The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
A Therapeutic Vaccine Approach to Stimulate Axon Regeneration in the Adult Mammalian Spinal Cord
Open accessAbstract
Axon growth inhibitors associated with myelin play an important role in the failure of axon regeneration in the adult mammalian central nervous system (CNS). Several inhibitors are present in the mature CNS. We now present a novel therapeutic vaccine approach in which the animals' own immune system is stimulated to produce polyclonal antibodies that block myelin-associated inhibitors without producing any detrimental cellular inflammatory responses. Adult mice immunized in this manner showed extensive regeneration of large numbers of axons of the corticospinal tracts after dorsal hemisection of the spinal cord. The anatomical regeneration led to recovery of certain hind limb motor functions. Furthermore, antisera from immunized mice were able to block myelin-derived inhibitors and promote neurite growth on myelin in vitro.
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Cites
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Self-citationA novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration
Mukhopadhyay, G., Doherty, P., Walsh, F. S., Crocker, P. R., & Filbin, M. T. (1994) · Neuron · doi:10.1016/0896-6273(94)90042-6 · Cited by 1,061
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Fluoro-gold: a new fluorescent retrograde axonal tracer with numerous unique properties
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Regeneration of adult axons in white matter tracts of the central nervous system
Davies, S. J. A., Fitch, M. T., Memberg, S. P., Hall, A. K., Raisman, G., & Silver, J. (1997) · Nature · doi:10.1038/37776 · Cited by 737
Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors
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Cited by
Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration
Fournier, A. E., GrandPre, T., & Strittmatter, S. M. (2001) · Nature · doi:10.1038/35053072 · Cited by 1,080
Donnelly, D. J., & Popovich, P. G. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.06.009 · Cited by 995
Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS
Filbin, M. T. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1195 · Cited by 871
Regenerating the damaged central nervous system
Horner, P. J., & Gage, F. H. (2000) · Nature · doi:10.1038/35039559 · Cited by 831
Kroner, A., Greenhalgh, A. D., Zarruk, J. G., Passos dos Santos, R., Gaestel, M., & David, S. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.027 · Cited by 655
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Metadata
- Authors
- Huang, D. W., McKerracher, L., Braun, P. E., & David, S.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 24
- Issue
- 3
- Pages
- 639-647
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2075892765
- Cited by
- 287
- References
- 32
- FWCI
- 9.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A Therapeutic Vaccine Approach to Stimulate Axon Regeneration in the Adult Mammalian Spinal Cord. https://app.cochat.ai/papers/10.1016/s0896-6273(00)81118-6
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- Huang, D. W., McKerracher, L., Braun, P. E., & David, S. (1999). A Therapeutic Vaccine Approach to Stimulate Axon Regeneration in the Adult Mammalian Spinal Cord. Neuron. https://doi.org/10.1016/s0896-6273(00)81118-6
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
