The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Mechanisms for Activation and Antagonism of an AMPA-Sensitive Glutamate Receptor
Open accessAbstract
Crystal structures of the GluR2 ligand binding core (S1S2) have been determined in the apo state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full agonists AMPA and glutamate. The domains of the S1S2 ligand binding core are expanded in the apo state and contract upon ligand binding with the extent of domain separation decreasing in the order of apo > DNQX > kainate > glutamate approximately equal to AMPA. These results suggest that agonist-induced domain closure gates the transmembrane channel and the extent of receptor activation depends upon the degree of domain closure. AMPA and glutamate also promote a 180 degrees flip of a trans peptide bond in the ligand binding site. The crystal packing of the ligand binding cores suggests modes for subunit-subunit contact in the intact receptor and mechanisms by which allosteric effectors modulate receptor activity.
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Cited by
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568
Ionotropic and metabotropic glutamate receptor structure and pharmacology
Kew, J. N. C., & Kemp, J. A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2200-z · Cited by 788
Subunit arrangement and function in NMDA receptors
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Self-citationStructure, Function, and Pharmacology of Glutamate Receptor Ion Channels
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Allosteric control of an ionotropic glutamate receptor with an optical switch
Volgraf, M., Gorostiza, P., Numano, R., Kramer, R. H., Isacoff, E. Y., & Trauner, D. (2006) · Nature Chemical Biology · doi:10.1038/nchembio756 · Cited by 573
Metadata
- Authors
- Armstrong, N., & Gouaux, E.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2000-10
- Volume
- 28
- Issue
- 1
- Pages
- 165-181
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1922786159
- Cited by
- 872
- References
- 83
- FWCI
- 15.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Armstrong, N., & Gouaux, E. (2000). Mechanisms for Activation and Antagonism of an AMPA-Sensitive Glutamate Receptor. Neuron. https://doi.org/10.1016/s0896-6273(00)00094-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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