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Cited by 390Ion channel regulation and functionCardiac electrophysiology and arrhythmiasIon Transport and Channel Regulation

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Altered Subthreshold Sodium Currents and Disrupted Firing Patterns in Purkinje Neurons of Scn8a Mutant Mice

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Raman, Indira M, Sprunger, Leslie K, Meisler, Miriam H, Bean, Bruce P·1997·Neuron
DOI 10.1016/s0896-6273(00)80969-1
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Abstract

Sodium currents and action potentials were characterized in Purkinje neurons from ataxic mice lacking expression of the sodium channel Scn8a. Peak transient sodium current was approximately 60% of that in normal mice, but subthreshold sodium current was affected much more. Steady-state current elicited by voltage ramps was reduced to approximately 30%, and resurgent sodium current, an unusual transient current elicited on repolarization following strong depolarizations, was reduced to 8%-18%. In jolting mice, with a missense mutation in Scn8a, steady-state and resurgent current were also reduced, with altered voltage dependence and kinetics. Both spontaneous firing and evoked bursts of spikes were diminished in cells from null and jolting mice. Evidently Scn8a channels carry most subthreshold sodium current and are crucial for repetitive firing.

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Crossref · 10.1016/s0896-6273(00)80969-1

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45 of 45 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 1

  1. Dickie, 1965, Jolting, Mouse News Lett, 32, 44

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Metadata

Authors
Raman, I. M., Sprunger, L. K., Meisler, M. H., & Bean, B. P.
Affiliations
  • Harvard University (US)
  • University of Michigan (US)
Corresponding author
Raman, Indira M
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
1997-10
Volume
19
Issue
4
Pages
881-891
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/s0896-6273(00)80969-1
OpenAlex
W2090477486
Cited by
390
References
45
Citations by year
2026: 4 · 2025: 7 · 2024: 9 · 2023: 14 · 2022: 14 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 11 · 2017: 16 · 2016: 14 · 2015: 11 · 2014: 14 · 2013: 10 · 2012: 21
FWCI
4.39
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (R01NS036855, F32-NS10396, R01-NS34059, R01NS36855, F32NS010396)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
SCN8A, sodium channels, Purkinje cells, resurgent sodium current, missense mutations, ataxia, repetitive firing, action potential, cerebellum
MeSH terms
Animals, Calcium, Crosses, Genetic, Evoked Potentials, Genotype, Heterozygote, Kinetics, Membrane Potentials, Mice, Inbred C3H, Mice, Inbred C57BL, Nerve Tissue Proteins, Purkinje Cells, Time Factors, Sodium Channels, Polymerase Chain Reaction, Mice, Knockout, Patch-Clamp Techniques, Mice, NAV1.6 Voltage-Gated Sodium Channel, In Vitro Techniques

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