The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Calcineurin-Mediated LTD of GABAergic Inhibition Underlies the Increased Excitability of CA1 Neurons Associated with LTP
Open accessAbstract
Coincident pre- and postsynaptic activity generates long-term potentiation (LTP), a possible cellular model of learning and memory. LTP has two components: (1) an increase in the excitatory postsynaptic potential (EPSP), and (2) an increase in the ability of the EPSP to generate a spike (E-S coupling of LTP). We have used pharmacological and genetic approaches to address the molecular nature of E-S coupling in CA1 pyramidal neurons. Blockade of the Ca2+-sensitive phosphatase, calcineurin, prevents induction of E-S coupling without interfering with LTP of the EPSP. Calcineurin produces its effect on E-S coupling by inducing a long-lasting depression (LTD) of the GABA(A)-mediated inhibitory postsynaptic potentials (IPSPs). This LTD of the IPSP was prevented by blockade of NMDA receptors. Thus, the tetanus that elicits NMDA-dependent LTP mediates a coordinately regulated double function. It produces LTP of the EPSP and, concomitantly, LTD of the IPSP that leads to enhancement of E-S coupling.
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Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression
Mulkey, R. M., Endo, S., Shenolikar, S., & Malenka, R. C. (1994) · Nature · doi:10.1038/369486a0 · Cited by 1,083
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Metadata
- Authors
- Lu, Y. M., Mansuy, I. M., Kandel, E. R., & Roder, J.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2000-04
- Volume
- 26
- Issue
- 1
- Pages
- 197-205
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2056722870
- Cited by
- 280
- References
- 2
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lu, Y. M., Mansuy, I. M., Kandel, E. R., & Roder, J. (2000). Calcineurin-Mediated LTD of GABAergic Inhibition Underlies the Increased Excitability of CA1 Neurons Associated with LTP. Neuron. https://doi.org/10.1016/s0896-6273(00)81150-2
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