Dendritic integration of excitatory synaptic input
Abstract
A fundamental function of nerve cells is the transformation of incoming synaptic information into specific patterns of action potential output. An important component of this transformation is synaptic integration--the combination of voltage deflections produced by a myriad of synaptic inputs into a singular change in membrane potential. There are three basic elements involved in integration: the amplitude of the unitary postsynaptic potential; the manner in which non-simultaneous unitary events add in time (temporal summation), and the addition of unitary events occurring simultaneously in separate regions of the dendritic arbor (spatial summation). This review discusses how passive and active dendritic properties, and the functional characteristics of the synapse, shape these three elements of synaptic integration.
Integrity signals
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The release of norepinephrine or acetylcholine can modulate the state of cortical activity through cell type and subcellular specific effects.
“The release of either of these neurotransmitters can potentially modulate the state of cortical activity through cell type, and even subcellular, specific effects.”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Magee, 2000
Effects consistent with a role in arousal of pyramidal cell networks include depolarization of cortical neurons through reduction of membrane K+ currents, modulation of the h-current, and control of synaptic transmission.
“Effects that are consistent with a role in arousal of pyramidal cell networks include depolarization of cortical neurons through the reduction of a variety of membrane K+ currents (McCormick, 1992), modulation of the h-current (Wang et al., 2007), which controls neuronal and dendritic excitability (Magee, 2000), and control of synaptic transmission, through the modulation of presynaptic terminals”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Magee, 2000
Several EPSPs have to be integrated by temporal and spatial summation to generate action potentials in a postsynaptic target cell.
“Thus, several EPSPs have to be integrated by temporal and spatial summation to generate action potentials (APs) in a postsynaptic target cell 31 .”
From Developmental emergence of sparse and structured synaptic connectivity in the hippocampal CA3 memory circuit (2026) · cites this paper as [31]
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- Authors
- Magee, J. C.
- Affiliations
- Louisiana State University (US)
- Corresponding author
- Magee, Jeffrey C.
- ORCID
- Magee, Jeffrey C.
- Venue
- Nature reviews. Neuroscience
- Published
- 2000-12
- Volume
- 1
- Issue
- 3
- Pages
- 181-190
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W1559348600
- Cited by
- 737
- References
- 60
- Citations by year
- 2026: 28 · 2025: 32 · 2024: 37 · 2023: 25 · 2022: 30 · 2021: 36 · 2020: 32 · 2019: 59 · 2018: 32 · 2017: 20 · 2016: 39 · 2015: 50 · 2014: 33 · 2013: 42 · 2012: 27
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- dendritic integration, excitatory synaptic input, temporal summation, spatial summation, membrane potential
- MeSH terms
- Action Potentials, Animals, Dendrites, Humans, Models, Neurological, Synaptic Transmission, Synapses, Excitatory Postsynaptic Potentials, Cell Size
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