The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.
Activation of a TRPC3-Dependent Cation Current through the Neurotrophin BDNF
Open accessAbstract
Nonvoltage-gated cation currents, which are activated following stimulation of phospholipase C (PLC), appear to be major modes for Ca2+ and Na+ entry in mammalian cells. The TRPC channels may mediate some of these conductances since their expression in vitro leads to PLC-dependent cation influx. We found that the TRPC3 protein was highly enriched in neurons of the central nervous system (CNS). The temporal and spatial distribution of TRPC3 paralleled that of the neurotrophin receptor TrkB. Activation of TrkB by brain-derived nerve growth factor (BDNF) led to production of a PLC-dependent, nonselective cation conductance in pontine neurons. Evidence is provided that TRPC3 contributes to this current in vivo. Thus, activation of TrkB and PLC leads to a TRPC3-dependent cation influx in CNS neurons.
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“Bath application of a low concentration (20 ng/ ml) of BDNF did not by itself induce spine-head enlargement (n = 30) (Fig. 4A) or inward currents (0.5 ± 1.2 pA, n = 5) (Fig. 4B) (19, 20).”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [20]
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“Bath application of a low concentration (20 ng/ ml) of BDNF did not by itself induce spine-head enlargement (n = 30) (Fig. 4A) or inward currents (0.5 ± 1.2 pA, n = 5) (Fig. 4B) (19, 20).”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [20]
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Metadata
- Authors
- Li, H.-S., Xu, X.-Z. S., & Montell, C.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Montell, Craig
- ORCID
- Montell, Craig
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1999-09
- Volume
- 24
- Issue
- 1
- Pages
- 261-273
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1968399538
- Cited by
- 345
- References
- 55
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 9 · 2023: 9 · 2022: 11 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 10 · 2017: 11 · 2016: 10 · 2015: 11 · 2014: 11 · 2013: 12 · 2012: 18
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (EY10852)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- TRPC3, TRPC channels, brain-derived neurotrophic factor, TrkB receptor, neurotrophin signaling, phospholipase C, calcium influx, sodium influx, pontine neurons, central nervous system neurons, cation conductance
- MeSH terms
- Animals, Cations, Cell Line, Cerebral Cortex, Electric Conductivity, Humans, Ion Channels, Neurons, Type C Phospholipases, Pons, Tissue Distribution, Transfection, Brain-Derived Neurotrophic Factor, Receptor, trkB, TRPC Cation Channels, Rats
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