Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury
Open accessAbstract
Trauma to the central nervous system (CNS) triggers intraparenchymal inflammation and activation of systemic immunity with the capacity to exacerbate neuropathology and stimulate mechanisms of tissue repair. Despite our incomplete understanding of the mechanisms that control these divergent functions, immune-based therapies are becoming a therapeutic focus. This review will address the complexities and controversies of post-traumatic neuroinflammation, particularly in spinal cord. In addition, current therapies designed to target neuroinflammatory cascades will be discussed.
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Immediately after injury the spinal cord undergoes massive cellular and molecular changes, including increased cell death, infiltration of inflammation cells, axon degeneration, and OL and myelin loss.
“Immediately after injury the spinal cord undergoes massive cellular and molecular changes, including increased cell death [64, 65], infiltration of inflammation cells in the lesion [2–6], axon degeneration [7–10], and OL and myelin loss [13–16, 66, 67].”
From Delayed short-term tamoxifen treatment does not promote remyelination or neuron sparing after spinal cord injury (2020) · cites this paper as [3]
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- Authors
- Donnelly, D. J., & Popovich, P. G.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Popovich, Phillip G.
- ORCID
- Popovich, Phillip G.
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2008-02
- Volume
- 209
- Issue
- 2
- Pages
- 378-388
- ISSN
- 0014-4886 (ISSN-L)
- PMC
- PMC2692462
- OpenAlex
- W2023053568
- Cited by
- 995
- References
- 7
- Citations by year
- 2026: 33 · 2025: 45 · 2024: 49 · 2023: 48 · 2022: 68 · 2021: 80 · 2020: 46 · 2019: 63 · 2018: 70 · 2017: 58 · 2016: 58 · 2015: 59 · 2014: 66 · 2013: 55 · 2012: 48
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke
- National Institutes of Health (746703)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- spinal cord injury, neuroinflammation, neuroprotection, axon regeneration, functional recovery, central nervous system injury, systemic immunity, immunotherapy, tissue repair
- MeSH terms
- Animals, Axons, Humans, Inflammation, Regeneration, Spinal Cord Injuries, Recovery of Function
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