Spike Timing-Dependent Plasticity: From Synapse to Perception
Abstract
Information in the nervous system may be carried by both the rate and timing of neuronal spikes. Recent findings of spike timing-dependent plasticity (STDP) have fueled the interest in the potential roles of spike timing in processing and storage of information in neural circuits. Induction of long-term potentiation (LTP) and long-term depression (LTD) in a variety of in vitro and in vivo systems has been shown to depend on the temporal order of pre- and postsynaptic spiking. Spike timing-dependent modification of neuronal excitability and dendritic integration was also observed. Such STDP at the synaptic and cellular level is likely to play important roles in activity-induced functional changes in neuronal receptive fields and human perception.
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As the direction of synaptic plasticity depends on the timing between presynaptic and postsynaptic spikes, this phenomenon is named spike-timing-dependent plasticity.
“As the direction of synaptic plasticity depends on the timing between the presynaptic and postsynaptic spikes, this phenomenon has been named spike-timing-dependent plasticity (Dan and Poo 2006;Caporale and Dan 2008).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Dan and Poo 2006
This more robust form of LTP plays an important role in the development and learning of neuronal networks.
“that plays an important role in the development and learning of neuronal networks (6)”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [6]
If synaptic stimulation is closely followed in time by postsynaptic spikes (a spike-timing protocol), a more robust form of LTP is induced.
“if synaptic stimulation is closely followed in time by postsynaptic spikes (a spike-timing protocol), a more robust form of LTP is induced”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [6]
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- Authors
- Dan, Y., & Poo, M.-M.
- Affiliations
- University of California, Berkeley (US)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2006-07
- Volume
- 86
- Issue
- 3
- Pages
- 1033-1048
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2065158671
- Cited by
- 675
- References
- 7
- Citations by year
- 2026: 17 · 2025: 31 · 2024: 18 · 2023: 20 · 2022: 31 · 2021: 38 · 2020: 28 · 2019: 26 · 2018: 36 · 2017: 39 · 2016: 35 · 2015: 29 · 2014: 30 · 2013: 49 · 2012: 45
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- spike-timing-dependent plasticity, long-term potentiation, long-term depression, synaptic plasticity, neuronal excitability, dendritic integration, receptive fields, perception, neural information processing
- MeSH terms
- Action Potentials, Animals, Brain, Humans, Neuronal Plasticity, Perception, Synapses
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