y., & Llorens‐Cortés, C. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.06.006 · Cited by 100
Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats
Wright, J. W., Tamura-Myers, E., Wilson, W. L., Roques, B. P., Llorens‐Cortés, C., Speth, R. C., & Harding, J. W. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00326.2002 · Cited by 95
Involvement of insulin-regulated aminopeptidase in the effects of the renin–angiotensin fragment angiotensin IV: a review
Stragier, B., Bundel, D. D., Sarre, S., Smolders, I. J., Vauquelin, G., Dupont, A. G., Michotte, Y. M., & Vanderheyden, P. (2007) · Heart Failure Reviews · doi:10.1007/s10741-007-9062-x · Cited by 94
G-Protein Coupled Receptors and Tau-different Roles in Alzheimer’s Disease
Chidambaram, H., & Chinnathambi, S. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.04.019 · Cited by 87
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Chandra, S., Narang, R., Sreenivas, V., Bhatia, J., Saluja, D., & Srivastava, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101502 · Cited by 87
Renin-Angiotensin System: Updated Understanding and Role in Physiological and Pathophysiological States
Kanugula, A. K., Kaur, J., Batra, J., Ankireddypalli, A. R., & Velagapudi, R. (2023) · Cureus · doi:10.7759/cureus.40725 · Cited by 84
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Ferreira, A. J., Murça, T. M., Fraga-Silva, R. A., Castro, C. H., Raizada, M. K., & Santos, R. A. S. (2012) · International Journal of Hypertension · doi:10.1155/2012/147825 · Cited by 83
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Haulica, I. D., Bild, W., & Șerban, D. N. (2005) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.3317/jraas.2005.018 · Cited by 82
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Morris, K. L., & Zemel, M. B. (2005) · Obesity Research · doi:10.1038/oby.2005.75 · Cited by 81
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Reja, V., Goodchild, A. K., Phillips, J. K., & Pilowsky, P. M. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04420.x · Cited by 78
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Regan, J. A., Mauro, A. G., Carbone, S., Marchetti, C., Gill, R., Mezzaroma, E., Raleigh, J. V., Salloum, F. N., Tassell, B. W. V., Abbate, A., et al. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00282.2015 · Cited by 78
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Rothenberger, F., Velić, A., Stehberger, P. A., Kovacikova, J., & Wagner, C. A. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006070753 · Cited by 78
Vascular biology of angiotensin and the impact of physical activity
Rush, J. W. E., & Aultman, C. D. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-147 · Cited by 78
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Cellular targets for angiotensin II fragments: pharmacological and molecular evidence
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Tan, J., Wang, H., & Leenen, F. H. H. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00858.2003 · Cited by 65
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Adaptive constrained constructive optimisation for complex vascularisation processes
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Rasini, E., Cosentino, M., Marino, F., Legnaro, M., Ferrari, M., Guasti, L., Venco, A., & Lecchini, S. (2006) · Regulatory Peptides · doi:10.1016/j.regpep.2006.01.007 · Cited by 57
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Wang, X., Phillips, M. I., & Mehta, J. L. (2011) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-011-6331-7 · Cited by 47
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Knight, W. D., Saxena, A., Shell, B., Nedungadi, T. P., Mifflin, S. W., & Cunningham, J. T. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00541.2012 · Cited by 47
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Authors: ALLEN, A.
Affiliations: The University of Melbourne (AU)
Corresponding author: ALLEN, A
ORCID: ALLEN, A
Venue: American Journal of Hypertension
Publisher: Oxford University Press (OUP)
Published: 2000-01
Volume: 13
Issue: 1
Pages: S31-S38
ISSN: 0895-7061 (ISSN-L)
DOI: 10.1016/s0895-7061(99)00249-6
OpenAlex: W2037211353
Cited by: 278
References: 74
Citations by year: 2026: 2 · 2025: 2 · 2024: 3 · 2023: 10 · 2022: 14 · 2021: 21 · 2020: 12 · 2019: 11 · 2018: 11 · 2017: 11 · 2016: 15 · 2015: 10 · 2014: 3 · 2013: 13 · 2012: 13
FWCI: 2.19
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Hypertension (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Keywords: angiotensin II type 1 receptor, angiotensin II type 2 receptor, receptor distribution, cardiac conduction system, vagal ganglia, circumventricular organs, neuromodulation, adrenal cortex, renal blood flow, fluid reabsorption, cell proliferation inhibition, receptor binding
MeSH terms: Animals, Humans, Kidney, Myocardium, Receptors, Angiotensin, Renin-Angiotensin System, Receptor, Angiotensin, Type 2, Receptor, Angiotensin, Type 1

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Localization and function of angiotensin AT1 receptors.

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