The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Linear Summation of Excitatory Inputs by CA1 Pyramidal Neurons
Open accessAbstract
A fundamental problem in neurobiology is understanding the arithmetic that dendrites use to integrate inputs. The impact of dendritic morphology and active conductances on input summation is still unknown. To study this, we use glutamate iontophoresis and synaptic stimulation to position pairs of excitatory inputs throughout the apical, oblique, and basal dendrites of CA1 pyramidal neurons in rat hippocampal slices. Under a variety of stimulation regimes, we find a linear summation of most input combinations that is implemented by a surprising balance of boosting and shunting mechanisms. Active conductances in dendrites paradoxically serve to make summation linear. This "active linearity" can reconcile predictions from cable theory with the observed linear summation in vivo and suggests that a simple arithmetic is used by apparently complex dendritic trees.
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Neural networks and physical systems with emergent collective computational abilities.
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Maturation of a Central Glutamatergic Synapse
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Cited by
Pyramidal neurons: dendritic structure and synaptic integration
Spruston, N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2286 · Cited by 1,688
The high-conductance state of neocortical neurons in vivo
Destexhe, A., Rudolph, M., & Paré, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1198 · Cited by 1,073
Spike Timing-Dependent Plasticity of Neural Circuits
Dan, Y., & Poo, M.-M. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.007 · Cited by 1,040
Computational subunits in thin dendrites of pyramidal cells
Polsky, A., Mel, B. W., & Schiller, J. (2004) · Nature Neuroscience · doi:10.1038/nn1253 · Cited by 817
Dendritic integration of excitatory synaptic input
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Metadata
- Authors
- Cash, S., & Yuste, R.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1999-02
- Volume
- 22
- Issue
- 2
- Pages
- 383-394
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1991481439
- Cited by
- 305
- References
- 6
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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