Filopodia, spines, and the generation of synaptic diversity
Open accessAbstract
Central nervous systems are bewilderingly complex, containing enormous numbers of cells that are connected by an even greater number of synapses. Moreover, the brains of no two vertebrate conspecifics are exactly alike, differing in the numbers and positions of their cells and the patterns of their synaptic connections. Despite this heterogeneity at the cellular and subcellular levels, brains are not disorganized masses of neural tissue, but are reproducibly organized into highly stereotyped functional systems that have been preserved throughout evolutionary history. The questions confronting the neurobiologist include two important and related issues: how nervous systems are constructed during development, generating a conserved architecture from a heterogeneous substrate, and how changes in mature neural circuits are related to the remodeling events that characterize neural development.
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Spine motility permits the sampling of large numbers of potential presynaptic partners before connections are stabilized via activity-dependent mechanisms.
“This would be advantageous, because spine motility permits the sampling of large numbers of potential presynaptic partners before connections are stabilized via activity-dependent mechanisms (Jontes and Smith, 2000; Portera-Cailliau et al., 2003).”
From The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning (2017) · cites this paper as Jontes and Smith, 2000
In the discussion of divergent roles for filopodia and spines (page unavailable), the paper assigns broad sampling of potential inputs to motile filopodia. It says new spines instead appear preferentially associated with previously active presynaptic boutons, strengthening an existing connection—not sampling many potential partners. (LLM, conf=0.87)
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- Authors
- Jontes, J. D., & Smith, S. J.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Smith, Stephen J
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2000-07
- Volume
- 27
- Issue
- 1
- Pages
- 11-14
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2067308061
- Cited by
- 184
- References
- 3
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 7 · 2013: 4 · 2012: 2
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- filopodia, synaptic diversity, synaptic plasticity, neural development, neural circuit remodeling, dendritic morphology, brain heterogeneity, neural circuit organization
- MeSH terms
- Animals, Dendrites, Humans, Synapses
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