The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Negative Regulation and Gain Control of Sensory Neurons by the C. elegans Calcineurin TAX-6
Open accessAbstract
Animals sense and adapt to variable environments by regulating appropriate sensory signal transduction pathways. Here, we show that calcineurin plays a key role in regulating the gain of sensory neuron responsiveness across multiple modalities. C. elegans animals bearing a loss-of-function mutation in TAX-6, a calcineurin A subunit, exhibit pleiotropic abnormalities, including many aberrant sensory behaviors. The tax-6 mutant defect in thermosensation is consistent with hyperactivation of the AFD thermosensory neurons. Conversely, constitutive activation of TAX-6 causes a behavioral phenotype consistent with inactivation of AFD neurons. In olfactory neurons, the impaired olfactory response of tax-6 mutants to an AWC-sensed odorant is caused by hyperadaptation, which is suppressible by a mutation causing defective olfactory adaptation. Taken together, our results suggest that stimulus-evoked calcium entry activates calcineurin, which in turn negatively regulates multiple aspects of sensory signaling.
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“Yet, C. elegans CFAP-20 participates in several sensory and physiological processes that depend on various types of non-motile cilia: ability to sense and learn to avoid salt in the absence of food (gustatory plasticity); lifespan control; locomotion (roaming); and, body size determination40,42,47–51.”
From The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision (2022) · cites this paper as [51]
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Metadata
- Authors
- Kuhara, A., Inada, H., Katsura, I., & Mori, I.
- Affiliations
- Nagoya University (JP)
- National Institute of Genetics (JP)
- Corresponding author
- Mori, Ikue
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 33
- Issue
- 5
- Pages
- 751-763
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2019816797
- Cited by
- 153
- References
- 57
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 10 · 2019: 4 · 2018: 2 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 9 · 2012: 8
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerio de Economía y Competitividad
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- calcineurin, sensory neurons, gain control, negative regulation, thermosensation, AFD neurons, olfactory adaptation, olfactory sensory neurons, AWC neurons, sensory transduction, calcium influx, Caenorhabditis elegans
- MeSH terms
- Pentanols, Amino Acid Sequence, Animals, Humans, Ion Channels, Locomotion, Models, Biological, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Afferent, Osmolar Concentration, Phenotype, Recombinant Fusion Proteins, Smell, Thermosensing, Signal Transduction, Sequence Alignment, Caenorhabditis elegans, Calcineurin, Protein Subunits, Caenorhabditis elegans Proteins, Animals, Genetically Modified, Transient Receptor Potential Channels, TRPV Cation Channels
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